Recent Advances of Mesoporous Silica as a Platform for Cancer Immunotherapy

Immunotherapy is a promising modality of treatment for cancer. Immunotherapy is comprised of systemic and local treatments that induce an immune response, allowing the body to fight back against cancer. Systemic treatments such as cancer vaccines harness antigen presenting cells (APCs) to activate T...

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Published inBiosensors (Basel) Vol. 12; no. 2; p. 109
Main Authors Yu, Albert, Dai, Xiaoyong, Wang, Zixian, Chen, Huaqing, Guo, Bing, Huang, Laiqiang
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 10.02.2022
MDPI
Subjects
Antigen (tumor-associated)
Antigen-presenting cells
Antigens
Biocompatibility
Biodistribution
Cancer
Cancer immunotherapy
Cancer vaccines
Cancer Vaccines - immunology
Cancer Vaccines - therapeutic use
Chemotherapy
drug delivery
Drug delivery systems
Humans
Immune checkpoint
Immune response
Immune system
Immunosuppression
Immunotherapy
Laboratories
Lymphocytes
Lymphocytes T
mesoporous silica nanoparticles
Morphology
nanomaterial
Nanomaterials
Nanoparticles
Nanotechnology
Neoplasms - drug therapy
Particle size
Pore size
Porosity
Review
Silica
Silicon Dioxide
Surfactants
Tumors
Vaccines
mesoporous silica nanoparticles
nanomaterial
cancer
drug delivery
immunotherapy
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Abstract Immunotherapy is a promising modality of treatment for cancer. Immunotherapy is comprised of systemic and local treatments that induce an immune response, allowing the body to fight back against cancer. Systemic treatments such as cancer vaccines harness antigen presenting cells (APCs) to activate T cells with tumor-associated antigens. Small molecule inhibitors can be employed to inhibit immune checkpoints, disrupting tumor immunosuppression and immune evasion. Despite the current efficacy of immunotherapy, improvements to delivery can be made. Nanomaterials such as mesoporous silica can facilitate the advancement of immunotherapy. Mesoporous silica has high porosity, decent biocompatibility, and simple surface functionalization. Mesoporous silica can be utilized as a versatile carrier of various immunotherapeutic agents. This review gives an introduction on mesoporous silica as a nanomaterial, briefly covering synthesis and biocompatibility, and then an overview of the recent progress made in the application of mesoporous silica to cancer immunotherapy.
AbstractList Immunotherapy is a promising modality of treatment for cancer. Immunotherapy is comprised of systemic and local treatments that induce an immune response, allowing the body to fight back against cancer. Systemic treatments such as cancer vaccines harness antigen presenting cells (APCs) to activate T cells with tumor-associated antigens. Small molecule inhibitors can be employed to inhibit immune checkpoints, disrupting tumor immunosuppression and immune evasion. Despite the current efficacy of immunotherapy, improvements to delivery can be made. Nanomaterials such as mesoporous silica can facilitate the advancement of immunotherapy. Mesoporous silica has high porosity, decent biocompatibility, and simple surface functionalization. Mesoporous silica can be utilized as a versatile carrier of various immunotherapeutic agents. This review gives an introduction on mesoporous silica as a nanomaterial, briefly covering synthesis and biocompatibility, and then an overview of the recent progress made in the application of mesoporous silica to cancer immunotherapy.
Immunotherapy is a promising modality of treatment for cancer. Immunotherapy is comprised of systemic and local treatments that induce an immune response, allowing the body to fight back against cancer. Systemic treatments such as cancer vaccines harness antigen presenting cells (APCs) to activate T cells with tumor-associated antigens. Small molecule inhibitors can be employed to inhibit immune checkpoints, disrupting tumor immunosuppression and immune evasion. Despite the current efficacy of immunotherapy, improvements to delivery can be made. Nanomaterials such as mesoporous silica can facilitate the advancement of immunotherapy. Mesoporous silica has high porosity, decent biocompatibility, and simple surface functionalization. Mesoporous silica can be utilized as a versatile carrier of various immunotherapeutic agents. This review gives an introduction on mesoporous silica as a nanomaterial, briefly covering synthesis and biocompatibility, and then an overview of the recent progress made in the application of mesoporous silica to cancer immunotherapy.Immunotherapy is a promising modality of treatment for cancer. Immunotherapy is comprised of systemic and local treatments that induce an immune response, allowing the body to fight back against cancer. Systemic treatments such as cancer vaccines harness antigen presenting cells (APCs) to activate T cells with tumor-associated antigens. Small molecule inhibitors can be employed to inhibit immune checkpoints, disrupting tumor immunosuppression and immune evasion. Despite the current efficacy of immunotherapy, improvements to delivery can be made. Nanomaterials such as mesoporous silica can facilitate the advancement of immunotherapy. Mesoporous silica has high porosity, decent biocompatibility, and simple surface functionalization. Mesoporous silica can be utilized as a versatile carrier of various immunotherapeutic agents. This review gives an introduction on mesoporous silica as a nanomaterial, briefly covering synthesis and biocompatibility, and then an overview of the recent progress made in the application of mesoporous silica to cancer immunotherapy.
Author Chen, Huaqing
Wang, Zixian
Guo, Bing
Yu, Albert
Huang, Laiqiang
Dai, Xiaoyong
AuthorAffiliation 3 School of Science and Shenzhen Key Laboratory of Flexible Printed Electronics Technology, Harbin Institute of Technology, Shenzhen 518055, China; guobing2020@hit.edu.cn
2 Shenzhen Key Laboratory of Gene and Antibody Therapy, State Key Laboratory of Chemical Oncogenomics, State Key Laboratory of Health Sciences and Technology, Tsinghua University, Shenzhen 518055, China
1 Precision Medicine and Healthcare Research Center, Tsinghua-Berkeley Shenzhen Institute (TBSI), Shenzhen International Graduate School, Tsinghua University, Shenzhen 518055, China; yxz20@mails.tsinghua.edu.cn (A.Y.); dai-xy18@mails.tsinghua.edu.cn (X.D.); wzx21@mails.tsinghua.edu.cn (Z.W.); chq20@mails.tsinghua.edu.cn (H.C.)
