Vasoprotective effects of neurocompensatory response to balloon injury during diabetes involve the improvement of Mas signaling by TGFβ1 activation

Abstract Balloon injury in diabetic rats triggers a sensory neurocompensatory response that restores the blood flow in contralateral carotid. These vasoprotective effects result from H2 O2 -mediated relaxation that counteracts AT1 -dependent contractile hyperreactivity. The most important mechanism...

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Published inVascular pharmacology Vol. 64; pp. 36 - 48
Main Authors Pernomian, Larissa, Gomes, Mayara S, Pernomian, Laena, Moreira, Rafael P, Corrêa, Fernando M.A, de Oliveira, Ana M
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.01.2015
Subjects
Angiotensin-(1–7)
Animals
Balloon Occlusion - adverse effects
Cardiovascular
Carotid Artery Injuries - metabolism
Carotid Artery Injuries - prevention & control
Carotid balloon injury
Diabetes Mellitus, Experimental - metabolism
Hydrogen peroxide
Male
Proto-Oncogene Proteins - biosynthesis
Rats
Rats, Wistar
Receptors, G-Protein-Coupled - biosynthesis
Signal Transduction - physiology
TGFβ1
Transforming Growth Factor beta1 - metabolism
Type I-diabetes
Vasodilation - physiology
Angiotensin-(1–7)
Hydrogen peroxide
Type I-diabetes
Carotid balloon injury
TGFβ 1
TGFβ1
TGFβ
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Abstract Abstract Balloon injury in diabetic rats triggers a sensory neurocompensatory response that restores the blood flow in contralateral carotid. These vasoprotective effects result from H2 O2 -mediated relaxation that counteracts AT1 -dependent contractile hyperreactivity. The most important mechanism from the renin–angiotensin-system in counteracting AT1 -mediated effects is that one is mediated by Mas receptors. Thus, we hypothesized that the vasoprotective effects of balloon neurocompensation in diabetic rats could result from the improvement of Mas signaling by H2 O2 -mediated sensory mechanisms. NK1 receptors are sensory components whose activation could lead to H2 O2 generation upon TGFβ1 release and ALK5-mediated Nox4 upregulation. Based on this, we aimed to investigate: (1) the role of the TGFβ1 /ALK5–Nox4–H2 O2 pathway on modulating Mas signaling in diabetic rat contralateral carotid; and (2) the contribution of Mas signaling in the control of local blood flow. Our results showed that balloon neurocompensation restored diabetic rat contralateral carotid flow by improving Mas signaling through NK1 -mediated TGFβ1 release. TGFβ1 /ALK5 activation enhanced Nox4 expression and Nox4-driven generation of H2 O2 . In turn, H2 O2 enhanced the local Mas -mediated relaxation. Since restenosis impairs diabetic rat ipsilateral carotid flow, the restoration of diabetic rat contralateral carotid flow may prevent further damages in cerebral irrigation by carotid pathways after angioplasty during diabetes.
AbstractList Balloon injury in diabetic rats triggers a sensory neurocompensatory response that restores the blood flow in contralateral carotid. These vasoprotective effects result from H2O2-mediated relaxation that counteracts AT1-dependent contractile hyperreactivity. The most important mechanism from the renin-angiotensin-system in counteracting AT1-mediated effects is that one is mediated by Mas receptors. Thus, we hypothesized that the vasoprotective effects of balloon neurocompensation in diabetic rats could result from the improvement of Mas signaling by H2O2-mediated sensory mechanisms. NK1 receptors are sensory components whose activation could lead to H2O2 generation upon TGFβ1 release and ALK5-mediated Nox4 upregulation. Based on this, we aimed to investigate: (1) the role of the TGFβ1/ALK5-Nox4-H2O2 pathway on modulating Mas signaling in diabetic rat contralateral carotid; and (2) the contribution of Mas signaling in the control of local blood flow. Our results showed that balloon neurocompensation restored diabetic rat contralateral carotid flow by improving Mas signaling through NK1-mediated TGFβ1 release. TGFβ1/ALK5 activation enhanced Nox4 expression and Nox4-driven generation of H2O2. In turn, H2O2 enhanced the local Mas-mediated relaxation. Since restenosis impairs diabetic rat ipsilateral carotid flow, the restoration of diabetic rat contralateral carotid flow may prevent further damages in cerebral irrigation by carotid pathways after angioplasty during diabetes.
