Bone morphogenetic protein receptor complexes on the surface of live cells: a new oligomerization mode for serine/threonine kinase receptors

• Published in: Molecular biology of the cell Vol. 11; no. 3; pp. 1023 - 1035
• Main Authors: Gilboa, L, Nohe, A, Geissendörfer, T, Sebald, W, Henis, Y I, Knaus, P
• Format: Journal Article
• Language: English
• Published: United States The American Society for Cell Biology 01.03.2000
• Subjects: Animals; Biopolymers; Bone Morphogenetic Protein Receptors; Bone Morphogenetic Protein Receptors, Type I; Cells, Cultured; COS Cells; Fluorescent Antibody Technique; Humans; Ligands; Mice; Protein-Serine-Threonine Kinases - metabolism; Receptors, Cell Surface - metabolism; Receptors, Growth Factor - metabolism; Receptors, Transforming Growth Factor beta; Signal Transduction

The bone morphogenetic proteins (BMPs) play important roles in embryogenesis and normal cell growth. The BMP receptors belong to the family of serine/threonine kinase receptors, whose activation has been investigated intensively for the transforming growth factor-beta (TGF-beta) receptor subfamily....