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BackLink https://www.ncbi.nlm.nih.gov/pubmed/35200369$$D View this record in MEDLINE/PubMed
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Cites_doi 10.1016/j.cap.2005.07.019
10.1021/acsnano.9b06691
10.1093/rb/rbab023
10.1016/j.ijpharm.2015.10.080
10.2147/IJN.S142668
10.1021/cm950568k
10.1016/j.biomaterials.2018.02.043
10.1021/nn2013904
10.1016/j.jmst.2020.03.019
10.18632/oncotarget.19187
10.1016/j.apmt.2019.05.006
10.1016/j.cca.2014.05.004
10.1016/j.jcis.2018.01.061
10.1039/C6SC02403C
10.1016/j.msec.2017.03.036
10.1056/NEJMoa1712126
10.1002/adtp.202000130
10.1186/s11671-019-3208-3
10.1016/j.biomaterials.2009.10.046
10.1126/sciadv.aax5032
10.1039/C8RA00033F
10.1021/acsami.0c16728
10.1016/j.ejps.2020.105428
10.3390/ijms22041976
10.1021/la050618s
10.3109/08982104.2016.1166511
10.1016/j.actbio.2018.12.007
10.1021/acsnano.0c08384
10.1080/17425247.2020.1772748
10.1021/cm1017344
10.1007/978-1-4939-3121-7_8
10.18632/oncotarget.2998
10.1021/ja974025i
10.1016/S1470-2045(18)30457-1
10.1016/j.addr.2008.04.012
10.1038/nmat3775
10.1016/j.colsurfb.2020.111452
10.1038/nature10673
10.1021/cm201182d
10.3389/fphar.2020.00898
10.1002/adhm.201501013
10.1016/j.biomaterials.2009.09.060
10.1021/ar000074f
10.1021/jp810360a
10.1021/acsabm.9b00130
10.1002/smll.201803703
10.1016/j.jddst.2019.101184
10.1021/jacs.6b12622
10.1016/j.ejpb.2021.04.020
10.1038/nbt.4047
10.1158/1078-0432.CCR-15-2569
10.1039/c3cs35405a
10.1126/science.1114397
10.1371/journal.pone.0178943
10.1038/nrclinonc.2016.25
10.1021/acsabm.9b01244
10.1002/smll.201904378
10.1016/j.ctrv.2016.02.001
10.1208/s12249-014-0107-x
10.1039/b902681a
10.2147/IJN.S295565
10.1016/j.biomaterials.2018.05.025
10.1002/adhm.201700012
10.1039/C6RA03113G
10.1021/acsami.9b19446
10.1126/science.279.5350.548
10.1038/nbt1340
10.1016/j.biomaterials.2020.119859
10.1021/cm0011559
10.1016/j.actbio.2013.03.031
10.2174/1389557515666150909144606
10.1038/srep05080
10.1002/adhm.201300613
10.1038/nrc1929
10.1021/nn9018834
10.1021/acsami.0c09484
10.1016/j.jcis.2016.11.091
10.1021/ja910846q
10.1016/j.ejpb.2017.07.003
10.1021/acsnano.7b00978
10.1098/rsfs.2017.0030
10.1002/chem.201406137
10.1002/smll.200900005
10.1016/j.ejps.2020.105456
10.1002/anie.201506179
10.1039/C9NA00693A
10.1146/annurev-bioeng-071114-040733
10.1002/adma.19970090317
10.1021/la8010579
10.1016/j.nano.2017.08.006
10.1021/ja0645943
10.1021/nn103077k
10.1002/adma.201802479
10.2147/IJN.S164393
10.1021/acscentsci.8b00035
10.1056/NEJMoa1606774
10.1021/cm0502828
10.1002/smll.200800926
10.1038/emm.2016.44
10.1016/j.urolonc.2007.03.017
10.1021/am300138z
10.1016/j.jcis.2012.06.043
10.1016/j.micromeso.2008.07.002
10.1021/acsami.0c10781
10.1016/j.micromeso.2005.06.012
10.3390/ijms20143422
10.1038/s41467-018-06271-5
10.3390/antib8040055
10.1002/adma.201200446
10.1080/1061186X.2018.1499746
10.1038/s41573-020-0090-8
10.1002/adma.201603239
10.1016/j.jim.2012.05.014
10.1016/j.immuni.2013.07.012
10.1002/smll.201001459
10.2147/IJN.S52605
10.1039/c1cs15246g
10.1021/acsanm.1c02908
10.1021/la101225j
10.2147/IJN.S201688
10.1021/acsabm.9b00483
10.3322/caac.21654
10.1002/smll.201600550
10.2217/nnm-2018-0479
10.1021/acs.nanolett.9b02448
10.1016/j.ccr.2016.04.019
10.1021/acsomega.8b02909
10.1002/pat.5251
10.1038/378366a0
10.1021/acsnano.5b00510
10.1080/17425247.2019.1575806
10.1038/s41568-019-0186-9
10.1016/j.jpba.2019.112989
10.1039/C8NR04042G
10.1021/nn901376h
10.1126/sciadv.aaz4462
10.1016/S0927-7757(01)00638-0
10.1021/cm9703942
10.1016/j.jconrel.2019.07.026
10.3390/ph3040961
10.1246/bcsj.63.988
10.1016/j.jconrel.2018.06.002
10.1002/smll.201300012
10.7150/thno.19987
10.3389/fimmu.2013.00082
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Keywords mesoporous silica nanoparticles
nanomaterial
cancer
drug delivery
immunotherapy
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References 36291049 - Biosensors (Basel). 2022 Sep 27;12(10):794. doi: 10.3390/bios12100794
Yoon (ref_49) 2006; 6
Lin (ref_65) 2010; 132
Yang (ref_102) 2019; 14
Abbaraju (ref_147) 2017; 139
Tarhini (ref_108) 2010; 25
Li (ref_145) 2019; 16
Lee (ref_29) 2020; 12
Wang (ref_40) 2009; 117
Huang (ref_67) 2010; 31
Li (ref_46) 2010; 26
Irvine (ref_113) 2013; 12
Ding (ref_134) 2018; 30
ref_16
Lu (ref_59) 2009; 5
Slowing (ref_72) 2009; 5
Farzin (ref_20) 2020; 179
Kim (ref_37) 2010; 22
Yan (ref_95) 2020; 11
Seth (ref_126) 2020; 12
Mao (ref_99) 2019; 53
Moon (ref_27) 2012; 24
Chen (ref_133) 2020; 12
Attard (ref_31) 1995; 378
Ding (ref_8) 2012; 4
Wang (ref_4) 2017; 8
Motzer (ref_119) 2018; 378
McSweeney (ref_73) 2018; 284
Chen (ref_26) 2021; 63
Zhao (ref_66) 2011; 5
Jin (ref_15) 2020; 15
Trabulo (ref_86) 2010; 3
Wagner (ref_128) 2021; 15
Spain (ref_116) 2016; 44
Hubo (ref_148) 2013; 4
Susanti (ref_48) 2021; 32
Alfredsson (ref_35) 1996; 8
Meng (ref_77) 2015; 9
Zhang (ref_93) 2015; 496
Goldberg (ref_118) 2019; 19
ref_79
Choi (ref_136) 2019; 15
Mellman (ref_107) 2011; 480
Chen (ref_94) 2018; 9
Ong (ref_129) 2019; 2
Mu (ref_61) 2016; 153
Zhao (ref_38) 1998; 279
Cheung (ref_142) 2018; 36
Khalil (ref_111) 2016; 13
Nyugen (ref_135) 2020; 239
Cousin (ref_115) 2016; 22
ref_83
Benlloch (ref_90) 2019; 4
Chen (ref_112) 2013; 39
Li (ref_44) 2008; 24
Xu (ref_125) 2019; 13
Zhang (ref_14) 2019; 15
Zhao (ref_41) 1998; 120
Cooley (ref_68) 2018; 10
Muller (ref_110) 2006; 6
Slowing (ref_75) 2006; 128
Chen (ref_36) 1997; 9
Meng (ref_56) 2012; 384
Guo (ref_12) 2019; 84
Xu (ref_25) 2018; 165
Xu (ref_9) 2017; 490
Bhavsar (ref_19) 2020; 152
Kong (ref_140) 2017; 7
ref_50
Yang (ref_17) 2021; 8
Jo (ref_87) 2016; 48
Park (ref_132) 2020; 3
Akhtar (ref_3) 2014; 436
Lin (ref_106) 2010; 4
Qu (ref_91) 2017; 76
ref_58
Ngamcherdtrakul (ref_92) 2018; 13
Qu (ref_103) 2018; 13
(ref_22) 2001; 13
Feng (ref_53) 2016; 319
Reck (ref_120) 2016; 375
Shen (ref_101) 2019; 14
Narvekar (ref_2) 2014; 15
Yang (ref_57) 2011; 23
Wu (ref_33) 2013; 42
Kumar (ref_39) 2001; 187–188
Alexis (ref_5) 2008; 26
Xu (ref_10) 2019; 1974
Su (ref_51) 2019; 27
Wallis (ref_13) 2020; 152
Hong (ref_130) 2020; 6
Liu (ref_124) 2019; 11
Aly (ref_143) 2012; 382
Zapadka (ref_84) 2017; 7
Xu (ref_138) 2021; 197
Yanagisawa (ref_30) 1990; 63
Ren (ref_55) 2009; 113
Zheng (ref_88) 2020; 17
Ren (ref_54) 2005; 17
Li (ref_98) 2014; 3
Thurber (ref_81) 2008; 60
Nel (ref_105) 2006; 311
Siegel (ref_1) 2021; 71
Miatmoko (ref_7) 2017; 27
Tiller (ref_80) 2015; 17
Fontana (ref_122) 2017; 29
Zhao (ref_137) 2021; 16
Uhl (ref_70) 2018; 8
Xu (ref_52) 2018; 516
Mitchell (ref_63) 2021; 20
Fang (ref_24) 2020; 3
Lu (ref_131) 2018; 175
Wang (ref_64) 2013; 9
Yu (ref_71) 2011; 5
Lyon (ref_117) 2018; 19
He (ref_60) 2011; 7
Qian (ref_121) 2019; 19
Li (ref_45) 2015; 21
Li (ref_139) 2019; 16
Pascual (ref_100) 2017; 13
Duan (ref_127) 2021; 4
Choi (ref_62) 2007; 25
Wang (ref_76) 2010; 4
Gao (ref_89) 2016; 12
Lin (ref_32) 2002; 35
Wang (ref_28) 2016; 55
Brown (ref_69) 2019; 309
Zhu (ref_114) 2017; 11
Gessner (ref_97) 2019; 2
Galluzzi (ref_109) 2014; 5
Mahony (ref_146) 2013; 9
Tan (ref_43) 2005; 21
Li (ref_23) 2012; 41
Huang (ref_104) 2019; 2
Kienzle (ref_141) 2017; 6
Pang (ref_34) 2005; 85
Xu (ref_96) 2016; 6
Chittasupho (ref_11) 2017; 119
Wang (ref_6) 2013; 8
Cha (ref_123) 2018; 4
Chen (ref_42) 2014; 4
Amin (ref_78) 2021; 165
Wang (ref_144) 2016; 5
Lin (ref_47) 2009; 24
Grun (ref_21) 1997; 9
Richards (ref_82) 2017; 8
Huang (ref_18) 2020; 6
Chakravarty (ref_85) 2015; 15
He (ref_74) 2010; 31
References_xml – volume: 6
  start-page: 1059
  year: 2006
  ident: ref_49
  article-title: Template synthesis of nanostructured silica with hollow core and mesoporous shell structures
  publication-title: Curr. Appl. Phys.
