Omega-3 polyunsaturated fatty acids ameliorate neuroinflammation and mitigate ischemic stroke damage through interactions with astrocytes and microglia

• Published in: Journal of neuroimmunology Vol. 278; pp. 200 - 211
• Main Authors: Zendedel, Adib, Habib, Pardes, Dang, Jon, Lammerding, Leoni, Hoffmann, Stefanie, Beyer, Cordian, Slowik, Alexander
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 15.01.2015
• Subjects: Allergy and Immunology; Animals; Animals, Newborn; Anti-Inflammatory Agents - therapeutic use; Astrocytes - drug effects; Astrocytes - physiology; Astroglia; Brain Infarction - drug therapy; Brain Infarction - etiology; Cells, Cultured; Cerebral cortex; Cytokines - genetics; Cytokines - metabolism; Disease Models, Animal; Encephalitis - drug therapy; Encephalitis - etiology; Fatty Acids - blood; Fatty Acids, Omega-3 - therapeutic use; GAP-43 Protein - metabolism; Gene Expression Regulation - drug effects; Hypoxia; Infarction, Middle Cerebral Artery - complications; Male; Mice, Inbred BALB C; Microglia; Microglia - drug effects; Microglia - physiology; Movement Disorders - etiology; Neuroinflammation; Neurology; Neuron; Neurons - drug effects; Neurons - metabolism; PUFA n3; Rat; Rats; Rats, Wistar; Sensation Disorders - drug therapy; Sensation Disorders - etiology; Cerebral cortex; PUFA n3; Neuron; Astroglia; Rat; Hypoxia; Neuroinflammation; Microglia
• ISSN: 0165-5728; 1872-8421; 1872-8421
• DOI: 10.1016/j.jneuroim.2014.11.007

Omega-3 polyunsaturated fatty acids (PUFA n3) provide neuroprotection due to their anti-inflammatory and anti-apoptotic properties as well as their regulatory function on growth factors and neuronal plasticity. These qualities enable PUFA n3 to ameliorate stroke outcome and limit neuronal damage. Yo...