Antibody response and antigen-specific gamma-interferon profiles of vaccinated and unvaccinated pregnant sheep experimentally infected with Brucella melitensis

• Published in: Veterinary microbiology Vol. 100; no. 3; pp. 219 - 231
• Main Authors: Durán-Ferrer, M, Léon, L, Nielsen, K, Caporale, V, Mendoza, J, Osuna, A, Perales, A, Smith, P, De-Frutos, C, Gómez-Martı́n, B, Lucas, A, Chico, R, Delgado, O.D, Escabias, J.C, Arrogante, L, Dı́az-Parra, R, Garrido, F
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier B.V 03.06.2004; Elsevier Science
• Subjects: Animals; antibodies; Antibodies, Bacterial - blood; Applied microbiology; Bacteriology; Biological and medical sciences; Brucella melitensis; Brucella melitensis - immunology; Brucella Vaccine - immunology; brucellosis; Brucellosis - immunology; Brucellosis - microbiology; Brucellosis - veterinary; cell-mediated immunity; complement fixation tests; Complement Fixation Tests - veterinary; diagnostic techniques; ELISA; enzyme-linked immunosorbent assay; Enzyme-Linked Immunosorbent Assay - veterinary; ewes; experimental design; Female; fluorescence; Fluorescence Polarization Immunoassay - veterinary; FPA; Fundamental and applied biological sciences. Psychology; Gamma-interferon test; Immune response; Immunocapture test; interferon-gamma; Interferon-gamma - blood; Interferon-gamma - immunology; Microbiology; Miscellaneous; parturition; pathogens; Pregnancy; Pregnancy Complications, Infectious - immunology; Pregnancy Complications, Infectious - microbiology; Pregnancy Complications, Infectious - veterinary; rams; Rose Bengal - metabolism; Sheep; Sheep Diseases - immunology; Sheep Diseases - microbiology; vaccination; Vaccination - veterinary; Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects); Immune response; Immunocapture test; Gamma-interferon test; FPA; Brucella melitensis; ELISA; Microbiology; Antibody; Cytokine; Vaccine; Antigen; Infection; Vertebrata; Mammalia; Brucellaceae; Bacteria; Sheep; Artiodactyla; Veterinary; ELISA assay; Ungulata; Gamma interferon
• ISSN: 0378-1135; 1873-2542
• DOI: 10.1016/j.vetmic.2004.02.008

It is well known that the immune response in sheep against Brucella melitensis is subject to individual variation, depending on diverse factors. It bears asking whether these factors (e.g. clinical disease, active infection, state of previous immunity), when affecting a group, can cause variation in...