  doi: 10.1016/j.cap.2005.07.019
  contributor:
    fullname: Yoon
– volume: 13
  start-page: 12148
  year: 2019
  ident: ref_125
  article-title: Positron Emission Tomography-Guided Photodynamic Therapy with Biodegradable Mesoporous Silica Nanoparticles for Personalized Cancer Immunotherapy
  publication-title: ACS Nano
  doi: 10.1021/acsnano.9b06691
  contributor:
    fullname: Xu
– volume: 8
  start-page: rbab023
  year: 2021
  ident: ref_17
  article-title: Tetraphenylethylene-conjugated polycation covered iron oxide nanoparticles for magnetic resonance/optical dual-mode imaging
  publication-title: Regen Biomater.
  doi: 10.1093/rb/rbab023
  contributor:
    fullname: Yang
– volume: 496
  start-page: 1026
  year: 2015
  ident: ref_93
  article-title: Antibody fragment-armed mesoporous silica nanoparticles for the targeted delivery of bevacizumab in ovarian cancer cells
  publication-title: Int. J. Pharm.
  doi: 10.1016/j.ijpharm.2015.10.080
  contributor:
    fullname: Zhang
– volume: 13
  start-page: 4379
  year: 2018
  ident: ref_103
  article-title: Folic acid-conjugated mesoporous silica nanoparticles for enhanced therapeutic efficacy of topotecan in retina cancers
  publication-title: Int. J. Nanomed.
  doi: 10.2147/IJN.S142668
  contributor:
    fullname: Qu
– volume: 8
  start-page: 1141
  year: 1996
  ident: ref_35
  article-title: Structure of MCM-48 Revealed by Transmission Electron Microscopy
  publication-title: Chem. Mater.
  doi: 10.1021/cm950568k
  contributor:
    fullname: Alfredsson
– volume: 165
  start-page: 56
  year: 2018
  ident: ref_25
  article-title: Bacteria-like mesoporous silica-coated gold nanorods for positron emission tomography and photoacoustic imaging-guided chemo-photothermal combined therapy
  publication-title: Biomaterials
  doi: 10.1016/j.biomaterials.2018.02.043
  contributor:
    fullname: Xu
– volume: 5
  start-page: 5717
  year: 2011
  ident: ref_71
  article-title: Impact of Silica Nanoparticle Design on Cellular Toxicity and Hemolytic Activity
  publication-title: ACS Nano
  doi: 10.1021/nn2013904
  contributor:
    fullname: Yu
– volume: 63
  start-page: 91
  year: 2021
  ident: ref_26
  article-title: Ultra-small MoS2 nanodots-incorporated mesoporous silica nanospheres for pH-sensitive drug delivery and CT imaging
  publication-title: J. Mater. Sci. Technol.
  doi: 10.1016/j.jmst.2020.03.019
  contributor:
    fullname: Chen
– volume: 8
  start-page: 84559
  year: 2017
  ident: ref_4
  article-title: Novel strategies to prevent the development of multidrug resistance (MDR) in cancer
  publication-title: Oncotarget
  doi: 10.18632/oncotarget.19187
  contributor:
    fullname: Wang
– volume: 16
  start-page: 102
  year: 2019
  ident: ref_139
  article-title: Synergistical chemotherapy and cancer immunotherapy using dual drug-delivering and immunopotentiating mesoporous silica
  publication-title: Appl. Mater. Today
  doi: 10.1016/j.apmt.2019.05.006
  contributor:
    fullname: Li
– volume: 436
  start-page: 78
  year: 2014
  ident: ref_3
  article-title: Targeted anticancer therapy: Overexpressed receptors and nanotechnology
  publication-title: Clin. Chim. Acta
  doi: 10.1016/j.cca.2014.05.004
  contributor:
    fullname: Akhtar
– volume: 516
  start-page: 407
  year: 2018
  ident: ref_52
  article-title: Immobilization of Pt nanoparticles in hollow mesoporous silica nanocapsules: An aggregation- and leaching-resistant catalyst
  publication-title: J. Colloid Interface Sci.
  doi: 10.1016/j.jcis.2018.01.061
  contributor:
    fullname: Xu
– volume: 8
  start-page: 63
  year: 2017
  ident: ref_82
  article-title: Antibody fragments as nanoparticle targeting ligands: A step in the right direction
  publication-title: Chem. Sci.
  doi: 10.1039/C6SC02403C
  contributor:
    fullname: Richards
– volume: 76
  start-page: 646
  year: 2017
  ident: ref_91
  article-title: EpCAM antibody-conjugated mesoporous silica nanoparticles to enhance the anticancer efficacy of carboplatin in retinoblastoma
  publication-title: Mater. Sci. Eng. C
  doi: 10.1016/j.msec.2017.03.036
  contributor:
    fullname: Qu
– volume: 378
  start-page: 1277
  year: 2018
  ident: ref_119
  article-title: Nivolumab plus ipilimumab versus sunitinib in advanced renal-cell carcinoma
  publication-title: N. Engl. J. Med.
  doi: 10.1056/NEJMoa1712126
  contributor:
    fullname: Motzer
– volume: 3
  start-page: 2000130
  year: 2020
  ident: ref_132
  article-title: Improving STING Agonist Delivery for Cancer Immunotherapy Using Biodegradable Mesoporous Silica Nanoparticles
  publication-title: Adv. Ther.
  doi: 10.1002/adtp.202000130
  contributor:
    fullname: Park
– volume: 14
  start-page: 390
  year: 2019
  ident: ref_102
  article-title: An efficient cell-targeting drug delivery system based on aptamer-modified mesoporous silica nanoparticles
  publication-title: Nanoscale Res. Lett.
  doi: 10.1186/s11671-019-3208-3
  contributor:
    fullname: Yang
– volume: 31
  start-page: 1085
  year: 2010
  ident: ref_74
  article-title: The effect of PEGylation of mesoporous silica nanoparticles on nonspecific binding of serum proteins and cellular responses
  publication-title: Biomaterials
  doi: 10.1016/j.biomaterials.2009.10.046
  contributor:
    fullname: He
– volume: 6
  start-page: eaax5032
  year: 2020
  ident: ref_18
  article-title: Highly efficient and tumor-selective nanoparticles for dual-targeted immunogene therapy against cancer
  publication-title: Sci. Adv.
  doi: 10.1126/sciadv.aax5032
  contributor:
    fullname: Huang
– volume: 8
  start-page: 8089
  year: 2018
  ident: ref_70
  article-title: The shape effect on polymer nanoparticle transport in a blood vessel
  publication-title: RSC Adv.
