Takeda G Protein–Coupled Receptor 5 Modulates Depression-like Behaviors via Hippocampal CA3 Pyramidal Neurons Afferent to Dorsolateral Septum

• Published in: Biological psychiatry (1969) Vol. 89; no. 11; pp. 1084 - 1095
• Main Authors: Wang, Hao, Tan, Yuan-Zhi, Mu, Rong-Hao, Tang, Su-Su, Liu, Xiao, Xing, Shu-Yun, Long, Yan, Yuan, Dan-Hua, Hong, Hao
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.06.2021
• Subjects: Animals; CA3 Region, Hippocampal - physiology; Depression; Dorsolateral septum; GABAergic neuron; Hippocampus; Mice; Psychiatric/Mental Health; Pyramidal Cells - physiology; Pyramidal neuron; Receptors, G-Protein-Coupled - physiology; Takeda G protein–coupled receptor 5; GABAergic neuron; Dorsolateral septum; Depression; Pyramidal neuron; Takeda G protein–coupled receptor 5; Hippocampus

Takeda G protein–coupled receptor 5 (TGR5) is recognized as a promising target for type 2 diabetes and metabolic syndrome; its expression has been demonstrated in the brain and is thought to be neuroprotective. Here, we hypothesize that dysfunction of central TGR5 may contribute to the pathogenesis...