Pathophysiology of Type 2 Diabetes Mellitus

• Published in: International journal of molecular sciences Vol. 21; no. 17; p. 6275
• Main Authors: Galicia-Garcia, Unai, Benito-Vicente, Asier, Jebari, Shifa, Larrea-Sebal, Asier, Siddiqi, Haziq, Uribe, Kepa B., Ostolaza, Helena, Martín, César
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 30.08.2020; MDPI
• Subjects: Animals; Blood Glucose - metabolism; Cardiovascular disease; Diabetes; Diabetes Mellitus, Type 2 - physiopathology; Epidemiology; Ethnicity; Family medical history; Genomes; Glucose; Homeostasis; Humans; Hyperglycemia; Inflammation; Insulin resistance; Insulin Secretion; Lifestyles; Metabolism; Mortality; Musculoskeletal system; Obesity; Pathogenesis; Pathophysiology; Physiology; Population; Review; Risk factors; cardiovascular disease; liver; adipocyte; muscle; pathophysiology; type 2 diabetes mellitus; β-cell; insulin resistance

Type 2 Diabetes Mellitus (T2DM), one of the most common metabolic disorders, is caused by a combination of two primary factors: defective insulin secretion by pancreatic β-cells and the inability of insulin-sensitive tissues to respond appropriately to insulin. Because insulin release and activity a...