  doi: 10.1039/C8RA00033F
  contributor:
    fullname: Uhl
– volume: 12
  start-page: 56741
  year: 2020
  ident: ref_133
  article-title: STING Activator c-di-GMP-Loaded Mesoporous Silica Nanoparticles Enhance Immunotherapy Against Breast Cancer
  publication-title: ACS Appl. Mater. Interfaces
  doi: 10.1021/acsami.0c16728
  contributor:
    fullname: Chen
– volume: 152
  start-page: 105428
  year: 2020
  ident: ref_19
  article-title: Design and characterization of dual responsive mesoporous silica nanoparticles for breast cancer targeted therapy
  publication-title: Eur. J. Pharm. Sci.
  doi: 10.1016/j.ejps.2020.105428
  contributor:
    fullname: Bhavsar
– ident: ref_16
  doi: 10.3390/ijms22041976
– volume: 21
  start-page: 8180
  year: 2005
  ident: ref_43
  article-title: Dual Latex/Surfactant Templating of Hollow Spherical Silica Particles with Ordered Mesoporous Shells
  publication-title: Langmuir
  doi: 10.1021/la050618s
  contributor:
    fullname: Tan
– volume: 27
  start-page: 99
  year: 2017
  ident: ref_7
  article-title: Tumor delivery of liposomal doxorubicin prepared with poly-L-glutamic acid as a drug-trapping agent
  publication-title: J. Liposome Res.
  doi: 10.3109/08982104.2016.1166511
  contributor:
    fullname: Miatmoko
– volume: 84
  start-page: 367
  year: 2019
  ident: ref_12
  article-title: Co-delivery of cisplatin and doxorubicin by covalently conjugating with polyamidoamine dendrimer for enhanced synergistic cancer therapy
  publication-title: Acta Biomater.
  doi: 10.1016/j.actbio.2018.12.007
  contributor:
    fullname: Guo
– volume: 15
  start-page: 4450
  year: 2021
  ident: ref_128
  article-title: Mesoporous Silica Nanoparticles as pH-Responsive Carrier for the Immune-Activating Drug Resiquimod Enhance the Local Immune Response in Mice
  publication-title: ACS Nano
  doi: 10.1021/acsnano.0c08384
  contributor:
    fullname: Wagner
– volume: 17
  start-page: 1059
  year: 2020
  ident: ref_88
  article-title: Molecular targeted nanotheranostics for future individualized cancer treatment
  publication-title: Expert Opin. Drug Deliv.
  doi: 10.1080/17425247.2020.1772748
  contributor:
    fullname: Zheng
– volume: 22
  start-page: 5093
  year: 2010
  ident: ref_37
  article-title: Facile Synthesis of Monodisperse Spherical MCM-48 Mesoporous Silica Nanoparticles with Controlled Particle Size
  publication-title: Chem. Mater.
  doi: 10.1021/cm1017344
  contributor:
    fullname: Kim
– volume: 153
  start-page: 153
  year: 2016
  ident: ref_61
  article-title: Silicon Nanoparticles and Microparticles
  publication-title: Nanomater. Pharm.
  doi: 10.1007/978-1-4939-3121-7_8
  contributor:
    fullname: Mu
– volume: 5
  start-page: 12472
  year: 2014
  ident: ref_109
  article-title: Classification of current anticancer immunotherapies
  publication-title: Oncotarget
  doi: 10.18632/oncotarget.2998
  contributor:
    fullname: Galluzzi
– volume: 120
  start-page: 6024
  year: 1998
  ident: ref_41
  article-title: Nonionic Triblock and Star Diblock Copolymer and Oligomeric Surfactant Syntheses of Highly Ordered, Hydrothermally Stable, Mesoporous Silica Structures
  publication-title: J. Am. Chem. Soc.
  doi: 10.1021/ja974025i
  contributor:
    fullname: Zhao
– volume: 19
  start-page: 447
  year: 2018
  ident: ref_117
  article-title: Immune checkpoint inhibitors and cardiovascular toxicity
  publication-title: Lancet Oncol.
  doi: 10.1016/S1470-2045(18)30457-1
  contributor:
    fullname: Lyon
– volume: 60
  start-page: 1421
  year: 2008
  ident: ref_81
  article-title: Antibody tumor penetration: Transport opposed by systemic and antigen-mediated clearance
  publication-title: Adv. Drug Deliv. Rev.
  doi: 10.1016/j.addr.2008.04.012
  contributor:
    fullname: Thurber
– volume: 12
  start-page: 978
  year: 2013
  ident: ref_113
  article-title: Engineering synthetic vaccines using cues from natural immunity
  publication-title: Nat Mater.
  doi: 10.1038/nmat3775
  contributor:
    fullname: Irvine
– volume: 197
  start-page: 111452
  year: 2021
  ident: ref_138
  article-title: Virus-like hollow mesoporous silica nanoparticles for cancer combination therapy
  publication-title: Colloids Surf. B
  doi: 10.1016/j.colsurfb.2020.111452
  contributor:
    fullname: Xu
– volume: 480
  start-page: 480
  year: 2011
  ident: ref_107
  article-title: Cancer immunotherapy comes of age
  publication-title: Nature
  doi: 10.1038/nature10673
  contributor:
    fullname: Mellman
– volume: 23
  start-page: 3676
  year: 2011
  ident: ref_57
  article-title: Organosilane-Assisted Transformation from Core–Shell to Yolk–Shell Nanocomposites
  publication-title: Chem. Mater.
  doi: 10.1021/cm201182d
  contributor:
    fullname: Yang
– volume: 11
  start-page: 898
  year: 2020
  ident: ref_95
  article-title: Preparation of RGD peptide/folate acid double-targeted mesoporous silica nanoparticles and its application in human breast cancer MCF-7 cells
  publication-title: Front. Pharmacol.
  doi: 10.3389/fphar.2020.00898
  contributor:
    fullname: Yan
– volume: 5
  start-page: 1169
  year: 2016
  ident: ref_144
  article-title: Comprehensive Mechanism Analysis of Mesoporous-Silica-Nanoparticle-Induced Cancer Immunotherapy
  publication-title: Adv. Healthc. Mater.
  doi: 10.1002/adhm.201501013
  contributor:
    fullname: Wang
– volume: 31
  start-page: 438
  year: 2010
  ident: ref_67
  article-title: The effect of the shape of mesoporous silica nanoparticles on cellular uptake and cell function
  publication-title: Biomaterials
  doi: 10.1016/j.biomaterials.2009.09.060
  contributor:
    fullname: Huang
– volume: 35
  start-page: 927
  year: 2002
  ident: ref_32
  article-title: Structural and Morphological Control of Cationic Surfactant-Templated Mesoporous Silica
  publication-title: Acc. Chem. Res.
  doi: 10.1021/ar000074f
  contributor:
    fullname: Lin
– volume: 113
  start-page: 3168
  year: 2009
  ident: ref_55
  article-title: A self-templated route to hollow silica microspheres
  publication-title: J. Phys. Chem. C
  doi: 10.1021/jp810360a
  contributor:
    fullname: Ren
– volume: 2
  start-page: 2421
  year: 2019
  ident: ref_104
  article-title: Hyaluronic acid nanoparticles based on a conjugated oligomer photosensitizer: Target-specific two-photon imaging, redox-sensitive drug delivery, and synergistic chemo-photodynamic therapy
  publication-title: ACS Appl. Bio Mater.
  doi: 10.1021/acsabm.9b00130
  contributor:
    fullname: Huang
– volume: 15
  start-page: 1803703
  year: 2019
  ident: ref_14
  article-title: Holo-Lactoferrin Modified Liposome for Relieving Tumor Hypoxia and Enhancing Radiochemotherapy of Cancer
  publication-title: Small
  doi: 10.1002/smll.201803703
  contributor:
    fullname: Zhang
– volume: 53
  start-page: 101184
  year: 2019
  ident: ref_99
  article-title: Thiolated polymer and Cell-Penetrating Peptide dual-surface functionalization of mesoporous silicon nanoparticles to overcome intestinal barriers
  publication-title: J. Drug Deliv. Sci. Technol.
  doi: 10.1016/j.jddst.2019.101184
  contributor:
    fullname: Mao
– volume: 139
  start-page: 6321
  year: 2017
  ident: ref_147
  article-title: Asymmetric Silica Nanoparticles with Tunable Head–Tail Structures Enhance Hemocompatibility and Maturation of Immune Cells
  publication-title: J. Am. Chem. Soc.
