Association of plasma P-tau181 with memory decline in non-demented adults

• Published in: Brain communications Vol. 3; no. 3; p. fcab136
• Main Authors: Therriault, Joseph, Benedet, Andrea L, Pascoal, Tharick A, Lussier, Firoza Z, Tissot, Cecile, Karikari, Thomas K, Ashton, Nicholas J, Chamoun, Mira, Bezgin, Gleb, Mathotaarachchi, Sulantha, Gauthier, Serge, Saha-Chaudhuri, Paramita, Zetterberg, Henrik, Blennow, Kaj, Rosa-Neto, Pedro
• Format: Journal Article
• Language: English
• Published: England Oxford University Press 01.07.2021
• Subjects: age; Alzheimer's disease; alzheimers-disease; biomarkers; dementia; memory; mild cognitive impairment; Neurosciences; Neurosciences & Neurology; Neurovetenskaper; Original; plasma; positron-emission-tomography; prediction; randomized-trial; tau; verubecestat; tau; mild cognitive impairment; memory; Alzheimer’s disease; plasma
• ISSN: 2632-1297; 2632-1297
• DOI: 10.1093/braincomms/fcab136

Abstract Alzheimer’s disease is the leading cause of dementia worldwide and is characterized by a long preclinical phase in which amyloid-β and tau accumulate in the absence of cognitive decline. In vivo biomarkers for Alzheimer’s disease are expensive, invasive and inaccessible, yet are critical fo...