Balloon injury in diabetic rats triggers a sensory neurocompensatory response that restores the blood flow in contralateral carotid. These vasoprotective effects result from H2O2-mediated relaxation that counteracts AT1-dependent contractile hyperreactivity. The most important mechanism from the renin–angiotensin-system in counteracting AT1-mediated effects is that one is mediated by Mas receptors. Thus, we hypothesized that the vasoprotective effects of balloon neurocompensation in diabetic rats could result from the improvement of Mas signaling by H2O2-mediated sensory mechanisms. NK1 receptors are sensory components whose activation could lead to H2O2 generation upon TGFβ1 release and ALK5-mediated Nox4 upregulation. Based on this, we aimed to investigate: (1) the role of the TGFβ1/ALK5–Nox4–H2O2 pathway on modulating Mas signaling in diabetic rat contralateral carotid; and (2) the contribution of Mas signaling in the control of local blood flow. Our results showed that balloon neurocompensation restored diabetic rat contralateral carotid flow by improving Mas signaling through NK1-mediated TGFβ1 release. TGFβ1/ALK5 activation enhanced Nox4 expression and Nox4-driven generation of H2O2. In turn, H2O2 enhanced the local Mas-mediated relaxation. Since restenosis impairs diabetic rat ipsilateral carotid flow, the restoration of diabetic rat contralateral carotid flow may prevent further damages in cerebral irrigation by carotid pathways after angioplasty during diabetes. Carotid balloon injury in type I-diabetic rats leads to restenosis at the ipsilateral artery, which impairs the local Mas-mediated relaxation and the local blood flow. At the same time, carotid balloon injury in type I-diabetic rats triggers a neurocompensatory response at the contralateral carotid, where SP leads to the endothelial release of TGFβ1 by activating endothelial NK1 receptors. In turn, TGFβ1 activates ALK5 receptors, enhancing the expression and activity of muscular Nox4, which generates high concentrations of H2O2. This ROS acts as a relaxant factor that enhances the local Mas-mediated relaxation. As a vasoprotective mechanism, the enhanced relaxation mediated by Mas receptors restores the local blood flow, previously impaired by diabetes. [Display omitted]
Abstract Balloon injury in diabetic rats triggers a sensory neurocompensatory response that restores the blood flow in contralateral carotid. These vasoprotective effects result from H2 O2 -mediated relaxation that counteracts AT1 -dependent contractile hyperreactivity. The most important mechanism from the renin–angiotensin-system in counteracting AT1 -mediated effects is that one is mediated by Mas receptors. Thus, we hypothesized that the vasoprotective effects of balloon neurocompensation in diabetic rats could result from the improvement of Mas signaling by H2 O2 -mediated sensory mechanisms. NK1 receptors are sensory components whose activation could lead to H2 O2 generation upon TGFβ1 release and ALK5-mediated Nox4 upregulation. Based on this, we aimed to investigate: (1) the role of the TGFβ1 /ALK5–Nox4–H2 O2 pathway on modulating Mas signaling in diabetic rat contralateral carotid; and (2) the contribution of Mas signaling in the control of local blood flow. Our results showed that balloon neurocompensation restored diabetic rat contralateral carotid flow by improving Mas signaling through NK1 -mediated TGFβ1 release. TGFβ1 /ALK5 activation enhanced Nox4 expression and Nox4-driven generation of H2 O2 . In turn, H2 O2 enhanced the local Mas -mediated relaxation. Since restenosis impairs diabetic rat ipsilateral carotid flow, the restoration of diabetic rat contralateral carotid flow may prevent further damages in cerebral irrigation by carotid pathways after angioplasty during diabetes.
Author Gomes, Mayara S
Corrêa, Fernando M.A
Moreira, Rafael P
de Oliveira, Ana M
Pernomian, Larissa
Pernomian, Laena
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Cites_doi 10.1161/CIRCRESAHA.110.221242
10.1016/0014-2999(94)90610-6
10.1161/01.RES.0000189301.10217.87
10.1016/j.phrs.2012.05.001
10.1161/01.ATV.0000225287.20034.2c
10.1038/sj.bjp.0705732
10.1152/ajplung.00269.2005
10.1093/alcalc/agt057
10.1021/jm0509905
10.1111/jphp.12105
10.1016/j.ejphar.2013.09.036
10.1016/j.bjps.2011.12.013
10.1016/j.ejphar.2013.02.053
10.1159/000159199
10.1016/j.freeradbiomed.2012.06.016
10.1155/2014/640329
10.1097/FJC.0b013e3181e571cd
10.1016/j.ejphar.2013.10.066
10.1089/ars.2011.4335
10.1016/j.ejphar.2011.12.036
10.1016/j.freeradbiomed.2008.08.013
10.1016/j.ejphar.2010.05.051
10.1161/CIRCULATIONAHA.112.132159
10.1038/hr.2009.74
10.1080/01926230701198469
10.1161/01.ATV.0000069236.27911.68
10.1161/01.ATV.0000152608.29351.8f
10.1111/j.1476-5381.2011.01275.x
10.1159/000049134