  doi: 10.1021/jacs.6b12622
  contributor:
    fullname: Abbaraju
– volume: 165
  start-page: 31
  year: 2021
  ident: ref_78
  article-title: Enhanced efficacy and drug delivery with lipid coated mesoporous silica nanoparticles in cancer therapy
  publication-title: Eur. J. Pharm. Biopharm.
  doi: 10.1016/j.ejpb.2021.04.020
  contributor:
    fullname: Amin
– volume: 36
  start-page: 160
  year: 2018
  ident: ref_142
  article-title: Scaffolds that mimic antigen-presenting cells enable ex vivo expansion of primary T cells
  publication-title: Nat. Biotechnol.
  doi: 10.1038/nbt.4047
  contributor:
    fullname: Cheung
– volume: 22
  start-page: 4550
  year: 2016
  ident: ref_115
  article-title: Molecular pathways: Immune checkpoint antibodies and their toxicities
  publication-title: Clin. Cancer Res.
  doi: 10.1158/1078-0432.CCR-15-2569
  contributor:
    fullname: Cousin
– volume: 42
  start-page: 3862
  year: 2013
  ident: ref_33
  article-title: Synthesis of mesoporous silica nanoparticles
  publication-title: Chem. Soc. Rev.
  doi: 10.1039/c3cs35405a
  contributor:
    fullname: Wu
– volume: 311
  start-page: 622
  year: 2006
  ident: ref_105
  article-title: Toxic Potential of Materials at the Nanolevel
  publication-title: Science
  doi: 10.1126/science.1114397
  contributor:
    fullname: Nel
– ident: ref_83
  doi: 10.1371/journal.pone.0178943
– volume: 13
  start-page: 273
  year: 2016
  ident: ref_111
  article-title: The future of cancer treatment: Immunomodulation, CARs and combination immunotherapy
  publication-title: Nat. Rev. Clin. Oncol.
  doi: 10.1038/nrclinonc.2016.25
  contributor:
    fullname: Khalil
– volume: 3
  start-page: 1690
  year: 2020
  ident: ref_24
  article-title: MRI Enhancement and Tumor Targeted Drug Delivery Using Zn2+-Doped Fe3O4 Core/Mesoporous Silica Shell Nanocomposites
  publication-title: ACS Appl. Bio Mater.
  doi: 10.1021/acsabm.9b01244
  contributor:
    fullname: Fang
– volume: 15
  start-page: e1904378
  year: 2019
  ident: ref_136
  article-title: Sequential MR Image-Guided Local Immune Checkpoint Blockade Cancer Immunotherapy Using Ferumoxytol Capped Ultralarge Pore Mesoporous Silica Carriers after Standard Chemotherapy
  publication-title: Small
  doi: 10.1002/smll.201904378
  contributor:
    fullname: Choi
– volume: 44
  start-page: 51
  year: 2016
  ident: ref_116
  article-title: Management of toxicities of immune checkpoint inhibitors
  publication-title: Cancer Treat. Rev.
  doi: 10.1016/j.ctrv.2016.02.001
  contributor:
    fullname: Spain
– volume: 15
  start-page: 822
  year: 2014
  ident: ref_2
  article-title: Nanocarrier for poorly water-soluble anticancer drugs—barriers of translation and solutions
  publication-title: AAPS PharmSciTech
  doi: 10.1208/s12249-014-0107-x
  contributor:
    fullname: Narvekar
– volume: 24
  start-page: 3542
  year: 2009
  ident: ref_47
  article-title: Synthesis of hollow silica nanospheres with a microemulsion as the template
  publication-title: Chem. Commun.
  doi: 10.1039/b902681a
  contributor:
    fullname: Lin
– volume: 16
  start-page: 2107
  year: 2021
  ident: ref_137
  article-title: Cancer Cell Membrane Camouflaged Mesoporous Silica Nanoparticles Combined with Immune Checkpoint Blockade for Regulating Tumor Microenvironment and Enhancing Antitumor Therapy
  publication-title: Int. J. Nanomed.
  doi: 10.2147/IJN.S295565
  contributor:
    fullname: Zhao
– volume: 175
  start-page: 82
  year: 2018
  ident: ref_131
  article-title: Glutathione-depletion mesoporous organosilica nanoparticles as a self-adjuvant and Co-delivery platform for enhanced cancer immunotherapy
  publication-title: Biomaterials
  doi: 10.1016/j.biomaterials.2018.05.025
  contributor:
    fullname: Lu
– volume: 6
  start-page: 1700012
  year: 2017
  ident: ref_141
  article-title: Dendritic Mesoporous Silica Nanoparticles for pH-Stimuli-Responsive Drug Delivery of TNF-Alpha
  publication-title: Adv. Healthc. Mater.
  doi: 10.1002/adhm.201700012
  contributor:
    fullname: Kienzle
– volume: 6
  start-page: 40427
  year: 2016
  ident: ref_96
  article-title: Preparation and characterization of a dual-receptor mesoporous silica nanoparticle–hyaluronic acid–RGD peptide targeting drug delivery system
  publication-title: RSC Adv.
  doi: 10.1039/C6RA03113G
  contributor:
    fullname: Xu
– volume: 11
  start-page: 47798
  year: 2019
  ident: ref_124
  article-title: Polyethylenimine Hybrid Thin-Shell Hollow Mesoporous Silica Nanoparticles as Vaccine Self-Adjuvants for Cancer Immunotherapy
  publication-title: ACS Appl. Mater. Interfaces
  doi: 10.1021/acsami.9b19446
  contributor:
    fullname: Liu
– volume: 279
  start-page: 548
  year: 1998
  ident: ref_38
  article-title: Triblock Copolymer Syntheses of Mesoporous Silica with Periodic 50 to 300 Angstrom Pores
  publication-title: Science
  doi: 10.1126/science.279.5350.548
  contributor:
    fullname: Zhao
– volume: 25
  start-page: 1165
  year: 2007
  ident: ref_62
  article-title: Renal Clearance of Nanoparticles
  publication-title: Nat. Biotechnol.
  doi: 10.1038/nbt1340
  contributor:
    fullname: Choi
– volume: 239
  start-page: 119859
  year: 2020
  ident: ref_135
  article-title: Injectable dual-scale mesoporous silica cancer vaccine enabling efficient delivery of antigen/adjuvant-loaded nanoparticles to dendritic cells recruited in local macroporous scaffold
  publication-title: Biomaterials
  doi: 10.1016/j.biomaterials.2020.119859
  contributor:
    fullname: Nyugen
– volume: 13
  start-page: 308
  year: 2001
  ident: ref_22
  article-title: A new property of MCM-41: Drug delivery system
  publication-title: Chem. Mater.
  doi: 10.1021/cm0011559
– volume: 9
  start-page: 7480
  year: 2013
  ident: ref_64
  article-title: Particle-size-dependent toxicity and immunogenic activity of mesoporous silica-based adjuvants for tumor immunotherapy
  publication-title: Acta Biomater.
  doi: 10.1016/j.actbio.2013.03.031
  contributor:
    fullname: Wang
– volume: 15
  start-page: 1073
  year: 2015
  ident: ref_85
  article-title: Molecular imaging of breast cancer: Role of RGD peptides
  publication-title: Mini-Rev. Med. Chem.
  doi: 10.2174/1389557515666150909144606
  contributor:
    fullname: Chakravarty
– volume: 4
  start-page: 5080
  year: 2014
  ident: ref_42
  article-title: Engineering of Hollow Mesoporous Silica Nanoparticles for Remarkably Enhanced Tumor Active Targeting Efficacy
  publication-title: Sci. Rep.
  doi: 10.1038/srep05080
  contributor:
    fullname: Chen
– volume: 3
  start-page: 1230
  year: 2014
  ident: ref_98
  article-title: Enzyme-responsive cell-penetrating peptide conjugated mesoporous silica quantum dot nanocarriers for controlled release of nucleus-targeted drug molecules and real-time intracellular fluorescence imaging of tumor cells
  publication-title: Adv. Healthc. Mater.
