Ubiquitous Overexpression of Chromatin Remodeling Factor SRG3 Exacerbates Atopic Dermatitis in NC/Nga Mice by Enhancing Th2 Immune Responses

• Published in: International journal of molecular sciences Vol. 22; no. 4; p. 1553
• Main Authors: Lee, Sung Won, Park, Hyun Jung, Jeon, Jungmin, Park, Yun Hoo, Kim, Tae-Cheol, Jeon, Sung Ho, Seong, Rho Hyun, Van Kaer, Luc, Hong, Seokmann
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 04.02.2021; MDPI
• Subjects: Actin; Actins - metabolism; Animals; Atopic dermatitis; Biopsy; Chromatin Assembly and Disassembly; Chromatin remodeling; Cytokines; Dendritic cells; Dendritic Cells - immunology; Dendritic Cells - metabolism; Dermatitis; Dermatitis, Atopic - diagnosis; Dermatitis, Atopic - etiology; Dermatitis, Atopic - metabolism; Disease; Disease Models, Animal; Disease Susceptibility; Eczema; Experimental allergic encephalomyelitis; Gene Expression; Genotype & phenotype; Helper cells; Immune response; Immunity, Cellular; Immunoglobulin E; Inflammation; Interleukin 4; Leukocytes (basophilic); Lymphocytes; Lymphocytes T; Macrophages; Macrophages - immunology; Macrophages - metabolism; Mast cells; Mice; Mice, Transgenic; NC/Nga; Pathogenesis; Rodents; Severity of Illness Index; Skin diseases; Skin lesions; Spleen; Sucrose; SWI3-related gene (SRG3); Th2 cells; Th2 Cells - immunology; Th2 Cells - metabolism; Transcription Factors - genetics; Transgenic mice; Treg cells; Treg cells; atopic dermatitis; Th2 cells; WT; NC/Nga; SWI3-related gene (SRG3)

The SWItch (SWI)3-related gene (SRG3) product, a SWI/Sucrose Non-Fermenting (SNF) chromatin remodeling subunit, plays a critical role in regulating immune responses. We have previously shown that ubiquitous SRG3 overexpression attenuates the progression of Th1/Th17-mediated experimental autoimmune e...