10.1152/ajpgi.2000.279.6.G1298
10.1038/sj.bjp.0705147
10.1002/cbf.1278
10.1083/jcb.102.4.1217
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Keywords Angiotensin-(1–7)
Hydrogen peroxide
Type I-diabetes
Carotid balloon injury
TGFβ 1
TGFβ1
TGFβ
Language English
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References Yousif, Benter, Hares, Canatan, Akhtar (bb0110) 2006; 24
Yousif, Dhaunsi, Makki, Qabazard, Akhtar, Benter (bb0120) 2012; 66
Milner, Crowe, Loesch, Anglin, Burnstock, McEwan (bb0050) 1997; 34
Scott-Burden, Vanhoutte (bb0165) 1994; 21
Silva, Pernomian, Grando, Amaral, Tanus-Santos, Bendhack (bb0155) 2013; 721
Clowes, Reidy, Clowes (bb0010) 1983; 49
Pernomian, Gomes, Restini, de Oliveira (bb0060) 2014; 2014
Pernomian, Gomes, Restini, Pupo, de Oliveira (bb0125) 2013; 65
Leite, Lacchini, Carnio, Queiroz, Tanus-Santos, de Oliveira (bb0135) 2013; 48
Gray, Marco, Okabe, Szyndralewiez, Heitz, Montezano (bb0145) 2013; 127
Iwai, Horiuchi (bb0065) 2009; 32
Stucchi, Shofer, Leeman, Materne, Beer, McClung (bb0115) 2000; 279
Pernomian, Gomes, Restini, Ramalho, Tirapelli, de Oliveira (bb0055) 2012; 678
Sato, Kawai-Kowase, Sato, Oyama, Kanai, Ohyama (bb0175) 2005; 25
Touyz, Yao, Schiffrin (bb0180) 2003; 23
Gao, Zhang, Janssen, Lee (bb0105) 2003; 138
Boudreau, Casterline, Rada, Korzeniowska, Leto (bb0095) 2012; 53
Pereira, Olivon, de Oliveira (bb0030) 2010; 642
Tong, Hou, Jourd'heuil, Weisbrod, Cohen (bb0090) 2010; 107
Dikalov, Dikalova, Bikineyeva, Schmidt, Harrison, Griendling (bb0100) 2008; 45
Assoain, Sporn (bb0160) 1986; 102
Gellibert, de Gouville, Woolven, Mathews, Nguyen, Bertho-Ruault (bb0150) 2006; 49
Accorsi-Mendonça, Corrêa, Paiva, de Souza, Laurindo, de Oliveira (bb0020) 2004; 142
Pernomian, Gomes, de Oliveira (bb0040) 2011; 163
Henderson, Ferguson, Terenghi (bb0170) 2012; 65
Pereira, Olivon, Pernomian, de Oliveira (bb0035) 2014; 723
Miller, Drummond, Schmidt, Sobey (bb0130) 2005; 97
Pernomian, Gomes, Corrêa, Restini, Ramalho, de Oliveira (bb0045) 2013; 708
Antonaccio, Normandin, Ferrer (bb0015) 1994; 256
Brown (bb0005) 2001; 11
de Godoy MA, Pernomian, de Oliveira, Rattan (bb0070) 2012; 2012
Pereira, Olivon, de Oliveira (bb0025) 2010; 56
Yaraee, Ghazanfari (bb0075) 2009; 8
Frazier, Thomas, Scicchitano, Mirabile, Boyce, Zimmerman (bb0085) 2007; 35
Martínez-Revelles, Avendaño, García-Redondo, Álvarez, Aguado, Pérez-Girón (bb0140) 2013; 18
Bobik (bb0080) 2006; 26
Sturrock, Cahill, Norman, Huecksteadt, Hill, Sanders (bb0185) 2006; 290
Pernomian (10.1016/j.vph.2015.01.001_bb0045) 2013; 708
Dikalov (10.1016/j.vph.2015.01.001_bb0100) 2008; 45
Gellibert (10.1016/j.vph.2015.01.001_bb0150) 2006; 49
Leite (10.1016/j.vph.2015.01.001_bb0135) 2013; 48
Martínez-Revelles (10.1016/j.vph.2015.01.001_bb0140) 2013; 18
Silva (10.1016/j.vph.2015.01.001_bb0155) 2013; 721
de Godoy MA (10.1016/j.vph.2015.01.001_bb0070) 2012; 2012
Bobik (10.1016/j.vph.2015.01.001_bb0080) 2006; 26
Henderson (10.1016/j.vph.2015.01.001_bb0170) 2012; 65
Iwai (10.1016/j.vph.2015.01.001_bb0065) 2009; 32
Stucchi (10.1016/j.vph.2015.01.001_bb0115) 2000; 279
Miller (10.1016/j.vph.2015.01.001_bb0130) 2005; 97
Frazier (10.1016/j.vph.2015.01.001_bb0085) 2007; 35
Pernomian (10.1016/j.vph.2015.01.001_bb0060) 2014; 2014
Gao (10.1016/j.vph.2015.01.001_bb0105) 2003; 138
Scott-Burden (10.1016/j.vph.2015.01.001_bb0165) 1994; 21
Yousif (10.1016/j.vph.2015.01.001_bb0120) 2012; 66
Pernomian (10.1016/j.vph.2015.01.001_bb0125) 2013; 65
Pereira (10.1016/j.vph.2015.01.001_bb0025) 2010; 56
Brown (10.1016/j.vph.2015.01.001_bb0005) 2001; 11
Touyz (10.1016/j.vph.2015.01.001_bb0180) 2003; 23
Pereira (10.1016/j.vph.2015.01.001_bb0030) 2010; 642
Yaraee (10.1016/j.vph.2015.01.001_bb0075) 2009; 8
Antonaccio (10.1016/j.vph.2015.01.001_bb0015) 1994; 256
Accorsi-Mendonça (10.1016/j.vph.2015.01.001_bb0020) 2004; 142
Sato (10.1016/j.vph.2015.01.001_bb0175) 2005; 25
Pernomian (10.1016/j.vph.2015.01.001_bb0055) 2012; 678
Tong (10.1016/j.vph.2015.01.001_bb0090) 2010; 107
Boudreau (10.1016/j.vph.2015.01.001_bb0095) 2012; 53
Gray (10.1016/j.vph.2015.01.001_bb0145) 2013; 127
Milner (10.1016/j.vph.2015.01.001_bb0050) 1997; 34
Pernomian (10.1016/j.vph.2015.01.001_bb0040) 2011; 163
Sturrock (10.1016/j.vph.2015.01.001_bb0185) 2006; 290
Pereira (10.1016/j.vph.2015.01.001_bb0035) 2014; 723
Yousif (10.1016/j.vph.2015.01.001_bb0110) 2006; 24
Clowes (10.1016/j.vph.2015.01.001_bb0010) 1983; 49
Assoain (10.1016/j.vph.2015.01.001_bb0160) 1986; 102
References_xml – volume: 35
  start-page: 284
  year: 2007
  end-page: 295
  ident: bb0085
  article-title: Inhibition of ALK5 signaling induces physeal dysplasia in rats
  publication-title: Toxicol Pathol
  contributor:
    fullname: Zimmerman
– volume: 34
  start-page: 31
  year: 1997
  end-page: 40
  ident: bb0050
