Circulating Cell-Free mtDNA Contributes to AIM2 Inflammasome-Mediated Chronic Inflammation in Patients with Type 2 Diabetes - Bae, Jung Hwan; Jo, Seung; Kim, Seong Jin; Lee, Jong Min; Jeong, Ji Hun; Kang, Jeong Suk; Cho, Nam-Jun; Kim, Sang Soo; Lee, Eun Young; Moon, Jong-Seok (Cells (Basel, Switzerland), 2019)
Keywords: Aged; AIM2 inflammasome; Alzheimer's disease; Animals; Bone marrow; Cardiovascular disease; Case-Control Studies; Caspase-1; ccf-mtDNA; Cells, Cultured; Chronic illnesses; chronic inflammation; Cloning; Cytokines; Dehydrogenases; Diabetes; Diabetes mellitus (non-insulin dependent); Diabetes Mellitus, Type 2 - metabolism; Diabetes Mellitus, Type 2 - pathology; DNA, Mitochondrial - blood; DNA-Binding Proteins - blood; Enrollments; Female; Health care; Human subjects; Humans; Hyperglycemia; IL-1β; Inflammasomes; Inflammasomes - metabolism; Inflammation; Inflammation - metabolism; Inflammation - pathology; Insulin; Insulin resistance; Interleukin 18; Interleukin-18 - blood; Interleukin-1beta - blood; Kidney diseases; Macrophages; Macrophages - metabolism; Macrophages - pathology; Male; Manufacturers; Melanoma; Middle Aged; Mitochondrial DNA; Plasma; Proteins; type 2 diabetes; Minneapolis Minnesota; United States--US; type 2 diabetes; AIM2 inflammasome; chronic inflammation; ccf-mtDNA