Evaluation of the Safety and Efficacy of Hydroxycitric Acid or Garcinia cambogia Extracts in Humans

• Published in: Critical reviews in food science and nutrition Vol. 52; no. 7; pp. 585 - 594
• Main Authors: Márquez, Fabiola, Babio, Nancy, Bulló, Mònica, Salas-Salvadó, J
• Format: Journal Article
• Language: English
• Published: Philadelphia, PA Taylor & Francis Group 01.07.2012; Taylor & Francis; Taylor & Francis Ltd
• Subjects: acetyl coenzyme A; adverse effects; Animals; antagonists & inhibitors; Anti-Obesity Agents; Anti-Obesity Agents - adverse effects; Anti-Obesity Agents - therapeutic use; ATP Citrate (pro-S)-Lyase; ATP Citrate (pro-S)-Lyase - antagonists & inhibitors; Biological and medical sciences; Biosynthesis; Body weight; chemistry; citrates; Citrates - adverse effects; Citrates - therapeutic use; Clinical trials; diet therapy; Dietary Supplements; Dietary Supplements - adverse effects; drug therapy; Dyslipidemias; Dyslipidemias - diet therapy; Dyslipidemias - drug therapy; Enzyme Inhibitors; Enzyme Inhibitors - adverse effects; Enzyme Inhibitors - therapeutic use; Extraction processes; Flowers & plants; Food industries; Fruit; Fruit - chemistry; Fundamental and applied biological sciences. Psychology; Garcinia cambogia; Garcinia cambogia - chemistry; Garcinia gummi-guta; General aspects; Humans; Hygiene and safety; Hypolipidemic Agents; Hypolipidemic Agents - adverse effects; Hypolipidemic Agents - therapeutic use; laboratory animals; lipid profile; Lipids; mortality; Overweight; Overweight - diet therapy; Overweight - drug therapy; Phytotherapy; Phytotherapy - adverse effects; Plant Extracts; Plant Extracts - adverse effects; Plant Extracts - therapeutic use; safety; Side effects; therapeutic use; Toxicity; Human; Evaluation; Acids; Body weight; lipid profile; Lipids; Extract; Safety; Garcinia cambogia; Profile

Several studies have shown that Garcinia cambogia plays an important role in the regulation of endogenous lipid biosynthesis. This effect is specially attributed to (-)-hydroxycitric acid (HCA) inhibiting the enzyme ATP-dependent citrate lyase, which catalyzes the cleavage of citrate to oxaloacetate...