  article-title: Neurocompensatory responses to balloon-catheter-induced injury of the rat carotid artery
  publication-title: J Vasc Res
  contributor:
    fullname: McEwan
– volume: 2012
  year: 2012
  ident: bb0070
  article-title: Biosynthetic pathways and the role of the MAS receptor in the effects of angiotensin-(1–7) in smooth muscle
  publication-title: Int J Hypertens
  contributor:
    fullname: Rattan
– volume: 678
  start-page: 15
  year: 2012
  end-page: 25
  ident: bb0055
  article-title: The role of reactive oxygen species in the modulation of the contraction induced by angiotensin II in carotid artery from diabetic rat
  publication-title: Eur J Pharmacol
  contributor:
    fullname: de Oliveira
– volume: 25
  start-page: 341
  year: 2005
  end-page: 347
  ident: bb0175
  article-title: c-Src and hydrogen peroxide mediate transforming growth factor-β1-induced smooth muscle cell — gene expression in 10T1/2 cells
  publication-title: Arterioscler Thromb Vasc Biol
  contributor:
    fullname: Ohyama
– volume: 127
  start-page: 1888
  year: 2013
  end-page: 1902
  ident: bb0145
  article-title: NADPH oxidase 1 plays a key role in diabetes mellitus-accelerated atherosclerosis
  publication-title: Circulation
  contributor:
    fullname: Montezano
– volume: 32
  start-page: 533
  year: 2009
  end-page: 536
  ident: bb0065
  article-title: Devil and angel in the renin–angiotensin system: ACE–angiotensin II–AT1 receptor axis vs. ACE2–angiotensin-(1–7)–Mas receptor axis
  publication-title: Hypertens Res
  contributor:
    fullname: Horiuchi
– volume: 66
  start-page: 269
  year: 2012
  end-page: 275
  ident: bb0120
  article-title: Characterization of angiotensin-(1–7) effects on the cardiovascular system in an experimental model of type-1 diabetes
  publication-title: Pharmacol Res
  contributor:
    fullname: Benter
– volume: 56
  start-page: 162
  year: 2010
  end-page: 170
  ident: bb0025
  article-title: An apparent paradox: attenuation of phenylephrine-mediated calcium mobilization and hyperreactivity to phenylephrine in contralateral carotid after balloon injury
  publication-title: J Cardiovasc Pharmacol
  contributor:
    fullname: de Oliveira
– volume: 290
  start-page: L661
  year: 2006
  end-page: L673
  ident: bb0185
  article-title: Transforming growth factor-β1 induces Nox4 NAD(P)H oxidase and reactive oxygen species-dependent proliferation in human pulmonary artery smooth muscle cells
  publication-title: Am J Physiol Lung Cell Mol Physiol
  contributor:
    fullname: Sanders
– volume: 8
  start-page: 19
  year: 2009
  end-page: 24
  ident: bb0075
  article-title: Substance P potentiates TGF-β1 production in lung epithelial cell lines
  publication-title: Iran J Allergy Asthma Immunol
  contributor:
    fullname: Ghazanfari
– volume: 18
  start-page: 51
  year: 2013
  end-page: 65
  ident: bb0140
  article-title: Reciprocal relationship between reactive oxygen species and cyclooxygenase-2 and vascular dysfunction in hypertension
  publication-title: Antioxid Redox Signal
  contributor:
    fullname: Pérez-Girón
– volume: 97
  start-page: 1055
  year: 2005
  end-page: 1062
  ident: bb0130
  article-title: NADPH oxidase activity and function are profoundly greater in cerebral versus systemic arteries
  publication-title: Circ Res
  contributor:
    fullname: Sobey
– volume: 138
  start-page: 1085
  year: 2003
  end-page: 1092
  ident: bb0105
  article-title: Mechanisms of hydrogen-peroxide-induced biphasic response in rat mesenteric artery
  publication-title: Br J Pharmacol
  contributor:
    fullname: Lee
– volume: 65
  start-page: 1337
  year: 2013
  end-page: 1346
  ident: bb0125
  article-title: Cross-talk with β2-adrenoceptors that mediates carotid relaxation
  publication-title: J Pharm Pharmacol
  contributor:
    fullname: de Oliveira
– volume: 142
  start-page: 79
  year: 2004
  end-page: 88
  ident: bb0020
  article-title: The balloon catheter induces an increase in contralateral carotid artery reactivity to angiotensin II and phenylephrine
  publication-title: Br J Pharmacol
  contributor:
    fullname: de Oliveira
– volume: 723
  start-page: 397
  year: 2014
  end-page: 404
  ident: bb0035
  article-title: Impairment of α1-adrenoceptor-mediated calcium influx in contralateral carotids following balloon injury: beneficial effects of superoxide anions
  publication-title: Eur J Pharmacol
  contributor:
    fullname: de Oliveira
– volume: 26
  start-page: 1712
  year: 2006
  end-page: 1720
  ident: bb0080
  article-title: Transforming growth factor-βs and vascular disorders
  publication-title: Arterioscler Thromb Vasc Biol
  contributor:
    fullname: Bobik
– volume: 23
  start-page: 981
  year: 2003
  end-page: 987
  ident: bb0180
