Renin–Angiotensin System: An Important Player in the Pathogenesis of Acute Respiratory Distress Syndrome

• Published in: International journal of molecular sciences Vol. 21; no. 21; p. 8038
• Main Authors: Hrenak, Jaroslav, Simko, Fedor
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 28.10.2020; MDPI
• Subjects: ADAM17 Protein - metabolism; Angiotensin-Converting Enzyme 2; Animals; Avian flu; Bacterial infections; Betacoronavirus; Capillary Permeability - physiology; Chemokines; Coronavirus Infections - pathology; COVID-19; Cytokines; Enzymes; Gene expression; Humans; Hypertension; Inflammation; Inflammation - pathology; Lavage; Lung - immunology; Lung - pathology; Lungs; Mice; Mortality; Neutrophils; Pandemics; Pathogenesis; Peptides; Peptidyl-Dipeptidase A - metabolism; Permeability; Physiology; Pneumonia; Pneumonia, Viral - pathology; Pulmonary Edema - pathology; Rats; Renin-Angiotensin System - physiology; Respiratory distress syndrome; Respiratory system; Review; SARS-CoV-2; Severe Acute Respiratory Syndrome - pathology; Severe acute respiratory syndrome coronavirus 2; Tumor Necrosis Factor-alpha - metabolism; Tumor necrosis factor-TNF; Ventilators; COVID-19; ACE2; SARS-CoV-2; ARDS; renin–angiotensin system

Acute respiratory distress syndrome (ARDS) is characterized by massive inflammation, increased vascular permeability and pulmonary edema. Mortality due to ARDS remains very high and even in the case of survival, acute lung injury can lead to pulmonary fibrosis. The renin–angiotensin system (RAS) pla...