Mechanisms of Antidepressant Response to Electroconvulsive Therapy Studied With Perfusion Magnetic Resonance Imaging

• Published in: Biological psychiatry (1969) Vol. 85; no. 6; pp. 466 - 476
• Main Authors: Leaver, Amber M., Vasavada, Megha, Joshi, Shantanu H., Wade, Benjamin, Woods, Roger P., Espinoza, Randall, Narr, Katherine L.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 15.03.2019
• Subjects: Adult; Brain - blood supply; Cerebral blood flow; Depression; Depression - physiopathology; Depression - therapy; Electroconvulsive Therapy; Female; fMRI; Functional Neuroimaging; Hippocampus; Humans; Magnetic Resonance Imaging; Male; Psychiatric/Mental Health; Seizure; Time Factors; Young Adult; fMRI; Depression; Seizure; Electroconvulsive therapy; Cerebral blood flow; Hippocampus
• ISSN: 0006-3223; 1873-2402; 1873-2402
• DOI: 10.1016/j.biopsych.2018.09.021

Converging evidence suggests that electroconvulsive therapy (ECT) induces neuroplasticity in patients with severe depression, though how this relates to antidepressant response is less clear. Arterial spin-labeled functional magnetic resonance imaging tracks absolute changes in cerebral blood flow (CBF) linked with brain function and offers a potentially powerful tool when observing neurofunctional plasticity with functional magnetic resonance imaging. Using arterial spin-labeled functional magnetic resonance imaging, we measured global and regional CBF associated with clinically prescribed ECT and therapeutic response in patients (n = 57, 30 female) before ECT, after two treatments, after completing an ECT treatment “index” (∼4 weeks), and after long-term follow-up (6 months). Age- and sex-matched control subjects were also scanned twice (n = 36, 19 female), ∼4 weeks apart. Patients with lower baseline global CBF were more likely to respond to ECT. Regional CBF increased in the right anterior hippocampus in all patients irrespective of clinical outcome, both after 2 treatments and after ECT index. However, hippocampal CBF increases postindex were more pronounced in nonresponders. ECT responders exhibited CBF increases in the dorsomedial thalamus and motor cortex near the vertex ECT electrode, as well as decreased CBF within lateral frontoparietal regions. ECT induces functional neuroplasticity in the hippocampus, which could represent functional precursors of ECT-induced increases in hippocampal volume reported previously. However, excessive functional neuroplasticity within the hippocampus may not be conducive to positive clinical outcome. Instead, our results suggest that although hippocampal plasticity may contribute to antidepressant response in ECT, balanced plasticity in regions relevant to seizure physiology including thalamocortical networks may also play a critical role.