Combination therapy with andrographolide and d-penicillamine enhanced therapeutic advantage over monotherapy with d-penicillamine in attenuating fibrogenic response and cell death in the periportal zone of liver in rats during copper toxicosis - Roy, Dijendra Nath; Sen, Gargi; Chowdhury, Kaustav Dutta; Biswas, Tuli (Toxicology and applied pharmacology, 2011)
Keywords: 60 APPLIED LIFE SCIENCES; adverse effects; Alanine Transaminase - metabolism; ALANINES; AMINO ACIDS; AMINOTRANSFERASES; ANIMAL CELLS; ANIMAL TISSUES; ANIMALS; anti-inflammatory activity; Anti-Inflammatory Agents - therapeutic use; APOPTOSIS; Biological and medical sciences; Biomarkers - metabolism; BODY; CARBOXYLIC ACIDS; caspases; Caspases - metabolism; CELL CONSTITUENTS; CHELATING AGENTS; Chemical and industrial products toxicology. Toxic occupational diseases; CLEARANCE; COPPER; Copper - metabolism; Copper - toxicity; DIGESTIVE SYSTEM; Diterpenes - therapeutic use; Drug Therapy, Combination; DRUGS; ELEMENTS; ENZYMES; EXCRETION; FIBROSIS; GLANDS; hepatocytes; hepatotoxicity; INHIBITION; Kupffer cells; LIVER; Liver - drug effects; Liver - metabolism; Liver - pathology; LIVER CELLS; liver cirrhosis; Liver Cirrhosis - drug therapy; Liver Cirrhosis - metabolism; Male; MAMMALS; Medical sciences; MEDICINE; MEMBRANE PROTEINS; METALS; Metals and various inorganic compounds; MITOCHONDRIA; Mitochondria - drug effects; NECROSIS; NITROGEN TRANSFERASES; ORGANIC ACIDS; ORGANIC COMPOUNDS; ORGANIC SULFUR COMPOUNDS; ORGANS; Oxidative Stress; PATHOLOGICAL CHANGES; PENICILLAMINE; Penicillamine - therapeutic use; poisoning; PROTEINS; Pyruvate Kinase - metabolism; RADIOPROTECTIVE SUBSTANCES; RATS; Rats, Sprague-Dawley; Reactive Oxygen Species - metabolism; RECEPTORS; RESPONSE MODIFYING FACTORS; RETICULOENDOTHELIAL SYSTEM; RODENTS; SAFETY; SOMATIC CELLS; superoxide anion; therapeutics; THERAPY; THIOLS; Toxicology; TRANSFERASES; TRANSITION ELEMENTS; tumor necrosis factor-alpha; urine; VERTEBRATES; Drug combination; TNFα; Rat; Digestive system; Liver; Cytokine; Rodentia; Transition metal; Penicillamine; D-penicillamine; Sulfur containing aminoacid; Vertebrata