Ablation of Galectin-12 Inhibits Atherosclerosis through Enhancement of M2 Macrophage Polarization

• Published in: International journal of molecular sciences Vol. 21; no. 15; p. 5511
• Main Authors: Lin, En-Shyh, Hsu, Yu-An, Chang, Ching-Yao, Lin, Hui-Ju, Chen, Chih Sheng, Wan, Lei
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 31.07.2020; MDPI
• Subjects: ABCA1 protein; Ablation; Adipocytes; Animals; Arteriosclerosis; Atherosclerosis; Atherosclerosis - genetics; Atherosclerosis - metabolism; Atherosclerosis - pathology; ATP Binding Cassette Transporter 1 - genetics; ATP Binding Cassette Transporter, Subfamily G, Member 1 - genetics; ATP-binding protein; Binding; CD163 antigen; CD36 antigen; CD36 Antigens - genetics; Cell Cycle Proteins - genetics; Cell Polarity - genetics; Chemokines; Cholesterol; Chronic illnesses; Coronary vessels; Cytokines; Disease Models, Animal; Doxycycline; foam cell; Foam Cells - metabolism; Foam Cells - pathology; galectin-12; Galectins - genetics; Gene expression; Gene Expression Regulation - genetics; Glucose; Humans; Inflammation; Insulin; Interleukin 6; Kinases; Lipids; Lipolysis; Lipoproteins, LDL - genetics; Lipoproteins, LDL - metabolism; Low density lipoprotein; macrophage polarization; Macrophages; Macrophages - metabolism; Macrophages - pathology; Mice; Mice, Knockout; Monocyte chemoattractant protein; Monocyte chemoattractant protein 1; Monocytes; Pathogenesis; Polarization; Receptors, LDL - genetics; Scavenger receptors; Scavenger Receptors, Class B - genetics; Tumor necrosis factor-α; atherosclerosis; foam cell; macrophage polarization; galectin-12; low-density lipoprotein

The formation of foam cells, which are macrophages that have engulfed oxidized low-density lipoprotein (OxLDL), constitutes the first stage in the development of atherosclerosis. Previously, we found that knocking down galectin-12, a negative regulator of lipolysis, leads to reduced secretion of mon...