Electrochemical Detection of Electrolytes Using a Solid-State Ion-Selective Electrode of Single-Piece Type Membrane

This study aimed to develop simple electrochemical electrodes for the fast detection of chloride, sodium and potassium ions in human serum. A flat thin-film gold electrode was used as the detection electrode for chloride ions; a single-piece type membrane based solid-state ion-selective electrode (I...

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Published inBiosensors (Basel) Vol. 11; no. 4; p. 109
Main Authors Chen, Li-Da, Wang, Wei-Jhen, Wang, Gou-Jen
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 07.04.2021
MDPI
Subjects
Calcium
Calcium ions
Chloride
Chloride ions
Chlorides
cyclic voltammetry
Electrochemical analysis
electrochemical detection of electrolytes
Electrochemical Techniques
Electrochemistry
Electrodes
Electrolytes
Electrolytes - analysis
Gold
Humans
Ion-Selective Electrodes
Ions
Laboratories
Magnesium
Membranes
Molten salt electrolytes
Nanomaterials
Polyethylene terephthalate
Potassium
Scanning electron microscopy
Selectivity
Sodium
Solid electrolytes
Solid state
solid-state ion-selective electrode
Solvents
square-wave voltammetry
Tetracyanoquinodimethane
Thin films
Voltammetry
United States > US
Germany
solid-state ion-selective electrode
cyclic voltammetry
square-wave voltammetry
electrochemical detection of electrolytes
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Abstract This study aimed to develop simple electrochemical electrodes for the fast detection of chloride, sodium and potassium ions in human serum. A flat thin-film gold electrode was used as the detection electrode for chloride ions; a single-piece type membrane based solid-state ion-selective electrode (ISE), which was formed by covering a flat thin-film gold electrode with a mixture of 7,7,8,8-tetracyanoquinodimethane (TCNQ) and ion-selective membrane (ISM), was developed for sodium and potassium ions detection. Through cyclic voltammetry (CV) and square-wave voltammetry (SWV), the detection data can be obtained within two minutes. The linear detection ranges in the standard samples of chloride, sodium, and potassium ions were 25–200 mM, 50–200 mM, and 2–10 mM, with the average relative standard deviation (RSD) of 0.79%, 1.65%, and 0.47% and the average recovery rates of 101%, 100% and 96%, respectively. Interference experiments with Na+, K+, Cl−, Ca2+, and Mg2+ ions demonstrated that the proposed detection electrodes have good selectivity. Moreover, the proposed detection electrodes have characteristics such as the ability to be prepared under relatively simple process conditions, excellent detection sensitivity, and low RSD, and the detection linear range is suitable for the Cl−, Na+ and K+ concentrations in human serum.
AbstractList This study aimed to develop simple electrochemical electrodes for the fast detection of chloride, sodium and potassium ions in human serum. A flat thin-film gold electrode was used as the detection electrode for chloride ions; a single-piece type membrane based solid-state ion-selective electrode (ISE), which was formed by covering a flat thin-film gold electrode with a mixture of 7,7,8,8-tetracyanoquinodimethane (TCNQ) and ion-selective membrane (ISM), was developed for sodium and potassium ions detection. Through cyclic voltammetry (CV) and square-wave voltammetry (SWV), the detection data can be obtained within two minutes. The linear detection ranges in the standard samples of chloride, sodium, and potassium ions were 25–200 mM, 50–200 mM, and 2–10 mM, with the average relative standard deviation (RSD) of 0.79%, 1.65%, and 0.47% and the average recovery rates of 101%, 100% and 96%, respectively. Interference experiments with Na+, K+, Cl−, Ca2+, and Mg2+ ions demonstrated that the proposed detection electrodes have good selectivity. Moreover, the proposed detection electrodes have characteristics such as the ability to be prepared under relatively simple process conditions, excellent detection sensitivity, and low RSD, and the detection linear range is suitable for the Cl−, Na+ and K+ concentrations in human serum.
This study aimed to develop simple electrochemical electrodes for the fast detection of chloride, sodium and potassium ions in human serum. A flat thin-film gold electrode was used as the detection electrode for chloride ions; a single-piece type membrane based solid-state ion-selective electrode (ISE), which was formed by covering a flat thin-film gold electrode with a mixture of 7,7,8,8-tetracyanoquinodimethane (TCNQ) and ion-selective membrane (ISM), was developed for sodium and potassium ions detection. Through cyclic voltammetry (CV) and square-wave voltammetry (SWV), the detection data can be obtained within two minutes. The linear detection ranges in the standard samples of chloride, sodium, and potassium ions were 25–200 mM, 50–200 mM, and 2–10 mM, with the average relative standard deviation (RSD) of 0.79%, 1.65%, and 0.47% and the average recovery rates of 101%, 100% and 96%, respectively. Interference experiments with Na + , K + , Cl − , Ca 2+ , and Mg 2+ ions demonstrated that the proposed detection electrodes have good selectivity. Moreover, the proposed detection electrodes have characteristics such as the ability to be prepared under relatively simple process conditions, excellent detection sensitivity, and low RSD, and the detection linear range is suitable for the Cl − , Na + and K + concentrations in human serum.
