Allopregnanolone Alters the Gene Expression Profile of Human Glioblastoma Cells

• Published in: International journal of molecular sciences Vol. 19; no. 3; p. 864
• Main Authors: Zamora-Sánchez, Carmen J, Del Moral-Morales, Aylin, Hernández-Vega, Ana M, Hansberg-Pastor, Valeria, Salido-Guadarrama, Ivan, Rodríguez-Dorantes, Mauricio, Camacho-Arroyo, Ignacio
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 15.03.2018; MDPI
• Subjects: 5-alpha Reductase Inhibitors - pharmacology; Adenosine monophosphate; allopregnanolone; astrocytomas; Binding sites; Brain cancer; Brain tumors; CCAAT/enhancer-binding protein; Cell Line, Tumor; Cell proliferation; Cyclic AMP; Cytoskeleton; Cytoskeleton - genetics; Cytoskeleton - metabolism; Deoxyribonucleic acid; DNA; DNA biosynthesis; finasteride; Finasteride - pharmacology; Gene expression; Gene Expression Regulation, Neoplastic; Genes; Glioblastoma; Glioblastoma - genetics; Glioblastoma cells; glioblastomas; Humans; Kinases; Pregnanolone; Pregnanolone - pharmacology; Progesterone; progesterone metabolites; Promoter Regions, Genetic; Proteins; Steroid 5α-reductase; Steroid hormones; Steroids; Transcription factors; Transcription Factors - genetics; Transcription Factors - metabolism; Transcriptome - drug effects; Up-Regulation; allopregnanolone; finasteride; glioblastomas; astrocytomas; progesterone metabolites

Glioblastomas (GBM) are the most frequent and aggressive brain tumors. In these malignancies, progesterone (P4) promotes proliferation, migration, and invasion. The P4 metabolite allopregnanolone (3α-THP) similarly promotes cell proliferation in the U87 human GBM cell line. Here, we evaluated global...