The Effect of Resveratrol on Mitochondrial Function in Myoblasts of Patients with the Common m.3243A>G Mutation

• Published in: Biomolecules (Basel, Switzerland) Vol. 10; no. 8; p. 1103
• Main Authors: Motlagh Scholle, Leila, Schieffers, Helena, Al-Robaiy, Samiya, Thaele, Annemarie, Dehghani, Faramarz, Lehmann Urban, Diana, Zierz, Stephan
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 24.07.2020; MDPI
• Subjects: Adult; Aged; Antioxidants - pharmacology; Biosynthesis; Cell growth; Cells, Cultured; Cellular stress response; Deoxyribonucleic acid; Dietary restrictions; Disease; DNA; DNA, Mitochondrial - genetics; Electron transport; Evolution; Female; G mutation; Gene expression; Gene Expression - drug effects; Growth factors; Humans; Kinases; m.3243A> Male; Middle Aged; Mitochondria; Mitochondria - drug effects; Mitochondria - genetics; Mitochondria - metabolism; Mitochondrial DNA; Musculoskeletal system; Mutation; Myoblasts; Myoblasts - cytology; Myoblasts - drug effects; Myoblasts - metabolism; OXPHOS; Oxygen Consumption - drug effects; Phosphorylation; Respiration; Resveratrol; Resveratrol - pharmacology; SIRT1; SIRT1 protein; SIRT3; Sirtuin 1 - genetics; Sirtuin 1 - metabolism; Transfer RNA; Lithuania; United States > US; Germany; OXPHOS; m.3243A>G mutation; SIRT1; resveratrol; SIRT3

Mitochondrial function is essential for ATP-supply, especially in response to different cellular stressors. Increased mitochondrial biogenesis resulting from caloric restriction (CR) has been reported. Resveratrol (RSV) is believed to mimic the physiological effects of CR mainly via a sirtuin (SIRT)...