  doi: 10.1002/adhm.201300613
  contributor:
    fullname: Li
– volume: 6
  start-page: 613
  year: 2006
  ident: ref_110
  article-title: Targeting the mechanisms of tumoral immune tolerance with small-molecule inhibitors
  publication-title: Nat. Rev. Cancer
  doi: 10.1038/nrc1929
  contributor:
    fullname: Muller
– volume: 4
  start-page: 3363
  year: 2010
  ident: ref_106
  article-title: Functional Assessment of Metal Oxide Nanoparticle Toxicity in Immune Cells
  publication-title: ACS Nano
  doi: 10.1021/nn9018834
  contributor:
    fullname: Lin
– volume: 12
  start-page: 34658
  year: 2020
  ident: ref_29
  article-title: Hollow Mesoporous Silica Nanoparticles with Extra-Large Mesopores for Enhanced Cancer Vaccine
  publication-title: ACS Appl. Mater. Interfaces
  doi: 10.1021/acsami.0c09484
  contributor:
    fullname: Lee
– volume: 490
  start-page: 511
  year: 2017
  ident: ref_9
  article-title: pH-responsive polymeric micelles based on poly(ethyleneglycol)-b-poly(2-(diisopropylamino) ethyl methacrylate) block copolymer for enhanced intracellular release of anticancer drugs
  publication-title: J. Colloid Interface Sci.
  doi: 10.1016/j.jcis.2016.11.091
  contributor:
    fullname: Xu
– volume: 132
  start-page: 4834
  year: 2010
  ident: ref_65
  article-title: Impacts of Mesoporous Silica Nanoparticle Size, Pore Ordering, and Pore Integrity on Hemolytic Activity
  publication-title: J. Am. Chem. Soc.
  doi: 10.1021/ja910846q
  contributor:
    fullname: Lin
– volume: 119
  start-page: 310
  year: 2017
  ident: ref_11
  article-title: CXCR4 targeted dendrimer for anti-cancer drug delivery and breast cancer cell migration inhibition
  publication-title: Eur. J. Pharm. Biopharm.
  doi: 10.1016/j.ejpb.2017.07.003
  contributor:
    fullname: Chittasupho
– volume: 11
  start-page: 2387
  year: 2017
  ident: ref_114
  article-title: Efficient nanovaccine delivery in cancer immunotherapy
  publication-title: ACS Nano
  doi: 10.1021/acsnano.7b00978
  contributor:
    fullname: Zhu
– volume: 7
  start-page: 20170030
  year: 2017
  ident: ref_84
  article-title: Factors affecting the physical stability (aggregation) of peptide therapeutics
  publication-title: Interface Focus
  doi: 10.1098/rsfs.2017.0030
  contributor:
    fullname: Zapadka
– volume: 21
  start-page: 6375
  year: 2015
  ident: ref_45
  article-title: Dual soft-template system based on colloidal chemistry for the synthesis of hollow mesoporous silica nanoparticles
  publication-title: Chemistry
  doi: 10.1002/chem.201406137
  contributor:
    fullname: Li
– volume: 5
  start-page: 1408
  year: 2009
  ident: ref_59
  article-title: Size Effect on Cell Uptake in Well-Suspended, Uniform Mesoporous Silica Nanoparticles
  publication-title: Small
  doi: 10.1002/smll.200900005
  contributor:
    fullname: Lu
– volume: 152
  start-page: 105456
  year: 2020
  ident: ref_13
  article-title: A liposome-based cancer vaccine for a rapid and high-titre anti-ErbB-2 antibody response
  publication-title: Eur. J. Pharm. Sci.
  doi: 10.1016/j.ejps.2020.105456
  contributor:
    fullname: Wallis
– volume: 55
  start-page: 1899
  year: 2016
  ident: ref_28
  article-title: Stimulation of In Vivo Antitumor Immunity with Hollow Mesoporous Silica Nanospheres
  publication-title: Angew. Chem. Int. Ed.
  doi: 10.1002/anie.201506179
  contributor:
    fullname: Wang
– ident: ref_58
– volume: 2
  start-page: 453
  year: 2019
  ident: ref_97
  article-title: Interdependence of charge and secondary structure on cellular uptake of cell penetrating peptide functionalized silica nanoparticles
  publication-title: Nanoscale Adv.
  doi: 10.1039/C9NA00693A
  contributor:
    fullname: Gessner
– volume: 17
  start-page: 191
  year: 2015
  ident: ref_80
  article-title: Advances in antibody design
  publication-title: Annu Rev Biomed Eng.
  doi: 10.1146/annurev-bioeng-071114-040733
  contributor:
    fullname: Tiller
– volume: 9
  start-page: 254
  year: 1997
  ident: ref_21
  article-title: The synthesis of micrometer- and submicrometer-size spheres of ordered mesoporous oxide MCM-41
  publication-title: Adv. Mater.
  doi: 10.1002/adma.19970090317
  contributor:
    fullname: Grun
– volume: 24
  start-page: 9050
  year: 2008
  ident: ref_44
  article-title: pH-Responsive Hollow Polymeric Microspheres and Concentric Hollow Silica Microspheres from Silica−Polymer Core−Shell Microspheres
  publication-title: Langmuir
  doi: 10.1021/la8010579
  contributor:
    fullname: Li
– volume: 13
  start-page: 2495
  year: 2017
  ident: ref_100
  article-title: MUC1 aptamer-capped mesoporous silica nanoparticles for controlled drug delivery and radio-imaging applications
  publication-title: Nanomed. Nanotechnol. Biol. Med.
  doi: 10.1016/j.nano.2017.08.006
  contributor:
    fullname: Pascual
– volume: 128
  start-page: 14792
  year: 2006
  ident: ref_75
  article-title: Effect of Surface Functionalization of MCM-41-Type Mesoporous Silica Nanoparticles on the Endocytosis by Human Cancer Cells
  publication-title: J. Am. Chem. Soc.
  doi: 10.1021/ja0645943
  contributor:
    fullname: Slowing
– volume: 5
  start-page: 1366
  year: 2011
  ident: ref_66
  article-title: Interaction of Mesoporous Silica Nanoparticles with Human Red Blood Cell Membranes: Size and Surface Effects
  publication-title: ACS Nano
  doi: 10.1021/nn103077k
  contributor:
    fullname: Zhao
– volume: 30
  start-page: e1802479
  year: 2018
  ident: ref_134
  article-title: Large-Pore Mesoporous-Silica-Coated Upconversion Nanoparticles as Multifunctional Immunoadjuvants with Ultrahigh Photosensitizer and Antigen Loading Efficiency for Improved Cancer Photodynamic Immunotherapy
  publication-title: Adv. Mater.
  doi: 10.1002/adma.201802479
  contributor:
    fullname: Ding
– volume: 13
  start-page: 4015
  year: 2018
  ident: ref_92
  article-title: Lyophilization and stability of antibody-conjugated mesoporous silica nanoparticle with cationic polymer and PEG for siRNA delivery
  publication-title: Int. J. Nanomed.
  doi: 10.2147/IJN.S164393
  contributor:
    fullname: Ngamcherdtrakul
– volume: 4
  start-page: 484
  year: 2018
  ident: ref_123
  article-title: Extra-Large Pore Mesoporous Silica Nanoparticles Enabling Co-Delivery of High Amounts of Protein Antigen and Toll-like Receptor 9 Agonist for Enhanced Cancer Vaccine Efficacy
  publication-title: ACS Cent. Sci.
  doi: 10.1021/acscentsci.8b00035
  contributor:
    fullname: Cha
– volume: 375
  start-page: 1823
  year: 2016
  ident: ref_120
  article-title: Pembrolizumab versus chemotherapy for PD-L1-positive non-small-cell lung cancer
  publication-title: N. Engl. J. Med.
  doi: 10.1056/NEJMoa1606774
  contributor:
    fullname: Reck
– volume: 25
  start-page: 601
  year: 2010
  ident: ref_108
  article-title: Releasing the brake on the immune system: Ipilimumab in melanoma and other tumors
  publication-title: Cancer Biother. Radiopharm.
  contributor:
    fullname: Tarhini
– volume: 17
  start-page: 2582
  year: 2005
  ident: ref_54
  article-title: General method for the fabrication of hollow microcapsules with adjustable shell compositions
  publication-title: Chem. Mater.
