Up-regulation of Fas ligand (FasL) in the central nervous system: A mechanism of immune evasion by rabies virus

• Published in: Journal of neurovirology Vol. 10; no. 6; pp. 372 - 382
• Main Authors: Baloul, Leïla, Camelo, Serge, Lafon, Monique
• Format: Journal Article
• Language: English
• Published: London Informa UK Ltd 01.12.2004; Taylor & Francis
• Subjects: Animal viral diseases; Animals; Apoptosis; Biological and medical sciences; CD3 Complex - metabolism; Cell Movement - immunology; Central Nervous System - immunology; Central Nervous System - pathology; Central Nervous System - virology; Central Nervous System Infections - immunology; Central Nervous System Infections - pathology; Central Nervous System Infections - virology; Fas Ligand Protein; fas Receptor; Human viral diseases; Immunohistochemistry; In Situ Nick-End Labeling; Infectious diseases; Medical sciences; Membrane Glycoproteins - metabolism; Mice; Rabies - immunology; Rabies virus; Rabies virus - immunology; Receptors, Tumor Necrosis Factor - immunology; Receptors, Tumor Necrosis Factor - metabolism; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger - analysis; T-Lymphocytes - immunology; T-Lymphocytes - virology; Up-Regulation; Viral diseases; Viral diseases of the lymphoid tissue and the blood. Aids; Viral diseases of the nervous system; Infection; Virus; rabies virus; Nervous system diseases; immune evasion; Cell death; FasL; Viral disease; Rabies; Central nervous system; CNS; Apoptosis

Following its injection into the hindlimbs of mice, CVS, a highly pathogenic strain of rabies virus, invades the spinal cord and brain resulting in the death of the animal. In contrast, central nervous system (CNS) invasion by PV, a strain of attenuated pathogenicity, is restricted to the spinal cor...