METTL3 Regulates Osteoblast Differentiation and Inflammatory Response via Smad Signaling and MAPK Signaling

• Published in: International journal of molecular sciences Vol. 21; no. 1; p. 199
• Main Authors: Zhang, Yiwen, Gu, Xiaofei, Li, Di, Cai, Luhui, Xu, Qiong
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 27.12.2019; MDPI
• Subjects: 3T3 Cells; Adenosine - analogs & derivatives; Adenosine - metabolism; Animals; Cell Differentiation - physiology; Cell Line; Cytokines; Cytokines - metabolism; Down-Regulation - physiology; Gene expression; Homeostasis; Inflammation; Inflammation - metabolism; Kinases; Metabolism; Methyltransferases - metabolism; Mice; Mineralization; Mitogen-Activated Protein Kinases - metabolism; NF-kappa B - metabolism; Osteoblasts - metabolism; Osteogenesis - physiology; Phosphorylation; Phosphorylation - physiology; Proteins; RNA, Messenger - metabolism; Signal Transduction - physiology; Smad Proteins - metabolism; Up-Regulation - physiology; YTHDF2; osteoblast differentiation; METTL3; inflammatory response; Smad; MAPK; mRNA stability

Osteoblasts are crucial bone-building cells that maintain bone homeostasis, whereas inflammatory stimuli can inhibit osteogenesis and activate inflammatory response. N6-methyladenosine (m6A) is the most abundant mRNA modification in eukaryotes and plays important roles in multiple biological process...