  article-title: c-Src induces phosphorylation and translocation of p47phox: role in superoxide generation by angiotensin II in human vascular smooth muscle cells
  publication-title: Arterioscler Thromb Vasc Biol
  contributor:
    fullname: Schiffrin
– volume: 49
  start-page: 2210
  year: 2006
  end-page: 2221
  ident: bb0150
  article-title: Discovery of 4-{4-[3-(pyridin-2yl)-1H-pyrazol-4-yl]pyridin-2-yl}-N-(tetrahydro-2H-pyran-4-yl)benzamide (GW788388): a potent, selective, and orally active transforming growth factor-beta type I receptor inhibitor
  publication-title: J Med Chem
  contributor:
    fullname: Bertho-Ruault
– volume: 45
  start-page: 1340
  year: 2008
  end-page: 1351
  ident: bb0100
  article-title: Distinct roles of Nox1 and Nox4 in basal and angiotensin II-stimulated superoxide and hydrogen peroxide production
  publication-title: Free Radic Biol Med
  contributor:
    fullname: Griendling
– volume: 49
  start-page: 327
  year: 1983
  end-page: 333
  ident: bb0010
  article-title: Kinetics of cellular proliferation after arterial injury. I. Smooth muscle growth in the absence of endothelium
  publication-title: Lab Invest
  contributor:
    fullname: Clowes
– volume: 24
  start-page: 13
  year: 2006
  end-page: 22
  ident: bb0110
  article-title: Phosphoinositide-3-kinase meditated signaling contributes to development of diabetes-induced abnormal vascular reactivity of rat carotid artery
  publication-title: Cell Biochem Funct
  contributor:
    fullname: Akhtar
– volume: 256
  start-page: 17
  year: 1994
  end-page: 21
  ident: bb0015
  article-title: Reduced contractile function after balloon denudation of rat carotid arteries
  publication-title: Eur J Pharmacol
  contributor:
    fullname: Ferrer
– volume: 642
  start-page: 121
  year: 2010
  end-page: 127
  ident: bb0030
  article-title: Impaired calcium influx despite hyper-reactivity in contralateral carotid following balloon injury: eNOS involvement
  publication-title: Eur J Pharmacol
  contributor:
    fullname: de Oliveira
– volume: 163
  start-page: 770
  year: 2011
  end-page: 781
  ident: bb0040
  article-title: Balloon catheter injury abolishes phenylephrine-induced relaxation in the rat contralateral carotid
  publication-title: Br J Pharmacol
  contributor:
    fullname: de Oliveira
– volume: 48
  start-page: 657
  year: 2013
  end-page: 666
  ident: bb0135
  article-title: Ethanol consumption increases endothelin-1 expression and reactivity in the rat cavernosal smooth muscle
  publication-title: Alcohol Alcohol
  contributor:
    fullname: de Oliveira
– volume: 708
  start-page: 124
  year: 2013
  end-page: 138
  ident: bb0045
  article-title: Diabetes confers a vasoprotective role to the neurocompensatory response elicited by carotid balloon injury: consequences on contralateral carotid tone and blood flow
  publication-title: Eur J Pharmacol
  contributor:
    fullname: de Oliveira
– volume: 53
  start-page: 1489
  year: 2012
  end-page: 1499
  ident: bb0095
  article-title: Nox4 involvement in TGF-beta and SMAD3-driven induction of the epithelial-to-mesenchymal transition and migration of breast epithelial cells
  publication-title: Free Radic Biol Med
  contributor:
    fullname: Leto
– volume: 102
  start-page: 1217
  year: 1986
  end-page: 1223
  ident: bb0160
  article-title: Type β transforming growth factor in human platelets: release during platelet degranulation and action on vascular smooth muscle cells
  publication-title: J Cell Biol
  contributor:
    fullname: Sporn
– volume: 107
  start-page: 975
  year: 2010
  end-page: 983
  ident: bb0090
  article-title: Upregulation of Nox4 by TGFβ1 oxidizes SERCA and inhibits NO in arterial smooth muscle of the prediabetic Zucker rat
  publication-title: Circ Res
  contributor:
    fullname: Cohen
– volume: 279
  start-page: G1298
  year: 2000
  end-page: G1306
  ident: bb0115
  article-title: NK-1 antagonist reduces colonic inflammation and oxidative stress in dextran sulfate-induced colitis in rats
  publication-title: Am J Physiol Gastrointest Liver Physiol
  contributor:
    fullname: McClung
– volume: 2014
  year: 2014
  ident: bb0060
  article-title: Mas-mediated antioxidant effects restore the functionality of angiotensin converting enzyme 2–angiotensin-(1–7)–
  publication-title: Biomed Res Int
  contributor:
    fullname: de Oliveira
– volume: 65
  start-page: e80
  year: 2012
  end-page: e86
  ident: bb0170
  article-title: The reinnervation pattern of wounds and scars after treatment with transforming growth factor β isoforms
  publication-title: J Plast Reconstr Aesthet Surg
  contributor:
    fullname: Terenghi
– volume: 11
  start-page: 112
  year: 2001
  end-page: 118
  ident: bb0005
  article-title: Carotid angioplasty and stenting: are they therapeutic alternatives?