This study aimed to develop simple electrochemical electrodes for the fast detection of chloride, sodium and potassium ions in human serum. A flat thin-film gold electrode was used as the detection electrode for chloride ions; a single-piece type membrane based solid-state ion-selective electrode (ISE), which was formed by covering a flat thin-film gold electrode with a mixture of 7,7,8,8-tetracyanoquinodimethane (TCNQ) and ion-selective membrane (ISM), was developed for sodium and potassium ions detection. Through cyclic voltammetry (CV) and square-wave voltammetry (SWV), the detection data can be obtained within two minutes. The linear detection ranges in the standard samples of chloride, sodium, and potassium ions were 25-200 mM, 50-200 mM, and 2-10 mM, with the average relative standard deviation (RSD) of 0.79%, 1.65%, and 0.47% and the average recovery rates of 101%, 100% and 96%, respectively. Interference experiments with Na , K , Cl , Ca , and Mg ions demonstrated that the proposed detection electrodes have good selectivity. Moreover, the proposed detection electrodes have characteristics such as the ability to be prepared under relatively simple process conditions, excellent detection sensitivity, and low RSD, and the detection linear range is suitable for the Cl , Na and K concentrations in human serum.
This study aimed to develop simple electrochemical electrodes for the fast detection of chloride, sodium and potassium ions in human serum. A flat thin-film gold electrode was used as the detection electrode for chloride ions; a single-piece type membrane based solid-state ion-selective electrode (ISE), which was formed by covering a flat thin-film gold electrode with a mixture of 7,7,8,8-tetracyanoquinodimethane (TCNQ) and ion-selective membrane (ISM), was developed for sodium and potassium ions detection. Through cyclic voltammetry (CV) and square-wave voltammetry (SWV), the detection data can be obtained within two minutes. The linear detection ranges in the standard samples of chloride, sodium, and potassium ions were 25-200 mM, 50-200 mM, and 2-10 mM, with the average relative standard deviation (RSD) of 0.79%, 1.65%, and 0.47% and the average recovery rates of 101%, 100% and 96%, respectively. Interference experiments with Na+, K+, Cl-, Ca2+, and Mg2+ ions demonstrated that the proposed detection electrodes have good selectivity. Moreover, the proposed detection electrodes have characteristics such as the ability to be prepared under relatively simple process conditions, excellent detection sensitivity, and low RSD, and the detection linear range is suitable for the Cl-, Na+ and K+ concentrations in human serum.This study aimed to develop simple electrochemical electrodes for the fast detection of chloride, sodium and potassium ions in human serum. A flat thin-film gold electrode was used as the detection electrode for chloride ions; a single-piece type membrane based solid-state ion-selective electrode (ISE), which was formed by covering a flat thin-film gold electrode with a mixture of 7,7,8,8-tetracyanoquinodimethane (TCNQ) and ion-selective membrane (ISM), was developed for sodium and potassium ions detection. Through cyclic voltammetry (CV) and square-wave voltammetry (SWV), the detection data can be obtained within two minutes. The linear detection ranges in the standard samples of chloride, sodium, and potassium ions were 25-200 mM, 50-200 mM, and 2-10 mM, with the average relative standard deviation (RSD) of 0.79%, 1.65%, and 0.47% and the average recovery rates of 101%, 100% and 96%, respectively. Interference experiments with Na+, K+, Cl-, Ca2+, and Mg2+ ions demonstrated that the proposed detection electrodes have good selectivity. Moreover, the proposed detection electrodes have characteristics such as the ability to be prepared under relatively simple process conditions, excellent detection sensitivity, and low RSD, and the detection linear range is suitable for the Cl-, Na+ and K+ concentrations in human serum.
Author Wang, Wei-Jhen
Chen, Li-Da
Wang, Gou-Jen
AuthorAffiliation 3 Regenerative Medicine and Cell Therapy Research Center, Kaohsiung Medical University, Kaohsiung 80708, Taiwan
1 Department of Mechanical Engineering, National Chung-Hsing University, Taichung 40227, Taiwan; 40332131@gm.nfu.edu.tw (L.-D.C.); freedom84528@gmail.com (W.-J.W.)
2 Graduate Institute of Biomedical Engineering, National Chung-Hsing University, Taichung 40227, Taiwan
AuthorAffiliation_xml – name: 3 Regenerative Medicine and Cell Therapy Research Center, Kaohsiung Medical University, Kaohsiung 80708, Taiwan
– name: 1 Department of Mechanical Engineering, National Chung-Hsing University, Taichung 40227, Taiwan; 40332131@gm.nfu.edu.tw (L.-D.C.); freedom84528@gmail.com (W.-J.W.)
– name: 2 Graduate Institute of Biomedical Engineering, National Chung-Hsing University, Taichung 40227, Taiwan
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BackLink https://www.ncbi.nlm.nih.gov/pubmed/33917075$$D View this record in MEDLINE/PubMed
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cyclic voltammetry
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electrochemical detection of electrolytes
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Snippet This study aimed to develop simple electrochemical electrodes for the fast detection of chloride, sodium and potassium ions in human serum. A flat thin-film...
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StartPage 109
SubjectTerms Calcium
Calcium ions
Chloride
Chloride ions
Chlorides
cyclic voltammetry
Electrochemical analysis
electrochemical detection of electrolytes
Electrochemical Techniques
Electrochemistry
Electrodes
Electrolytes
Electrolytes - analysis
Gold
Humans
Ion-Selective Electrodes
Ions
Laboratories
Magnesium
Membranes
Molten salt electrolytes
Nanomaterials
Polyethylene terephthalate
Potassium
Scanning electron microscopy
Selectivity
Sodium
Solid electrolytes
Solid state
solid-state ion-selective electrode
Solvents
square-wave voltammetry
Tetracyanoquinodimethane
Thin films
Voltammetry
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Title Electrochemical Detection of Electrolytes Using a Solid-State Ion-Selective Electrode of Single-Piece Type Membrane
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Volume 11
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