3D Printing in Solid Dosage Forms and Organ-on-Chip Applications

• Published in: Biosensors (Basel) Vol. 12; no. 4; p. 186
• Main Authors: Kassem, Tarek, Sarkar, Tanoy, Nguyen, Trieu, Saha, Dipongkor, Ahsan, Fakhrul
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 22.03.2022; MDPI
• Subjects: 3-D printers; 3D printing; Additive manufacturing; biosensing; Biosensors; CAD; Design; Dosage; Drug Compounding; Drug delivery systems; Drug dosages; Drug Evaluation, Preclinical; Drug screening; Drug therapy; FDA approval; Industrial production; Laser sintering; Model testing; New technology; organ-on-chip; personalized medicine; Pharmaceuticals; Polymerization; Polymers; Precision Medicine; Printing, Three-Dimensional; Rapid prototyping; Resins; Review; Screening; Solvents; spritam; Three dimensional models; Three dimensional printing; additive manufacturing; CAD; biosensing; 3D printing; organ-on-chip; personalized medicine; spritam
• DOI: 10.3390/bios12040186
• ISSN: 2079-6374

3D printing (3DP) can serve not only as an excellent platform for producing solid dosage forms tailored to individualized dosing regimens but can also be used as a tool for creating a suitable 3D model for drug screening, sensing, testing and organ-on-chip applications. Several new technologies have been developed to convert the conventional dosing regimen into personalized medicine for the past decade. With the approval of Spritam, the first pharmaceutical formulation produced by 3DP technology, this technology has caught the attention of pharmaceutical researchers worldwide. Consistent efforts are being made to improvise the process and mitigate other shortcomings such as restricted excipient choice, time constraints, industrial production constraints, and overall cost. The objective of this review is to provide an overview of the 3DP process, its types, types of material used, and the pros and cons of each technique in the application of not only creating solid dosage forms but also producing a 3D model for sensing, testing, and screening of the substances. The application of producing a model for the biosensing and screening of drugs besides the creation of the drug itself, offers a complete loop of application for 3DP in pharmaceutics.