  publication-title: Cerebrovasc Dis
  contributor:
    fullname: Brown
– volume: 721
  start-page: 193
  year: 2013
  end-page: 200
  ident: bb0155
  article-title: Hydrogen peroxide modulates phenylephrine-induced contractile response in renal hypertensive rat aorta
  publication-title: Eur J Pharmacol
  contributor:
    fullname: Bendhack
– volume: 21
  start-page: 91
  year: 1994
  end-page: 97
  ident: bb0165
  article-title: Regulation of smooth muscle cell growth by endothelium-derived factors
  publication-title: Tex Heart Inst J
  contributor:
    fullname: Vanhoutte
– volume: 107
  start-page: 975
  year: 2010
  ident: 10.1016/j.vph.2015.01.001_bb0090
  article-title: Upregulation of Nox4 by TGFβ1 oxidizes SERCA and inhibits NO in arterial smooth muscle of the prediabetic Zucker rat
  publication-title: Circ Res
  doi: 10.1161/CIRCRESAHA.110.221242
  contributor:
    fullname: Tong
– volume: 256
  start-page: 17
  year: 1994
  ident: 10.1016/j.vph.2015.01.001_bb0015
  article-title: Reduced contractile function after balloon denudation of rat carotid arteries
  publication-title: Eur J Pharmacol
  doi: 10.1016/0014-2999(94)90610-6
  contributor:
    fullname: Antonaccio
– volume: 97
  start-page: 1055
  year: 2005
  ident: 10.1016/j.vph.2015.01.001_bb0130
  article-title: NADPH oxidase activity and function are profoundly greater in cerebral versus systemic arteries
  publication-title: Circ Res
  doi: 10.1161/01.RES.0000189301.10217.87
  contributor:
    fullname: Miller
– volume: 66
  start-page: 269
  year: 2012
  ident: 10.1016/j.vph.2015.01.001_bb0120
  article-title: Characterization of angiotensin-(1–7) effects on the cardiovascular system in an experimental model of type-1 diabetes
  publication-title: Pharmacol Res
  doi: 10.1016/j.phrs.2012.05.001
  contributor:
    fullname: Yousif
– volume: 26
  start-page: 1712
  year: 2006
  ident: 10.1016/j.vph.2015.01.001_bb0080
  article-title: Transforming growth factor-βs and vascular disorders
  publication-title: Arterioscler Thromb Vasc Biol
  doi: 10.1161/01.ATV.0000225287.20034.2c
  contributor:
    fullname: Bobik
– volume: 142
  start-page: 79
  year: 2004
  ident: 10.1016/j.vph.2015.01.001_bb0020
  article-title: The balloon catheter induces an increase in contralateral carotid artery reactivity to angiotensin II and phenylephrine
  publication-title: Br J Pharmacol
  doi: 10.1038/sj.bjp.0705732
  contributor:
    fullname: Accorsi-Mendonça
– volume: 290
  start-page: L661
  year: 2006
  ident: 10.1016/j.vph.2015.01.001_bb0185
  article-title: Transforming growth factor-β1 induces Nox4 NAD(P)H oxidase and reactive oxygen species-dependent proliferation in human pulmonary artery smooth muscle cells
  publication-title: Am J Physiol Lung Cell Mol Physiol
  doi: 10.1152/ajplung.00269.2005
  contributor:
    fullname: Sturrock
– volume: 48
  start-page: 657
  year: 2013
  ident: 10.1016/j.vph.2015.01.001_bb0135
  article-title: Ethanol consumption increases endothelin-1 expression and reactivity in the rat cavernosal smooth muscle
  publication-title: Alcohol Alcohol
  doi: 10.1093/alcalc/agt057
  contributor:
    fullname: Leite
– volume: 49
  start-page: 2210
  year: 2006
  ident: 10.1016/j.vph.2015.01.001_bb0150
  article-title: Discovery of 4-{4-[3-(pyridin-2yl)-1H-pyrazol-4-yl]pyridin-2-yl}-N-(tetrahydro-2H-pyran-4-yl)benzamide (GW788388): a potent, selective, and orally active transforming growth factor-beta type I receptor inhibitor
  publication-title: J Med Chem
  doi: 10.1021/jm0509905
  contributor:
    fullname: Gellibert
– volume: 21
  start-page: 91
  year: 1994
  ident: 10.1016/j.vph.2015.01.001_bb0165
  article-title: Regulation of smooth muscle cell growth by endothelium-derived factors
  publication-title: Tex Heart Inst J
  contributor:
    fullname: Scott-Burden
– volume: 65
  start-page: 1337
  year: 2013
  ident: 10.1016/j.vph.2015.01.001_bb0125
  article-title: Cross-talk with β2-adrenoceptors that mediates carotid relaxation
  publication-title: J Pharm Pharmacol
  doi: 10.1111/jphp.12105
  contributor:
    fullname: Pernomian
– volume: 721
  start-page: 193
  year: 2013
  ident: 10.1016/j.vph.2015.01.001_bb0155
  article-title: Hydrogen peroxide modulates phenylephrine-induced contractile response in renal hypertensive rat aorta
  publication-title: Eur J Pharmacol
  doi: 10.1016/j.ejphar.2013.09.036
  contributor:
    fullname: Silva
– volume: 65
  start-page: e80
  year: 2012
  ident: 10.1016/j.vph.2015.01.001_bb0170
  article-title: The reinnervation pattern of wounds and scars after treatment with transforming growth factor β isoforms
  publication-title: J Plast Reconstr Aesthet Surg
  doi: 10.1016/j.bjps.2011.12.013
  contributor:
    fullname: Henderson
– volume: 708
  start-page: 124
  year: 2013
  ident: 10.1016/j.vph.2015.01.001_bb0045
  article-title: Diabetes confers a vasoprotective role to the neurocompensatory response elicited by carotid balloon injury: consequences on contralateral carotid tone and blood flow
  publication-title: Eur J Pharmacol
  doi: 10.1016/j.ejphar.2013.02.053
  contributor:
    fullname: Pernomian
– volume: 34
  start-page: 31
  year: 1997
