Enterovirus-Associated Hand-Foot and Mouth Disease and Neurological Complications in Japan and the Rest of the World

• Published in: International journal of molecular sciences Vol. 20; no. 20; p. 5201
• Main Authors: Gonzalez, Gabriel, Carr, Michael J., Kobayashi, Masaaki, Hanaoka, Nozomu, Fujimoto, Tsuguto
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 20.10.2019; MDPI
• Subjects: Developed Countries; Developing Countries; Encephalitis; Enterovirus - isolation & purification; Enterovirus Infections - complications; Enterovirus Infections - virology; Epidemics; Feces; Gastroenteritis; Hand, Foot and Mouth Disease - epidemiology; Hand, Foot and Mouth Disease - virology; Humans; Incidence; Infections; Infectious diseases; Japan - epidemiology; Laboratories; Lymphatic system; Mouth; Nervous System Diseases - epidemiology; Nervous System Diseases - virology; Paralysis; Pathogens; Proteins; Review; Viral infections; Viruses; Japan; North America; hand-foot and mouth disease; molecular characterization; enterovirus A71; encephalitis; central nervous system complications

Enteroviruses (EVs) are responsible for extremely large-scale, periodic epidemics in pediatric cohorts, particularly in East and Southeast Asia. Clinical presentation includes a diverse disease spectrum, including hand-foot and mouth disease (HFMD), aseptic meningitis, encephalitis, acute flaccid pa...