The MHC Class II Transactivator CIITA: Not (Quite) the Odd-One-Out Anymore among NLR Proteins

• Published in: International journal of molecular sciences Vol. 22; no. 3; p. 1074
• Main Authors: León Machado, Jorge Alfonso, Steimle, Viktor
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 22.01.2021; MDPI
• Subjects: Amino acids; Animals; Antigens; Binding; Caspase; CIITA; CIITA protein; Combinatorial analysis; COVID-19 - genetics; COVID-19 - metabolism; Deoxyribonucleic acid; DNA; Ebolavirus - physiology; Gene expression; Gene Expression Regulation; Gene regulation; Genes, MHC Class II; Hemorrhagic Fever, Ebola - genetics; Hemorrhagic Fever, Ebola - metabolism; Homology; Humans; Kinases; Leucine; Major histocompatibility complex; MHC genes; Mutation; Neoplasms - genetics; Neoplasms - metabolism; Nlr protein; NLR Proteins - genetics; NLR Proteins - metabolism; NLRC5; Nuclear Proteins - genetics; Nuclear Proteins - metabolism; Nucleotides; Phosphorylation; Protein interaction; Protein Interaction Maps; Proteins; Review; RNA polymerase; SARS-CoV-2 - physiology; Severe acute respiratory syndrome coronavirus 2; Trans-Activators - genetics; Trans-Activators - metabolism; Transcription; Virus Replication; NLRC5; CIITA; gene regulation; MHC genes

In this review, we discuss the major histocompatibility complex (MHC) class II transactivator (CIITA), which is the master regulator of MHC class II gene expression. CIITA is the founding member of the mammalian nucleotide-binding and leucine-rich-repeat (NLR) protein family but stood apart for a lo...