Inhibition of the G9a/GLP histone methyltransferase complex modulates anxiety-related behavior in mice - Wang, Dong-yao; Kosowan, Joel; Samsom, James; Leung, Laura; Zhang, Kai-lai; Li, Ying-xiang; Xiong, Yan; Jin, Jian; Petronis, Arturas; Oh, Gabriel; Wong, Albert H C (Acta pharmacologica Sinica, 2018)
Keywords: Amitriptyline; Animals; Anti-Anxiety Agents - therapeutic use; Anxiety; Behavior; Biomedical and Life Sciences; Biomedicine; Developmental stages; Diazepam - therapeutic use; Dose-Response Relationship, Drug; Drug development; Embryos; Epigenesis, Genetic; Epigenetics; Female; Gene regulation; Histone H3; Histone methyltransferase; Histone-Lysine N-Methyltransferase - antagonists & inhibitors; Histones - genetics; Histones - metabolism; Imipramine; Immunology; Indoles - therapeutic use; Internal Medicine; Intrauterine exposure; Lysine; Male; Medical Microbiology; Mental depression; Mental disorders; Methylation; Mice, Inbred C57BL; Mood; Paroxetine; Pharmacology/Toxicology; Protein Processing, Post-Translational; Quinazolines - therapeutic use; Schizophrenia; Social behavior; Spiro Compounds - therapeutic use; Vaccine; Venlafaxine Hydrochloride - therapeutic use; anxiety; histone methyltransferase; G9a/GLP; depression; UNC0642; A-366; epigenetics