Inhibition of the G9a/GLP histone methyltransferase complex modulates anxiety-related behavior in mice

• Published in: Acta pharmacologica Sinica Vol. 39; no. 5; pp. 866 - 874
• Main Authors: Wang, Dong-yao, Kosowan, Joel, Samsom, James, Leung, Laura, Zhang, Kai-lai, Li, Ying-xiang, Xiong, Yan, Jin, Jian, Petronis, Arturas, Oh, Gabriel, Wong, Albert H C
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.05.2018; Nature Publishing Group
• Subjects: Amitriptyline; Animals; Anti-Anxiety Agents - therapeutic use; Anxiety; Behavior; Biomedical and Life Sciences; Biomedicine; Developmental stages; Diazepam - therapeutic use; Dose-Response Relationship, Drug; Drug development; Embryos; Epigenesis, Genetic; Epigenetics; Female; Gene regulation; Histone H3; Histone methyltransferase; Histone-Lysine N-Methyltransferase - antagonists & inhibitors; Histones - genetics; Histones - metabolism; Imipramine; Immunology; Indoles - therapeutic use; Internal Medicine; Intrauterine exposure; Lysine; Male; Medical Microbiology; Mental depression; Mental disorders; Methylation; Mice, Inbred C57BL; Mood; Paroxetine; Pharmacology/Toxicology; Protein Processing, Post-Translational; Quinazolines - therapeutic use; Schizophrenia; Social behavior; Spiro Compounds - therapeutic use; Vaccine; Venlafaxine Hydrochloride - therapeutic use; anxiety; histone methyltransferase; G9a/GLP; depression; UNC0642; A-366; epigenetics

Epigenetic gene-regulation abnormalities have been implicated in various neuropsychiatric disorders including schizophrenia and depression, as well as in the regulation of mood and anxiety. In addition, epigenetic mechanisms are involved in the actions of psychiatric drugs. Current anxiolytic drugs...