Exosomal and Non-Exosomal MicroRNAs: New Kids on the Block for Cancer Therapy

• Published in: International journal of molecular sciences Vol. 23; no. 9; p. 4493
• Main Authors: Syed, Shahzad Nawaz, Brüne, Bernhard
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 19.04.2022; MDPI
• Subjects: Antitumor activity; Breast cancer; Cancer; Cancer therapies; Communication; exosome; Exosomes - genetics; Extracellular vesicles; Gene expression; Gene Expression Regulation, Neoplastic; Gene regulation; Genomes; Humans; Hypoxia; Liposarcoma; Lymphocytes; Macromolecules; macrophage; Melanoma; microRNA; MicroRNAs; MicroRNAs - genetics; MicroRNAs - therapeutic use; miRNA; Neoplasms - genetics; Neoplasms - therapy; Post-transcription; Prospective Studies; Proteins; Review; RNA therapeutics; Severe acute respiratory syndrome coronavirus 2; Stroma; Therapeutic targets; Tumor microenvironment; Tumor Microenvironment - genetics; Tumors; Vaccines; breast cancer; macrophage; microRNA; cancer; RNA therapeutics; exosome

MicroRNAs have been projected as promising tools for diagnostic and prognostic purposes in cancer. More recently, they have been highlighted as RNA therapeutic targets for cancer therapy. Though miRs perform a generic function of post-transcriptional gene regulation, their utility in RNA therapeutic...