An Overview of the Dry Eye Disease in Sjögren's Syndrome Using Our Current Molecular Understanding

Sjögren's syndrome is a chronic and insidious auto-immune disease characterized by lymphocyte infiltration of exocrine glands. The patients typically present with ocular surface diseases related to dry eye and other systemic manifestations. However, due to the high prevalence of dry eye disease...

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Published inInternational journal of molecular sciences Vol. 24; no. 2; p. 1580
Main Authors Wu, Kevin Y, Kulbay, Merve, Tanasescu, Cristina, Jiao, Belinda, Nguyen, Bich H, Tran, Simon D
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 13.01.2023
MDPI
Subjects
Asymptomatic
Autoimmune diseases
basic research
Disease
DNA methylation
dry eye
Dry Eye Syndromes - complications
Dry Eye Syndromes - etiology
Exocrine glands
Eye diseases
Gene expression
Hepatitis
Horizon
Humans
immune pathway
Immunological diseases
Immunology
Literature reviews
Lymphocytes
Lymphoma
ocular surface
Pathogenesis
pathophysiology
Proteomics
Quality of Life
Review
Saliva
Sjogren's syndrome
Sjogren's Syndrome - complications
Sjogren's Syndrome - diagnosis
Sjögren syndrome
Tears
Viral infections
Viruses
proteomics
biomarkers
exosomes
ocular surface
pathophysiology
diagnosis
basic research
dry eye
Sjögren syndrome
immune pathway
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Abstract Sjögren's syndrome is a chronic and insidious auto-immune disease characterized by lymphocyte infiltration of exocrine glands. The patients typically present with ocular surface diseases related to dry eye and other systemic manifestations. However, due to the high prevalence of dry eye disease and the lack of objective and clinically reliable diagnostic tools, discriminating Sjögren's syndrome dry eye (SSDE) from non-Sjögren's syndrome dry eye (NSSDE) remains a challenge for clinicians. Diagnosing SS is important to improve the quality of life of patients through timely referral for systemic workups, as SS is associated with serious systemic complications such as lymphoma and other autoimmune diseases. The purpose of this article is to describe the current molecular understanding of Sjögren's syndrome and its implications for novel diagnostic modalities on the horizon. A literature review of the pre-clinical and clinical studies published between 2016 and 2022 was conducted. The SSDE pathophysiology and immunology pathways have become better understood in recent years. Novel diagnostic modalities, such as tear and saliva proteomics as well as exosomal biomarkers, provide hope on the horizon.
AbstractList Sjögren’s syndrome is a chronic and insidious auto-immune disease characterized by lymphocyte infiltration of exocrine glands. The patients typically present with ocular surface diseases related to dry eye and other systemic manifestations. However, due to the high prevalence of dry eye disease and the lack of objective and clinically reliable diagnostic tools, discriminating Sjögren’s syndrome dry eye (SSDE) from non-Sjögren’s syndrome dry eye (NSSDE) remains a challenge for clinicians. Diagnosing SS is important to improve the quality of life of patients through timely referral for systemic workups, as SS is associated with serious systemic complications such as lymphoma and other autoimmune diseases. The purpose of this article is to describe the current molecular understanding of Sjögren’s syndrome and its implications for novel diagnostic modalities on the horizon. A literature review of the pre-clinical and clinical studies published between 2016 and 2022 was conducted. The SSDE pathophysiology and immunology pathways have become better understood in recent years. Novel diagnostic modalities, such as tear and saliva proteomics as well as exosomal biomarkers, provide hope on the horizon.
