Downregulation of MicroRNA-34c-5p facilitated neuroinflammation in drug-resistant epilepsy

• Published in: Brain research Vol. 1749; p. 147130
• Main Authors: Fu, Meng, Tao, Jie, Wang, Dongdong, Zhang, Zhiping, Wang, Xiaoli, Ji, Yonghua, Li, Zhiping
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 15.12.2020
• Subjects: Drug-resistant epilepsy; HMGB1; miR-34c-5p; Neurology; Neuron loss; Pediatric; Neuron loss; EEG; VPA; 3′-UTR; HMGB1; TLE; AEDs; SE; Drug-resistant epilepsy; DRE; KA; DSE; miR-34c-5p; Pediatric; drug-resistant epilepsy; antiepileptic drugs; temporal lobe epilepsy; drug-sensitive epilepsy; kainic acid; valproic acid; electroencephalogram; status epilepticus; 3′-untranslated regions

•MiR-34c-5p was down-regulated in drug-resistant epilepsy.•Down-regulation of miR-34c-5p led to increased expression of HMGB1 and IL-1β.•Aberrant expression of these molecules contributes to loss of hippocampal neurons.•MiR-34c-5p could be a potential therapeutic target for drug-resistant epilepsy....