Transcriptional Regulation: Molecules, Involved Mechanisms, and Misregulation

Transcriptional regulation is a critical biological process that allows the cell or an organism to respond to a variety of intra- and extra-cellular signals, to define cell identity during development, to maintain it throughout its lifetime, and to coordinate cellular activity [...].

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Published inInternational journal of molecular sciences Vol. 20; no. 6; p. 1281
Main Authors Casamassimi, Amelia, Ciccodicola, Alfredo
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 14.03.2019
MDPI
Subjects
Autoimmune diseases
Autoimmunity
Biomarkers
Cancer
Cardiovascular diseases
Chromatin
Cofactors
Complexity
Deoxyribonucleic acid
DNA
DNA microarrays
Epigenetics
Gene expression
Gene regulation
Kinases
Medical research
Melanin
Metabolism
MicroRNAs
Mutation
n/a
Neurological diseases
Physiology
Proteins
Regulatory sequences
RNA polymerase
RNA-mediated interference
Splicing
Studies
Transcription factors
Tumors
Tyrosinase
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Abstract Transcriptional regulation is a critical biological process that allows the cell or an organism to respond to a variety of intra- and extra-cellular signals, to define cell identity during development, to maintain it throughout its lifetime, and to coordinate cellular activity [...].
AbstractList [...]various RNA maturation events, such as the splicing that occurs with transcription, constitute an additional level of complexity. [...]many syndromes and genetic and complex diseases—cancer, autoimmunity, neurological and developmental disorders, metabolic and cardiovascular diseases—can be caused by mutations/alterations in regulatory sequences, transcription factors, cofactors, chromatin regulators, ncRNAs, and other components of transcription apparatus [1,2,3,4]. [...]advances in our understanding of molecules and mechanisms involved in the transcriptional circuitry and apparatus lead to new insights into the pathogenetic mechanisms of various human diseases and disorders. [...]this study investigated the role of PpPax3 in melanin synthesis and used RNA interference to provide evidence that this function is exerted in this important marine species through the tyrosinase pathway [18]. [...]a small number of studies still utilize microarray as a useful approach.
Transcriptional regulation is a critical biological process that allows the cell or an organism to respond to a variety of intra- and extra-cellular signals, to define cell identity during development, to maintain it throughout its lifetime, and to coordinate cellular activity [...].
Author Ciccodicola, Alfredo
Casamassimi, Amelia
AuthorAffiliation 1 Department of Precision Medicine, University of Campania “Luigi Vanvitelli”, Via L. De Crecchio, 80138 Naples, Italy
2 Institute of Genetics and Biophysics “Adriano Buzzati Traverso”, CNR, 80131 Naples, Italy
3 Department of Science and Technology, University of Naples “Parthenope”, 80143 Naples, Italy
AuthorAffiliation_xml – name: 2 Institute of Genetics and Biophysics “Adriano Buzzati Traverso”, CNR, 80131 Naples, Italy
– name: 1 Department of Precision Medicine, University of Campania “Luigi Vanvitelli”, Via L. De Crecchio, 80138 Naples, Italy
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  orcidid: 0000-0002-6010-4261
  surname: Casamassimi
  fullname: Casamassimi, Amelia
  email: amelia.casamassimi@unicampania.it
  organization: Department of Precision Medicine, University of Campania "Luigi Vanvitelli", Via L. De Crecchio, 80138 Naples, Italy. amelia.casamassimi@unicampania.it
– sequence: 2
  givenname: Alfredo
  orcidid: 0000-0002-9924-1482
  surname: Ciccodicola
  fullname: Ciccodicola, Alfredo
  email: alfredo.ciccodicola@igb.cnr.it, alfredo.ciccodicola@igb.cnr.it
  organization: Department of Science and Technology, University of Naples "Parthenope", 80143 Naples, Italy. alfredo.ciccodicola@igb.cnr.it
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2019 by the authors. 2019
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Snippet Transcriptional regulation is a critical biological process that allows the cell or an organism to respond to a variety of intra- and extra-cellular signals,...
[...]various RNA maturation events, such as the splicing that occurs with transcription, constitute an additional level of complexity. [...]many syndromes and...
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StartPage 1281
SubjectTerms Autoimmune diseases
Autoimmunity
Biomarkers
Cancer
Cardiovascular diseases
Chromatin
Cofactors
Complexity
Deoxyribonucleic acid
DNA
DNA microarrays
Epigenetics
Gene expression
Gene regulation
Kinases
Medical research
Melanin
Metabolism
MicroRNAs
Mutation
n/a
Neurological diseases
Physiology
Proteins
Regulatory sequences
RNA polymerase
RNA-mediated interference
Splicing
Studies
Transcription factors
Tumors
Tyrosinase
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Title Transcriptional Regulation: Molecules, Involved Mechanisms, and Misregulation
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