Existence of SARS-CoV-2 Entry Molecules in the Oral Cavity

• Published in: International journal of molecular sciences Vol. 21; no. 17; p. 6000
• Main Authors: Sakaguchi, Wakako, Kubota, Nobuhisa, Shimizu, Tomoko, Saruta, Juri, Fuchida, Shinya, Kawata, Akira, Yamamoto, Yuko, Sugimoto, Masahiro, Yakeishi, Mayumi, Tsukinoki, Keiichi
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 20.08.2020; MDPI
• Subjects: Angiotensin-Converting Enzyme 2; Betacoronavirus - metabolism; Coronavirus Infections - metabolism; Coronaviruses; COVID-19; Cytoplasm; Furin - metabolism; Gingiva - metabolism; Humans; Mouth Mucosa - metabolism; Pandemics; Peptidyl-Dipeptidase A - metabolism; Pneumonia, Viral - metabolism; Proteins; Saliva - metabolism; SARS-CoV-2; Serine Endopeptidases - metabolism; Severe acute respiratory syndrome coronavirus 2; Spike Glycoprotein, Coronavirus - metabolism; Tongue - metabolism; Viral infections; Virus Internalization; saliva; ACE2; taste cell; SARS-CoV-2; oral cavity; TMPRSS2; tongue coating; furin

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) receptor, angiotensin-converting enzyme 2 (ACE2), transmembrane protease serine 2 (TMPRSS2), and furin, which promote entry of the virus into the host cell, have been identified as determinants of SARS-CoV-2 infection. Dorsal tongue an...