  doi: 10.1021/cm0502828
  contributor:
    fullname: Ren
– volume: 5
  start-page: 57
  year: 2009
  ident: ref_72
  article-title: Mesoporous Silica Nanoparticles for Reducing Hemolytic Activity Towards Mammalian Red Blood Cells
  publication-title: Small
  doi: 10.1002/smll.200800926
  contributor:
    fullname: Slowing
– volume: 48
  start-page: e230
  year: 2016
  ident: ref_87
  article-title: Aptamer–nanoparticle complexes as powerful diagnostic and therapeutic tools
  publication-title: Exp. Mol. Med.
  doi: 10.1038/emm.2016.44
  contributor:
    fullname: Jo
– volume: 26
  start-page: 74
  year: 2008
  ident: ref_5
  article-title: New frontiers in nanotechnology for cancer treatment
  publication-title: Urol. Oncol.
  doi: 10.1016/j.urolonc.2007.03.017
  contributor:
    fullname: Alexis
– volume: 4
  start-page: 1838
  year: 2012
  ident: ref_8
  article-title: Tumor accumulation, penetration, and antitumor response of cisplatin-loaded gelatin/poly(acrylic acid) nanoparticles
  publication-title: ACS Appl. Mater. Interfaces
  doi: 10.1021/am300138z
  contributor:
    fullname: Ding
– volume: 384
  start-page: 22
  year: 2012
  ident: ref_56
  article-title: A facile two-step etching method to fabricate porous hollow silica particles
  publication-title: J. Colloid Interface Sci.
  doi: 10.1016/j.jcis.2012.06.043
  contributor:
    fullname: Meng
– volume: 117
  start-page: 1
  year: 2009
  ident: ref_40
  article-title: Ordered mesoporous materials for drug delivery
  publication-title: Microporous Mesoporous Mater.
  doi: 10.1016/j.micromeso.2008.07.002
  contributor:
    fullname: Wang
– volume: 12
  start-page: 42499
  year: 2020
  ident: ref_126
  article-title: Polydopamine-Mesoporous Silica Core-Shell Nanoparticles for Combined Photothermal-Immunotherapy
  publication-title: ACS Appl. Mater. Interfaces
  doi: 10.1021/acsami.0c10781
  contributor:
    fullname: Seth
– volume: 85
  start-page: 1
  year: 2005
  ident: ref_34
  article-title: Morphological control of mesoporous materials using inexpensive silica sources
  publication-title: Microporous Mesoporous Mater.
  doi: 10.1016/j.micromeso.2005.06.012
  contributor:
    fullname: Pang
– ident: ref_50
  doi: 10.3390/ijms20143422
– volume: 9
  start-page: 4141
  year: 2018
  ident: ref_94
  article-title: Ultrasmall targeted nanoparticles with engineered antibody fragments for imaging detection of HER2-overexpressing breast cancer
  publication-title: Nat Commun.
  doi: 10.1038/s41467-018-06271-5
  contributor:
    fullname: Chen
– ident: ref_79
  doi: 10.3390/antib8040055
– volume: 24
  start-page: 3724
  year: 2012
  ident: ref_27
  article-title: Engineering nano- and microparticles to tune immunity
  publication-title: Adv Mater.
  doi: 10.1002/adma.201200446
  contributor:
    fullname: Moon
– volume: 27
  start-page: 201
  year: 2019
  ident: ref_51
  article-title: Mesoporous silica-coated gold nanostars with drug payload for combined chemo-photothermal cancer therapy
  publication-title: J. Drug Target.
  doi: 10.1080/1061186X.2018.1499746
  contributor:
    fullname: Su
– volume: 20
  start-page: 101
  year: 2021
  ident: ref_63
  article-title: Engineering precision nanoparticles for drug delivery
  publication-title: Nat. Rev. Drug Discov.
  doi: 10.1038/s41573-020-0090-8
  contributor:
    fullname: Mitchell
– volume: 29
  start-page: 1603239
  year: 2017
  ident: ref_122
  article-title: Multistaged Nanovaccines Based on Porous Silicon@Acetalated Dextran@Cancer Cell Membrane for Cancer Immunotherapy
  publication-title: Adv Mater.
  doi: 10.1002/adma.201603239
  contributor:
    fullname: Fontana
– volume: 382
  start-page: 1
  year: 2012
  ident: ref_143
  article-title: Cancer Therapy and Vaccination
  publication-title: J. Immunol. Methods
  doi: 10.1016/j.jim.2012.05.014
  contributor:
    fullname: Aly
– volume: 39
  start-page: 1
  year: 2013
  ident: ref_112
  article-title: Oncology Meets Immunology: The Cancer-Immunity Cycle
  publication-title: Immunity
  doi: 10.1016/j.immuni.2013.07.012
  contributor:
    fullname: Chen
– volume: 7
  start-page: 271
  year: 2011
  ident: ref_60
  article-title: In vivo Biodistribution and Urinary Excretion of Mesoporous Silica Nanoparticles: Effects of Particle Size and PEGylation
  publication-title: Small
  doi: 10.1002/smll.201001459
  contributor:
    fullname: He
– volume: 8
  start-page: 4015
  year: 2013
  ident: ref_6
  article-title: Ordered nanoporous silica as carriers for improved delivery of water insoluble drugs: A comparative study between three dimensional and two dimensional macroporous silica
  publication-title: Int. J. Nanomed.
  doi: 10.2147/IJN.S52605
  contributor:
    fullname: Wang
– volume: 41
  start-page: 2590
  year: 2012
  ident: ref_23
  article-title: Mesoporous silica nanoparticles in biomedical applications
  publication-title: Chem. Soc. Rev.
  doi: 10.1039/c1cs15246g
  contributor:
    fullname: Li
– volume: 4
  start-page: 13398
  year: 2021
  ident: ref_127
  article-title: pH-Responsive Metal–Organic Framework-Coated Mesoporous Silica Nanoparticles for Immunotherapy
  publication-title: ACS Appl. Nano Mater.
  doi: 10.1021/acsanm.1c02908
  contributor:
    fullname: Duan
– volume: 26
  start-page: 12267
  year: 2010
  ident: ref_46
  article-title: Interfacially Controlled Synthesis of Hollow Mesoporous Silica Spheres with Radially Oriented Pore Structures
  publication-title: Langmuir
  doi: 10.1021/la101225j
  contributor:
    fullname: Li
– volume: 14
  start-page: 4029
  year: 2019
  ident: ref_101
  article-title: A dual-functional HER2 aptamer-conjugated, pH-activated mesoporous silica nanocarrier-based drug delivery system provides in vitro synergistic cytotoxicity in HER2-positive breast cancer cells
  publication-title: Int. J. Nanomed.
  doi: 10.2147/IJN.S201688
  contributor:
    fullname: Shen
– volume: 2
  start-page: 3630
  year: 2019
  ident: ref_129
  article-title: Mesoporous Silica Nanoparticles Doped with Gold Nanoparticles for Combined Cancer Immunotherapy and Photothermal Therapy
  publication-title: ACS Appl. Bio Mater.
  doi: 10.1021/acsabm.9b00483
  contributor:
    fullname: Ong
– volume: 71
  start-page: 7
  year: 2021
  ident: ref_1
  article-title: Cancer Statistics, 2021
  publication-title: CA Cancer J Clin.
  doi: 10.3322/caac.21654
  contributor:
    fullname: Siegel
– volume: 12
  start-page: 2595
  year: 2016
  ident: ref_89
  article-title: The architecture and function of monoclonal antibody-functionalized mesoporous silica nanoparticles loaded with mifepristone: Repurposing abortifacient for cancer metastatic chemoprevention
  publication-title: Small
  doi: 10.1002/smll.201600550
  contributor:
    fullname: Gao
– volume: 15
  start-page: 41
  year: 2020
  ident: ref_15
  article-title: A cocktail of betulinic acid, parthenolide, honokiol and ginsenoside Rh2 in liposome systems for lung cancer treatment
  publication-title: Nanomedicine
  doi: 10.2217/nnm-2018-0479
  contributor:
    fullname: Jin
– volume: 19
  start-page: 8409
  year: 2019
  ident: ref_121
  article-title: Biodegradable Mesoporous Silica Achieved via Carbon Nanodots-Incorporated Framework Swelling for Debris-Mediated Photothermal Synergistic Immunotherapy
  publication-title: Nano Lett.
