Neuroprotection, Recovery of Function and Endogenous Neurogenesis in Traumatic Spinal Cord Injury Following Transplantation of Activated Adipose Tissue

Spinal cord injury (SCI) is a devastating disease, which leads to paralysis and is associated to substantially high costs for the individual and society. At present, no effective therapies are available. Here, the use of mechanically-activated lipoaspirate adipose tissue (MALS) in a murine experimen...

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Published inCells (Basel, Switzerland) Vol. 8; no. 4; p. 329
Main Authors Carelli, Stephana, Giallongo, Toniella, Rey, Federica, Colli, Mattia, Tosi, Delfina, Bulfamante, Gaetano, Di Giulio, Anna Maria, Gorio, Alfredo
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 08.04.2019
MDPI
Subjects
Adipose tissue
Adipose Tissue - cytology
Adipose Tissue - metabolism
Adipose Tissue - transplantation
Animals
Body fat
cell therapies
Clinical outcomes
Contusions
Engraftment
Gene expression
Inflammation
Kinases
Laboratory animals
Male
mechanical activation
Mice
Nestin
Nestin - metabolism
Neurogenesis
Neuroprotection
Paralysis
Patients
Recovery of Function
Spinal cord injuries
Spinal Cord Injuries - therapy
spinal cord injury
Stem cells
Stromal cells
Transplantation
Transplants & implants
United States > US
Italy
mechanical activation
spinal cord injury
inflammation
neuroprotection
adipose tissue
neurogenesis
cell therapies
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Summary:Spinal cord injury (SCI) is a devastating disease, which leads to paralysis and is associated to substantially high costs for the individual and society. At present, no effective therapies are available. Here, the use of mechanically-activated lipoaspirate adipose tissue (MALS) in a murine experimental model of SCI is presented. Our results show that, following acute intraspinal MALS transplantation, there is an engraftment at injury site with the acute powerful inhibition of the posttraumatic inflammatory response, followed by a significant progressive improvement in recovery of function. This is accompanied by spinal cord tissue preservation at the lesion site with the promotion of endogenous neurogenesis as indicated by the significant increase of Nestin-positive cells in perilesional areas. Cells originated from MALS infiltrate profoundly the recipient cord, while the extra-dural fat transplant is gradually impoverished in stromal cells. Altogether, these novel results suggest the potential of MALS application in the promotion of recovery in SCI.
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These authors equally contributed to this work.
ISSN:2073-4409
2073-4409
DOI:10.3390/cells8040329