Sjögren's syndrome is a chronic and insidious auto-immune disease characterized by lymphocyte infiltration of exocrine glands. The patients typically present with ocular surface diseases related to dry eye and other systemic manifestations. However, due to the high prevalence of dry eye disease and the lack of objective and clinically reliable diagnostic tools, discriminating Sjögren's syndrome dry eye (SSDE) from non-Sjögren's syndrome dry eye (NSSDE) remains a challenge for clinicians. Diagnosing SS is important to improve the quality of life of patients through timely referral for systemic workups, as SS is associated with serious systemic complications such as lymphoma and other autoimmune diseases. The purpose of this article is to describe the current molecular understanding of Sjögren's syndrome and its implications for novel diagnostic modalities on the horizon. A literature review of the pre-clinical and clinical studies published between 2016 and 2022 was conducted. The SSDE pathophysiology and immunology pathways have become better understood in recent years. Novel diagnostic modalities, such as tear and saliva proteomics as well as exosomal biomarkers, provide hope on the horizon.Sjögren's syndrome is a chronic and insidious auto-immune disease characterized by lymphocyte infiltration of exocrine glands. The patients typically present with ocular surface diseases related to dry eye and other systemic manifestations. However, due to the high prevalence of dry eye disease and the lack of objective and clinically reliable diagnostic tools, discriminating Sjögren's syndrome dry eye (SSDE) from non-Sjögren's syndrome dry eye (NSSDE) remains a challenge for clinicians. Diagnosing SS is important to improve the quality of life of patients through timely referral for systemic workups, as SS is associated with serious systemic complications such as lymphoma and other autoimmune diseases. The purpose of this article is to describe the current molecular understanding of Sjögren's syndrome and its implications for novel diagnostic modalities on the horizon. A literature review of the pre-clinical and clinical studies published between 2016 and 2022 was conducted. The SSDE pathophysiology and immunology pathways have become better understood in recent years. Novel diagnostic modalities, such as tear and saliva proteomics as well as exosomal biomarkers, provide hope on the horizon.
Author Nguyen, Bich H
Tanasescu, Cristina
Tran, Simon D
Wu, Kevin Y
Jiao, Belinda
Kulbay, Merve
AuthorAffiliation 5 CHU Sainte Justine Hospital, Montreal, QC H3T 1C5, Canada
6 Faculty of Dental Medicine and Oral Health Sciences, McGill University, Montreal, QC H3A 1G1, Canada
2 Faculty of Medicine, University of Montreal, Montreal, QC H3T 1J4, Canada
1 Department of Surgery, Division of Ophthalmology, University of Sherbrooke, Sherbrooke, QC J1G 2E8, Canada
3 School of Optometry, University of Montreal, Montreal, QC H3T 1P1, Canada
4 Department of Medicine, Division of Internal Medicine, University of Sherbrooke, Sherbrooke, QC J1G 2E8, Canada
AuthorAffiliation_xml – name: 3 School of Optometry, University of Montreal, Montreal, QC H3T 1P1, Canada
– name: 6 Faculty of Dental Medicine and Oral Health Sciences, McGill University, Montreal, QC H3A 1G1, Canada
– name: 1 Department of Surgery, Division of Ophthalmology, University of Sherbrooke, Sherbrooke, QC J1G 2E8, Canada
– name: 4 Department of Medicine, Division of Internal Medicine, University of Sherbrooke, Sherbrooke, QC J1G 2E8, Canada
– name: 2 Faculty of Medicine, University of Montreal, Montreal, QC H3T 1J4, Canada
– name: 5 CHU Sainte Justine Hospital, Montreal, QC H3T 1C5, Canada
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  fullname: Jiao, Belinda
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  orcidid: 0000-0001-5594-359X
  surname: Tran
  fullname: Tran, Simon D
  organization: Faculty of Dental Medicine and Oral Health Sciences, McGill University, Montreal, QC H3A 1G1, Canada
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Issue 2
Keywords proteomics
biomarkers
exosomes
ocular surface
pathophysiology
diagnosis
basic research
dry eye
Sjögren syndrome
immune pathway
Language English
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Snippet Sjögren's syndrome is a chronic and insidious auto-immune disease characterized by lymphocyte infiltration of exocrine glands. The patients typically present...
Sjögren’s syndrome is a chronic and insidious auto-immune disease characterized by lymphocyte infiltration of exocrine glands. The patients typically present...
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StartPage 1580
SubjectTerms Asymptomatic
Autoimmune diseases
basic research
Disease
DNA methylation
dry eye
Dry Eye Syndromes - complications
Dry Eye Syndromes - etiology
Exocrine glands
Eye diseases
Gene expression
Hepatitis
Horizon
Humans
immune pathway
Immunological diseases
Immunology
Literature reviews
Lymphocytes
Lymphoma
ocular surface
Pathogenesis
pathophysiology
Proteomics
Quality of Life
Review
Saliva
Sjogren's syndrome
Sjogren's Syndrome - complications
Sjogren's Syndrome - diagnosis
Sjögren syndrome
Tears
Viral infections
Viruses
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Title An Overview of the Dry Eye Disease in Sjögren's Syndrome Using Our Current Molecular Understanding
URI https://www.ncbi.nlm.nih.gov/pubmed/36675090
https://www.proquest.com/docview/2767228717
https://www.proquest.com/docview/2768225844
https://pubmed.ncbi.nlm.nih.gov/PMC9866656
https://doaj.org/article/fd53d16e98284060a5d7981207952287
Volume 24
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