  ident: 10.1016/j.vph.2015.01.001_bb0050
  article-title: Neurocompensatory responses to balloon-catheter-induced injury of the rat carotid artery
  publication-title: J Vasc Res
  doi: 10.1159/000159199
  contributor:
    fullname: Milner
– volume: 53
  start-page: 1489
  year: 2012
  ident: 10.1016/j.vph.2015.01.001_bb0095
  article-title: Nox4 involvement in TGF-beta and SMAD3-driven induction of the epithelial-to-mesenchymal transition and migration of breast epithelial cells
  publication-title: Free Radic Biol Med
  doi: 10.1016/j.freeradbiomed.2012.06.016
  contributor:
    fullname: Boudreau
– volume: 2014
  year: 2014
  ident: 10.1016/j.vph.2015.01.001_bb0060
  article-title: Mas-mediated antioxidant effects restore the functionality of angiotensin converting enzyme 2–angiotensin-(1–7)–Mas axis in diabetic rat carotid
  publication-title: Biomed Res Int
  doi: 10.1155/2014/640329
  contributor:
    fullname: Pernomian
– volume: 56
  start-page: 162
  year: 2010
  ident: 10.1016/j.vph.2015.01.001_bb0025
  article-title: An apparent paradox: attenuation of phenylephrine-mediated calcium mobilization and hyperreactivity to phenylephrine in contralateral carotid after balloon injury
  publication-title: J Cardiovasc Pharmacol
  doi: 10.1097/FJC.0b013e3181e571cd
  contributor:
    fullname: Pereira
– volume: 723
  start-page: 397
  year: 2014
  ident: 10.1016/j.vph.2015.01.001_bb0035
  article-title: Impairment of α1-adrenoceptor-mediated calcium influx in contralateral carotids following balloon injury: beneficial effects of superoxide anions
  publication-title: Eur J Pharmacol
  doi: 10.1016/j.ejphar.2013.10.066
  contributor:
    fullname: Pereira
– volume: 18
  start-page: 51
  year: 2013
  ident: 10.1016/j.vph.2015.01.001_bb0140
  article-title: Reciprocal relationship between reactive oxygen species and cyclooxygenase-2 and vascular dysfunction in hypertension
  publication-title: Antioxid Redox Signal
  doi: 10.1089/ars.2011.4335
  contributor:
    fullname: Martínez-Revelles
– volume: 678
  start-page: 15
  year: 2012
  ident: 10.1016/j.vph.2015.01.001_bb0055
  article-title: The role of reactive oxygen species in the modulation of the contraction induced by angiotensin II in carotid artery from diabetic rat
  publication-title: Eur J Pharmacol
  doi: 10.1016/j.ejphar.2011.12.036
  contributor:
    fullname: Pernomian
– volume: 45
  start-page: 1340
  year: 2008
  ident: 10.1016/j.vph.2015.01.001_bb0100
  article-title: Distinct roles of Nox1 and Nox4 in basal and angiotensin II-stimulated superoxide and hydrogen peroxide production
  publication-title: Free Radic Biol Med
  doi: 10.1016/j.freeradbiomed.2008.08.013
  contributor:
    fullname: Dikalov
– volume: 642
  start-page: 121
  year: 2010
  ident: 10.1016/j.vph.2015.01.001_bb0030
  article-title: Impaired calcium influx despite hyper-reactivity in contralateral carotid following balloon injury: eNOS involvement
  publication-title: Eur J Pharmacol
  doi: 10.1016/j.ejphar.2010.05.051
  contributor:
    fullname: Pereira
– volume: 127
  start-page: 1888
  year: 2013
  ident: 10.1016/j.vph.2015.01.001_bb0145
  article-title: NADPH oxidase 1 plays a key role in diabetes mellitus-accelerated atherosclerosis
  publication-title: Circulation
  doi: 10.1161/CIRCULATIONAHA.112.132159
  contributor:
    fullname: Gray
– volume: 32
  start-page: 533
  year: 2009
  ident: 10.1016/j.vph.2015.01.001_bb0065
  article-title: Devil and angel in the renin–angiotensin system: ACE–angiotensin II–AT1 receptor axis vs. ACE2–angiotensin-(1–7)–Mas receptor axis
  publication-title: Hypertens Res
  doi: 10.1038/hr.2009.74
  contributor:
    fullname: Iwai
– volume: 35
  start-page: 284
  year: 2007
  ident: 10.1016/j.vph.2015.01.001_bb0085
  article-title: Inhibition of ALK5 signaling induces physeal dysplasia in rats
  publication-title: Toxicol Pathol
  doi: 10.1080/01926230701198469
  contributor:
    fullname: Frazier
– volume: 23
  start-page: 981
  year: 2003
  ident: 10.1016/j.vph.2015.01.001_bb0180
  article-title: c-Src induces phosphorylation and translocation of p47phox: role in superoxide generation by angiotensin II in human vascular smooth muscle cells
  publication-title: Arterioscler Thromb Vasc Biol
  doi: 10.1161/01.ATV.0000069236.27911.68
  contributor:
    fullname: Touyz
– volume: 25
  start-page: 341
  year: 2005
  ident: 10.1016/j.vph.2015.01.001_bb0175
  article-title: c-Src and hydrogen peroxide mediate transforming growth factor-β1-induced smooth muscle cell — gene expression in 10T1/2 cells
  publication-title: Arterioscler Thromb Vasc Biol
  doi: 10.1161/01.ATV.0000152608.29351.8f
  contributor:
    fullname: Sato
– volume: 163
  start-page: 770
  year: 2011
  ident: 10.1016/j.vph.2015.01.001_bb0040
  article-title: Balloon catheter injury abolishes phenylephrine-induced relaxation in the rat contralateral carotid
  publication-title: Br J Pharmacol
  doi: 10.1111/j.1476-5381.2011.01275.x
  contributor:
    fullname: Pernomian
– volume: 11
  start-page: 112
  year: 2001
  ident: 10.1016/j.vph.2015.01.001_bb0005
  article-title: Carotid angioplasty and stenting: are they therapeutic alternatives?
