Secreted Protein Acidic and Rich in Cysteine as a Molecular Physiological and Pathological Biomarker

• Published in: Biomolecules (Basel, Switzerland) Vol. 11; no. 11; p. 1689
• Main Authors: Ghanemi, Abdelaziz, Yoshioka, Mayumi, St-Amand, Jonny
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 13.11.2021; MDPI
• Subjects: Animal models; Animals; biomarker; Biomarkers; Biomarkers - metabolism; Body fat; Cardiovascular disease; Cysteine; Diabetes; expression; Gastrointestinal surgery; Gene expression; Humans; Inflammation; Inflammation - metabolism; Injuries; Laboratories; Liver cancer; Metabolism; Neoplasms - genetics; Neoplasms - metabolism; Neoplasms - pathology; Obesity; Opinion; Osteonectin; Osteonectin - genetics; Osteonectin - metabolism; Pathogenesis; pathology; Physiology; Proteins; secreted protein acidic and rich in cysteine; Serum levels; Stem cells; Weight control; Wound healing; Canada; Quebec Canada; physiology; expression; pathology; biomarker; secreted protein acidic and rich in cysteine
• ISSN: 2218-273X; 2218-273X
• DOI: 10.3390/biom11111689

Secreted protein acidic and rich in cysteine (SPARC) is expressed in diverse tissues and plays roles in various biological functions and processes. Increased serum levels of SPARC or its gene overexpression have been reported following numerous physiological and pathological changes including injuries, exercise, regeneration, obesity, cancer, and inflammation. Such expression pattern interrelation between these biological changes and the SPARC expression/secretion points to it as a biomarker. This property could lead to a variety of potential applications ranging from mechanistic studies and animal model validation to the clinical and therapeutic evaluation of both disease prognosis and pharmacological agents.