FGF Family: From Drug Development to Clinical Application

• Published in: International journal of molecular sciences Vol. 19; no. 7; p. 1875
• Main Authors: Hui, Qi, Jin, Zi, Li, Xiaokun, Liu, Changxiao, Wang, Xiaojie
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 26.06.2018; MDPI
• Subjects: Amino acids; Angiogenesis; Animals; Bile; Binding sites; Cholesterol; Classification; Clinical Trials as Topic; Disease; Drug development; Drug Discovery; Endoplasmic reticulum; Fibroblast Growth Factors - metabolism; Fibroblasts; Glucose; Growth factors; Heparan sulfate; Humans; Laboratories; Ligands; Metabolism; Peer review; Peptides; Pharmaceuticals; Phylogenetics; Phylogeny; Proteins; Receptors, Fibroblast Growth Factor - metabolism; Review; Vitamin D; Wound healing; drug development; fibroblast growth factor receptor inhibitor; clinical application; wound healing; fibroblast growth factor; metabolic regulation

Fibroblast growth factor (FGF) belongs to a large family of growth factors. FGFs use paracrine or endocrine signaling to mediate a myriad of biological and pathophysiological process, including angiogenesis, wound healing, embryonic development, and metabolism regulation. FGF drugs for the treatment...