  publication-title: Cerebrovasc Dis
  doi: 10.1159/000049134
  contributor:
    fullname: Brown
– volume: 49
  start-page: 327
  year: 1983
  ident: 10.1016/j.vph.2015.01.001_bb0010
  article-title: Kinetics of cellular proliferation after arterial injury. I. Smooth muscle growth in the absence of endothelium
  publication-title: Lab Invest
  contributor:
    fullname: Clowes
– volume: 2012
  year: 2012
  ident: 10.1016/j.vph.2015.01.001_bb0070
  article-title: Biosynthetic pathways and the role of the MAS receptor in the effects of angiotensin-(1–7) in smooth muscle
  publication-title: Int J Hypertens
  contributor:
    fullname: de Godoy MA
– volume: 279
  start-page: G1298
  year: 2000
  ident: 10.1016/j.vph.2015.01.001_bb0115
  article-title: NK-1 antagonist reduces colonic inflammation and oxidative stress in dextran sulfate-induced colitis in rats
  publication-title: Am J Physiol Gastrointest Liver Physiol
  doi: 10.1152/ajpgi.2000.279.6.G1298
  contributor:
    fullname: Stucchi
– volume: 8
  start-page: 19
  year: 2009
  ident: 10.1016/j.vph.2015.01.001_bb0075
  article-title: Substance P potentiates TGF-β1 production in lung epithelial cell lines
  publication-title: Iran J Allergy Asthma Immunol
  contributor:
    fullname: Yaraee
– volume: 138
  start-page: 1085
  year: 2003
  ident: 10.1016/j.vph.2015.01.001_bb0105
  article-title: Mechanisms of hydrogen-peroxide-induced biphasic response in rat mesenteric artery
  publication-title: Br J Pharmacol
  doi: 10.1038/sj.bjp.0705147
  contributor:
    fullname: Gao
– volume: 24
  start-page: 13
  year: 2006
  ident: 10.1016/j.vph.2015.01.001_bb0110
  article-title: Phosphoinositide-3-kinase meditated signaling contributes to development of diabetes-induced abnormal vascular reactivity of rat carotid artery
  publication-title: Cell Biochem Funct
  doi: 10.1002/cbf.1278
  contributor:
    fullname: Yousif
– volume: 102
  start-page: 1217
  year: 1986
  ident: 10.1016/j.vph.2015.01.001_bb0160
  article-title: Type β transforming growth factor in human platelets: release during platelet degranulation and action on vascular smooth muscle cells
  publication-title: J Cell Biol
  doi: 10.1083/jcb.102.4.1217
  contributor:
    fullname: Assoain
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Snippet Abstract Balloon injury in diabetic rats triggers a sensory neurocompensatory response that restores the blood flow in contralateral carotid. These...
Balloon injury in diabetic rats triggers a sensory neurocompensatory response that restores the blood flow in contralateral carotid. These vasoprotective...
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SubjectTerms Angiotensin-(1–7)
Animals
Balloon Occlusion - adverse effects
Cardiovascular
Carotid Artery Injuries - metabolism
Carotid Artery Injuries - prevention & control
Carotid balloon injury
Diabetes Mellitus, Experimental - metabolism
Hydrogen peroxide
Male
Proto-Oncogene Proteins - biosynthesis
Rats
Rats, Wistar
Receptors, G-Protein-Coupled - biosynthesis
Signal Transduction - physiology
TGFβ1
Transforming Growth Factor beta1 - metabolism
Type I-diabetes
Vasodilation - physiology
Title Vasoprotective effects of neurocompensatory response to balloon injury during diabetes involve the improvement of Mas signaling by TGFβ1 activation
URI https://www.clinicalkey.es/playcontent/1-s2.0-S1537189115000038
https://dx.doi.org/10.1016/j.vph.2015.01.001
https://www.ncbi.nlm.nih.gov/pubmed/25595661
https://search.proquest.com/docview/1657317493
Volume 64
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