  doi: 10.1021/acs.nanolett.9b02448
  contributor:
    fullname: Qian
– volume: 319
  start-page: 86
  year: 2016
  ident: ref_53
  article-title: The application of mesoporous silica nanoparticle family in cancer theranostics
  publication-title: Coord. Chem. Rev.
  doi: 10.1016/j.ccr.2016.04.019
  contributor:
    fullname: Feng
– volume: 4
  start-page: 1281
  year: 2019
  ident: ref_90
  article-title: PSMA-targeted mesoporous silica nanoparticles for selective intracellular delivery of docetaxel in prostate cancer cells
  publication-title: ACS Omega
  doi: 10.1021/acsomega.8b02909
  contributor:
    fullname: Benlloch
– volume: 32
  start-page: 1965
  year: 2021
  ident: ref_48
  article-title: How to develop molecularly imprinted mesoporous silica for selective recognition of analytes in pharmaceutical, environmental, and food samples
  publication-title: Polym. Adv. Technol.
  doi: 10.1002/pat.5251
  contributor:
    fullname: Susanti
– volume: 1974
  start-page: 398
  year: 2019
  ident: ref_10
  article-title: Folate-Decorated Polyamidoamine Dendrimer Nanoparticles for Head and Neck Cancer Gene Therapy
  publication-title: Methods Mol. Biol.
  contributor:
    fullname: Xu
– volume: 378
  start-page: 366
  year: 1995
  ident: ref_31
  article-title: Liquid-crystalline phases as templates for the synthesis of mesoporous silica
  publication-title: Nature
  doi: 10.1038/378366a0
  contributor:
    fullname: Attard
– volume: 9
  start-page: 3540
  year: 2015
  ident: ref_77
  article-title: Use of a Lipid-Coated Mesoporous Silica Nanoparticle Platform for Synergistic Gemcitabine and Paclitaxel Delivery to Human Pancreatic Cancer in Mice
  publication-title: ACS Nano
  doi: 10.1021/acsnano.5b00510
  contributor:
    fullname: Meng
– volume: 16
  start-page: 219
  year: 2019
  ident: ref_145
  article-title: Mesoporous silica nanoparticles: Synthesis, classification, drug loading, pharmacokinetics, biocompatibility, and application in drug delivery
  publication-title: Expert Opin. Drug Deliv.
  doi: 10.1080/17425247.2019.1575806
  contributor:
    fullname: Li
– volume: 19
  start-page: 587
  year: 2019
  ident: ref_118
  article-title: Improving cancer immunotherapy through nanotechnology
  publication-title: Nat. Rev. Cancer
  doi: 10.1038/s41568-019-0186-9
  contributor:
    fullname: Goldberg
– volume: 179
  start-page: 112989
  year: 2020
  ident: ref_20
  article-title: Electrochemical genosensor based on carbon nanotube/amine-ionic liquid functionalized reduced graphene oxide nanoplatform for detection of human papillomavirus (HPV16)-related head and neck cancer
  publication-title: J. Pharm. Biomed. Anal.
  doi: 10.1016/j.jpba.2019.112989
  contributor:
    fullname: Farzin
– volume: 10
  start-page: 15350
  year: 2018
  ident: ref_68
  article-title: Influence of particle size and shape on their margination and wall-adhesion: Implications in drug delivery vehicle design across nano-to-micro scale
  publication-title: Nanoscale
  doi: 10.1039/C8NR04042G
  contributor:
    fullname: Cooley
– volume: 4
  start-page: 4371
  year: 2010
  ident: ref_76
  article-title: Biofunctionalized Phospholipid-Capped Mesoporous Silica Nanoshuttles for Targeted Drug Delivery: Improved Water Suspensibility and Decreased Nonspecific Protein Binding
  publication-title: ACS Nano
  doi: 10.1021/nn901376h
  contributor:
    fullname: Wang
– volume: 6
  start-page: eaaz4462
  year: 2020
  ident: ref_130
  article-title: The pore size of mesoporous silica nanoparticles regulates their antigen delivery efficiency
  publication-title: Sci Adv.
  doi: 10.1126/sciadv.aaz4462
  contributor:
    fullname: Hong
– volume: 187–188
  start-page: 109
  year: 2001
  ident: ref_39
  article-title: MCM-41, MCM-48 and related mesoporous adsorbents: Their synthesis and characterization
  publication-title: Colloids Surf. A Physiochem. Eng. Asp.
  doi: 10.1016/S0927-7757(01)00638-0
  contributor:
    fullname: Kumar
– volume: 9
  start-page: 2685
  year: 1997
  ident: ref_36
  article-title: Synthesis of MCM-48 Using Mixed Cationic−Anionic Surfactants as Templates
  publication-title: Chem. Mater.
  doi: 10.1021/cm9703942
  contributor:
    fullname: Chen
– volume: 309
  start-page: 94
  year: 2019
  ident: ref_69
  article-title: Shape effect in active targeting of nanoparticles to inflamed cerebral endothelium under static and flow conditions
  publication-title: J. Control. Release
  doi: 10.1016/j.jconrel.2019.07.026
  contributor:
    fullname: Brown
– volume: 3
  start-page: 961
  year: 2010
  ident: ref_86
  article-title: Cell-penetrating peptides—Mechanisms of cellular uptake and generation of delivery systems
  publication-title: Pharmaceuticals
  doi: 10.3390/ph3040961
  contributor:
    fullname: Trabulo
– volume: 63
  start-page: 988
  year: 1990
  ident: ref_30
  article-title: The Preparation of Alkyltrimethylammonium–Kanemite Complexes and Their Conversion to Microporous Materials
  publication-title: Bull. Chem. Soc. Jpn.
  doi: 10.1246/bcsj.63.988
  contributor:
    fullname: Yanagisawa
– volume: 284
  start-page: 171
  year: 2018
  ident: ref_73
  article-title: A minimal physiologically based pharmacokinetic model that predicts anti-PEG IgG-mediated clearance of PEGylated drugs in human and mouse
  publication-title: J. Control. Release
  doi: 10.1016/j.jconrel.2018.06.002
  contributor:
    fullname: McSweeney
– volume: 9
  start-page: 3138
  year: 2013
  ident: ref_146
  article-title: Mesoporous silica nanoparticles act as a self-adjuvant for ovalbumin model antigen in mice
  publication-title: Small
  doi: 10.1002/smll.201300012
  contributor:
    fullname: Mahony
– volume: 7
  start-page: 3276
  year: 2017
  ident: ref_140
  article-title: Biodegradable Hollow Mesoporous Silica Nanoparticles for Regulating Tumor Microenvironment and Enhancing Antitumor Efficiency
  publication-title: Theranostics
  doi: 10.7150/thno.19987
  contributor:
    fullname: Kong
– volume: 4
  start-page: 82
  year: 2013
  ident: ref_148
  article-title: Costimulatory molecules on immunogenic versus tolerogenic human dendritic cells
  publication-title: Front. Immunol.
  doi: 10.3389/fimmu.2013.00082
  contributor:
    fullname: Hubo
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SubjectTerms Antigen (tumor-associated)
Antigen-presenting cells
Antigens
Biocompatibility
Biodistribution
Cancer
Cancer immunotherapy
Cancer vaccines
Cancer Vaccines - immunology
Cancer Vaccines - therapeutic use
Chemotherapy
drug delivery
Drug delivery systems
Humans
Immune checkpoint
Immune response
Immune system
Immunosuppression
Immunotherapy
Laboratories
Lymphocytes
Lymphocytes T
mesoporous silica nanoparticles
Morphology
nanomaterial
Nanomaterials
Nanoparticles
Nanotechnology
Neoplasms - drug therapy
Particle size
Pore size
Porosity
Review
Silica
Silicon Dioxide
Surfactants
Tumors
Vaccines
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Title Recent Advances of Mesoporous Silica as a Platform for Cancer Immunotherapy
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Volume 12
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