The Therapeutic Prospects of Targeting IL-1R1 for the Modulation of Neuroinflammation in Central Nervous System Disorders

• Published in: International journal of molecular sciences Vol. 23; no. 3; p. 1731
• Main Authors: Luís, João P., Simões, Carlos J. V., Brito, Rui M. M.
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 02.02.2022; MDPI
• Subjects: Alzheimer's disease; Animals; Central Nervous System Diseases - immunology; Cytokines; Drug therapy; Humans; Immune system; Inflammation; Kinases; Nervous system; Neuroinflammatory Diseases - immunology; Proteins; Receptors, Interleukin-1 Type I - immunology; Regulation; Review; Signal transduction; Tumor necrosis factor-TNF; interleukin-1 receptor type 1; therapeutic target; interleukin-1; neuroinflammation; CNS diseases

The interleukin-1 receptor type 1 (IL-1R1) holds pivotal roles in the immune system, as it is positioned at the “epicenter” of the inflammatory signaling networks. Increased levels of the cytokine IL-1 are a recognized feature of the immune response in the central nervous system (CNS) during injury...