Application of physiologically based pharmacokinetic modeling for sertraline dosing recommendations in pregnancy

• Published in: NPJ systems biology and applications Vol. 6; no. 1; p. 36
• Main Authors: George, Blessy, Lumen, Annie, Nguyen, Christine, Wesley, Barbara, Wang, Jian, Beitz, Julie, Crentsil, Victor
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 06.11.2020; Nature Publishing Group; Springer Nature
• Subjects: 60 APPLIED LIFE SCIENCES; 631/114/794; 631/1647/794; Antidepressants; Bioinformatics; Biomedical and Life Sciences; Computational Biology/Bioinformatics; Computer Appl. in Life Sciences; Dosage; Drug dosages; Fetuses; Gestational age; Life Sciences; Metabolism; Pharmacokinetics; Physicochemical properties; Physiology; Placenta; Pregnancy; Sertraline; software; Systems Biology

Pregnancy is a period of significant change that impacts physiological and metabolic status leading to alterations in the disposition of drugs. Uncertainty in drug dosing in pregnancy can lead to suboptimal therapy, which can contribute to disease exacerbation. A few studies show there are increased...