Kidney Cortical Transporter Expression across Species Using Quantitative Proteomics

• Published in: Drug metabolism and disposition Vol. 47; no. 8; pp. 802 - 808
• Main Authors: Basit, Abdul, Radi, Zaher, Vaidya, Vishal S., Karasu, Matthew, Prasad, Bhagwat
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.08.2019; American Society for Pharmacology and Experimental Therapeutics, Inc
• Subjects: Animals; Bile; Dogs; Drug development; Drug Evaluation, Preclinical; Drug interaction; Drug interactions; Female; Gender aspects; Humans; Kidney Cortex - metabolism; Kidneys; Macaca fascicularis; Male; MDR1 protein; Membrane Transport Proteins - analysis; Membrane Transport Proteins - metabolism; Mice; Multidrug resistance; Oct-2 protein; Organic cation transporter; P-Glycoprotein; Pharmacokinetics; Proteins; Proteomics; Rats; Renal cortex; Renal Elimination; Rodents; Scaling; Sex; Sex differences; Sodium; Species; Species Specificity; Toxicity; LC-MS/MS; OCT; MDR1; OAT; sCr; MS; PBPK; CL; MRP; PK

Limited understanding of species differences in kidney transporters is a critical knowledge gap for prediction of drug-induced acute kidney injury, drug interaction, and pharmacokinetics in humans. Here, we report protein abundance data of 19 transporters in the kidney cortex across five species (hu...