Design of Pectin-Based Hydrogel Microspheres for Targeted Pulmonary Delivery

• Published in: Gels Vol. 9; no. 9; p. 707
• Main Authors: Chai, Andy, Schmidt, Keagan, Brewster, Gregory, Xiong, Lu Shi Peng, Church, Benjamin, Wahl, Timothy, Sadabadi, Hamed, Kumpaty, Subha, Zhang, Wujie
• Format: Journal Article
• Language: English
• Published: Basel MDPI AG 01.09.2023; MDPI
• Subjects: Antibiotics; Biocompatibility; Chemical properties; Colloids; Design of experiments; Design optimization; Dosage and administration; drug delivery; Drug delivery systems; Drugs; Electric fields; electrospray; Flow stability; Gelatin; Health aspects; hydrogel; Hydrogels; Infections; Ions; Lungs; Mannitol; Microspheres; Natural polymers; Optimization; Pectin; Pharmaceutical research; Protective coatings; Respiration; Respiratory agents; Toxicity; Vehicles; Viscosity; United States

Pulmonary drug delivery via microspheres has gained growing interest as a noninvasive method for therapy. However, drug delivery through the lungs via inhalation faces great challenges due to the natural defense mechanisms of the respiratory tract, such as the removal or deactivation of drugs. This...