FGF Family: From Drug Development to Clinical Application
Fibroblast growth factor (FGF) belongs to a large family of growth factors. FGFs use paracrine or endocrine signaling to mediate a myriad of biological and pathophysiological process, including angiogenesis, wound healing, embryonic development, and metabolism regulation. FGF drugs for the treatment...
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| Published in | International journal of molecular sciences Vol. 19; no. 7; p. 1875 |
|---|---|
| Main Authors | , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Switzerland
MDPI AG
26.06.2018
MDPI |
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| Online Access | Get full text |
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| Abstract | Fibroblast growth factor (FGF) belongs to a large family of growth factors. FGFs use paracrine or endocrine signaling to mediate a myriad of biological and pathophysiological process, including angiogenesis, wound healing, embryonic development, and metabolism regulation. FGF drugs for the treatment of burn and ulcer wounds are now available. The recent discovery of the crucial roles of the endocrine-acting FGF19 subfamily in maintaining homeostasis of bile acid, glucose, and phosphate further extended the activity profile of this family. Here, the applications of recombinant FGFs for the treatment of wounds, diabetes, hypophosphatemia, the development of FGF receptor inhibitors as anti-neoplastic drugs, and the achievements of basic research and applications of FGFs in China are reviewed. |
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| AbstractList | Fibroblast growth factor (FGF) belongs to a large family of growth factors. FGFs use paracrine or endocrine signaling to mediate a myriad of biological and pathophysiological process, including angiogenesis, wound healing, embryonic development, and metabolism regulation. FGF drugs for the treatment of burn and ulcer wounds are now available. The recent discovery of the crucial roles of the endocrine-acting FGF19 subfamily in maintaining homeostasis of bile acid, glucose, and phosphate further extended the activity profile of this family. Here, the applications of recombinant FGFs for the treatment of wounds, diabetes, hypophosphatemia, the development of FGF receptor inhibitors as anti-neoplastic drugs, and the achievements of basic research and applications of FGFs in China are reviewed. Fibroblast growth factor (FGF) belongs to a large family of growth factors. FGFs use paracrine or endocrine signaling to mediate a myriad of biological and pathophysiological process, including angiogenesis, wound healing, embryonic development, and metabolism regulation. FGF drugs for the treatment of burn and ulcer wounds are now available. The recent discovery of the crucial roles of the endocrine-acting FGF19 subfamily in maintaining homeostasis of bile acid, glucose, and phosphate further extended the activity profile of this family. Here, the applications of recombinant FGFs for the treatment of wounds, diabetes, hypophosphatemia, the development of FGF receptor inhibitors as anti-neoplastic drugs, and the achievements of basic research and applications of FGFs in China are reviewed.Fibroblast growth factor (FGF) belongs to a large family of growth factors. FGFs use paracrine or endocrine signaling to mediate a myriad of biological and pathophysiological process, including angiogenesis, wound healing, embryonic development, and metabolism regulation. FGF drugs for the treatment of burn and ulcer wounds are now available. The recent discovery of the crucial roles of the endocrine-acting FGF19 subfamily in maintaining homeostasis of bile acid, glucose, and phosphate further extended the activity profile of this family. Here, the applications of recombinant FGFs for the treatment of wounds, diabetes, hypophosphatemia, the development of FGF receptor inhibitors as anti-neoplastic drugs, and the achievements of basic research and applications of FGFs in China are reviewed. |
| Author | Liu, Changxiao Hui, Qi Li, Xiaokun Wang, Xiaojie Jin, Zi |
| AuthorAffiliation | 3 State Key Laboratory of Drug Delivery Technology and Pharmacokinetics, Tianjin Institute of Pharmaceutical Research, 308 Anshan West Road, Tianjin 300193, China 1 School of Pharmacy, Wenzhou Medical University, Chashan University Park, Wenzhou 325035, China; huiqi1976@163.com (Q.H.); 18858818119@163.com (Z.J.); lixk1964@163.com (X.L.); liuchangxiao@163.com (C.L.) 2 Key Laboratory Biotechnology Pharmaceutical Engineering, Wenzhou Medical University, Chashan University Park, Wenzhou 325035, China |
| AuthorAffiliation_xml | – name: 1 School of Pharmacy, Wenzhou Medical University, Chashan University Park, Wenzhou 325035, China; huiqi1976@163.com (Q.H.); 18858818119@163.com (Z.J.); lixk1964@163.com (X.L.); liuchangxiao@163.com (C.L.) – name: 2 Key Laboratory Biotechnology Pharmaceutical Engineering, Wenzhou Medical University, Chashan University Park, Wenzhou 325035, China – name: 3 State Key Laboratory of Drug Delivery Technology and Pharmacokinetics, Tianjin Institute of Pharmaceutical Research, 308 Anshan West Road, Tianjin 300193, China |
| Author_xml | – sequence: 1 givenname: Qi surname: Hui fullname: Hui, Qi – sequence: 2 givenname: Zi surname: Jin fullname: Jin, Zi – sequence: 3 givenname: Xiaokun surname: Li fullname: Li, Xiaokun – sequence: 4 givenname: Changxiao surname: Liu fullname: Liu, Changxiao – sequence: 5 givenname: Xiaojie surname: Wang fullname: Wang, Xiaojie |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/29949887$$D View this record in MEDLINE/PubMed |
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| Keywords | drug development fibroblast growth factor receptor inhibitor clinical application wound healing fibroblast growth factor metabolic regulation |
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| SubjectTerms | Amino acids Angiogenesis Animals Bile Binding sites Cholesterol Classification Clinical Trials as Topic Disease Drug development Drug Discovery Endoplasmic reticulum Fibroblast Growth Factors - metabolism Fibroblasts Glucose Growth factors Heparan sulfate Humans Laboratories Ligands Metabolism Peer review Peptides Pharmaceuticals Phylogenetics Phylogeny Proteins Receptors, Fibroblast Growth Factor - metabolism Review Vitamin D Wound healing |
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| Title | FGF Family: From Drug Development to Clinical Application |
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