Chronic treatment with fluoxetine up-regulates cellular BDNF mRNA expression in rat dopaminergic regions

• Published in: The international journal of neuropsychopharmacology Vol. 9; no. 3; pp. 307 - 317
• Main Authors: Molteni, Raffaella, Calabrese, Francesca, Bedogni, Francesco, Tongiorgi, Enrico, Fumagalli, Fabio, Racagni, Giorgio, Andrea Riva, Marco
• Format: Journal Article
• Language: English
• Published: Cambridge, UK Cambridge University Press 01.06.2006; Oxford University Press
• Subjects: Animals; Antidepressants; Brain - drug effects; Brain - metabolism; Brain-derived neurotrophic factor; Brain-Derived Neurotrophic Factor - biosynthesis; Brain-Derived Neurotrophic Factor - genetics; Cytoplasm - drug effects; Cytoplasm - metabolism; Dopamine - biosynthesis; Dopamine - genetics; Fluoxetine - administration & dosage; Gene Expression Regulation - drug effects; Gene Expression Regulation - physiology; Male; Rats; Rats, Sprague-Dawley; RNA, Messenger - biosynthesis; Up-Regulation - drug effects; Up-Regulation - physiology; dopaminergic system; in-situ hybridization; neurotrophin; Antidepressants; gene expression
• ISSN: 1461-1457; 1469-5111
• DOI: 10.1017/S1461145705005766

During the last few years several studies have highlighted the possibility that major depression can be characterized by a general reduction in brain plasticity and an increased vulnerability under challenging situations. Such dysfunction may be the consequence of reduced expression and function of...