Manufacturability and functionality assessment of different formats of T-cell engaging bispecific antibodies

• Published in: mAbs Vol. 15; no. 1; p. 2231129
• Main Authors: Loh, Han Ping, Mahfut, Farouq Bin, Chen, Serene W, Huang, Yuhan, Huo, Jianxin, Zhang, Wei, Lam, Kong Peng, Xu, Shengli, Yang, Yuansheng
• Format: Journal Article
• Language: English
• Published: United States Taylor & Francis 2023; Taylor & Francis Group
• Subjects: Antibodies, Bispecific; avidity; bispecific antibody; CHO cell; functionality; Immunoglobulin Fab Fragments; Immunoglobulin G; manufacturability; Single-Chain Antibodies; T-Lymphocytes; targeted integration; avidity; CHO cell; bispecific antibody; targeted integration; thermal stability; functionality; manufacturability

T-cell-engaging bispecific antibodies (T-bsAbs) are promising immunotherapies for cancer treatment due to their capability of redirecting T-cells toward destroying tumor cells. Numerous T-bsAb formats have been developed, each with advantages and disadvantages in terms of developability, immunogenic...