A Combination of Glutaminase Inhibitor 968 and PD-L1 Blockade Boosts the Immune Response against Ovarian Cancer

• Published in: Biomolecules (Basel, Switzerland) Vol. 11; no. 12; p. 1749
• Main Authors: Wang, Jing-Jing, Siu, Michelle Kwan-Yee, Jiang, Yu-Xin, Leung, Thomas Ho-Yin, Chan, David Wai, Wang, Huo-Gang, Ngan, Hextan Yuen-Sheung, Chan, Karen Kar-Loen
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 23.11.2021; MDPI
• Subjects: Animals; Annexin V; Antibodies; Antineoplastic Combined Chemotherapy Protocols - administration & dosage; Antineoplastic Combined Chemotherapy Protocols - pharmacology; Apoptosis; Benzophenanthridines - administration & dosage; Benzophenanthridines - pharmacology; Cancer therapies; CD3 antigen; CD4 antigen; CD8 antigen; Cell culture; Cell death; Cell Line, Tumor; Cell proliferation; Cell Proliferation - drug effects; Cell Survival - drug effects; Chemokines; Clinical outcomes; CXCL10 protein; CXCL11 protein; Drug Synergism; Female; Flow cytometry; Gene expression; Gene Expression Regulation, Neoplastic - drug effects; Glutaminase; Glutaminase - genetics; Glutamine; glutamine metabolism; Granzyme B; Humans; Immune checkpoint; Immune Checkpoint Inhibitors - administration & dosage; Immune Checkpoint Inhibitors - pharmacology; Immune response; Immune system; Immunotherapy; Isotypes; Kidneys; Lung cancer; Lymphocytes; Lymphocytes T; Medical prognosis; Metabolism; Metastases; Mice; Ovarian cancer; Ovarian Neoplasms - drug therapy; Ovarian Neoplasms - genetics; Ovarian Neoplasms - metabolism; PD-L1 protein; T cells; Treatment Outcome; Tumor cells; Tumor microenvironment; Tumor Microenvironment - drug effects; Tumorigenesis; Tumors; Xenograft Model Antitumor Assays; Xenografts; Hong Kong China; Canada; United States > US; glutamine metabolism; T cells; ovarian cancer; immunotherapy

Programmed cell death 1 ligand (PD-L1) blockade has been used therapeutically in the treatment of ovarian cancer, and potential combination treatment approaches are under investigation to improve the treatment response rate. The increased dependence on glutamine is widely observed in various type of...