Morphine Use in Hospitalized Children in the United States: A Descriptive Analysis of Data From Pediatric Hospitalizations in 2008
Abstract Background Morphine is among the top 10 medications given to children in the inpatient setting. It is not labeled for any pediatric indication, making it one of the drugs most widely used off-label in pediatrics. Objectives The aims of this study were to describe the epidemiology of morphin...
Saved in:
Published in | Clinical therapeutics Vol. 34; no. 3; pp. 720 - 727 |
---|---|
Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
United States
EM Inc USA
01.03.2012
Elsevier Limited |
Subjects | |
Online Access | Get full text |
Cover
Loading…
Abstract | Abstract Background Morphine is among the top 10 medications given to children in the inpatient setting. It is not labeled for any pediatric indication, making it one of the drugs most widely used off-label in pediatrics. Objectives The aims of this study were to describe the epidemiology of morphine use in pediatric inpatients in the United States and to describe the characteristics of patients and hospitals in hospitalizations with morphine use. Methods Deidentified data from the Premier Perspective Database (2008) were analyzed. Morphine use was defined as any morphine administration during the hospital stay and estimated by patient age in years, sex, race, and type of insurance; and hospital bedsize, teaching status, setting (urban or rural), and geographic location. Proportions (95% CI) were calculated for the entire population and for individual strata. The estimate was applied to national data to calculate the number of pediatric hospitalizations with morphine use in the United States in 2008. Logistic mixed-effects modeling was used to calculate the probability of morphine use by hospital after controlling for hospital and patient effects. Results The database contained records from 877,201 pediatric hospitalizations and 423 hospitals in the United States. Morphine was administered in 54,613 of pediatric hospitalizations (6.2%). Use was higher in boys than girls (6.4% and 6.1%, respectively) and in blacks compared with whites or other racial groups (7.5%, 6.7%, and 5.0%). Use increased from 1.6% in children aged <2 years to 27.4% in those aged 12 to 17 years. Based on these data, morphine may have been administered in 476,205 pediatric hospitalizations in the United States in 2008. The 2 diagnoses most frequently associated with morphine use were appendicitis (14.4%) and fracture (11.1%). On logistic mixed-effects modeling for patients with appendicitis and for patients with fractures, there was hospital variation in morphine use after controlling for variables in the model. Conclusions Based on the data from this analysis, morphine was used in hospitalized children in all age groups, despite the lack of pediatric labeling. Common conditions such as appendicitis and fracture were leading diagnoses associated with morphine use. |
---|---|
AbstractList | Morphine is among the top 10 medications given to children in the inpatient setting. It is not labeled for any pediatric indication, making it one of the drugs most widely used off-label in pediatrics. The aims of this study were to describe the epidemiology of morphine use in pediatric inpatients in the United States and to describe the characteristics of patients and hospitals in hospitalizations with morphine use. Deidentified data from the Premier Perspective Database (2008) were analyzed. Morphine use was defined as any morphine administration during the hospital stay and estimated by patient age in years, sex, race, and type of insurance; and hospital bedsize, teaching status, setting (urban or rural), and geographic location. Proportions (95% CI) were calculated for the entire population and for individual strata. The estimate was applied to national data to calculate the number of pediatric hospitalizations with morphine use in the United States in 2008. Logistic mixed-effects modeling was used to calculate the probability of morphine use by hospital after controlling for hospital and patient effects. The database contained records from 877,201 pediatric hospitalizations and 423 hospitals in the United States. Morphine was administered in 54,613 of pediatric hospitalizations (6.2%). Use was higher in boys than girls (6.4% and 6.1%, respectively) and in blacks compared with whites or other racial groups (7.5%, 6.7%, and 5.0%). Use increased from 1.6% in children aged <2 years to 27.4% in those aged 12 to 17 years. Based on these data, morphine may have been administered in 476,205 pediatric hospitalizations in the United States in 2008. The 2 diagnoses most frequently associated with morphine use were appendicitis (14.4%) and fracture (11.1%). On logistic mixed-effects modeling for patients with appendicitis and for patients with fractures, there was hospital variation in morphine use after controlling for variables in the model. Based on the data from this analysis, morphine was used in hospitalized children in all age groups, despite the lack of pediatric labeling. Common conditions such as appendicitis and fracture were leading diagnoses associated with morphine use. Abstract Background Morphine is among the top 10 medications given to children in the inpatient setting. It is not labeled for any pediatric indication, making it one of the drugs most widely used off-label in pediatrics. Objectives The aims of this study were to describe the epidemiology of morphine use in pediatric inpatients in the United States and to describe the characteristics of patients and hospitals in hospitalizations with morphine use. Methods Deidentified data from the Premier Perspective Database (2008) were analyzed. Morphine use was defined as any morphine administration during the hospital stay and estimated by patient age in years, sex, race, and type of insurance; and hospital bedsize, teaching status, setting (urban or rural), and geographic location. Proportions (95% CI) were calculated for the entire population and for individual strata. The estimate was applied to national data to calculate the number of pediatric hospitalizations with morphine use in the United States in 2008. Logistic mixed-effects modeling was used to calculate the probability of morphine use by hospital after controlling for hospital and patient effects. Results The database contained records from 877,201 pediatric hospitalizations and 423 hospitals in the United States. Morphine was administered in 54,613 of pediatric hospitalizations (6.2%). Use was higher in boys than girls (6.4% and 6.1%, respectively) and in blacks compared with whites or other racial groups (7.5%, 6.7%, and 5.0%). Use increased from 1.6% in children aged <2 years to 27.4% in those aged 12 to 17 years. Based on these data, morphine may have been administered in 476,205 pediatric hospitalizations in the United States in 2008. The 2 diagnoses most frequently associated with morphine use were appendicitis (14.4%) and fracture (11.1%). On logistic mixed-effects modeling for patients with appendicitis and for patients with fractures, there was hospital variation in morphine use after controlling for variables in the model. Conclusions Based on the data from this analysis, morphine was used in hospitalized children in all age groups, despite the lack of pediatric labeling. Common conditions such as appendicitis and fracture were leading diagnoses associated with morphine use. Morphine is among the top 10 medications given to children in the inpatient setting. It is not labeled for any pediatric indication, making it one of the drugs most widely used off-label in pediatrics. The aims of this study were to describe the epidemiology of morphine use in pediatric inpatients in the United States and to describe the characteristics of patients and hospitals in hospitalizations with morphine use. Deidentified data from the Premier Perspective Database (2008) were analyzed. Morphine use was defined as any morphine administration during the hospital stay and estimated by patient age in years, sex, race, and type of insurance; and hospital bedsize, teaching status, setting (urban or rural), and geographic location. Proportions (95% CI) were calculated for the entire population and for individual strata. The estimate was applied to national data to calculate the number of pediatric hospitalizations with morphine use in the United States in 2008. Logistic mixed-effects modeling was used to calculate the probability of morphine use by hospital after controlling for hospital and patient effects. The database contained records from 877,201 pediatric hospitalizations and 423 hospitals in the United States. Morphine was administered in 54,613 of pediatric hospitalizations (6.2%). Use was higher in boys than girls (6.4% and 6.1%, respectively) and in blacks compared with whites or other racial groups (7.5%, 6.7%, and 5.0%). Use increased from 1.6% in children aged <2 years to 27.4% in those aged 12 to 17 years. Based on these data, morphine may have been administered in 476,205 pediatric hospitalizations in the United States in 2008. The 2 diagnoses most frequently associated with morphine use were appendicitis (14.4%) and fracture (11.1%). On logistic mixed-effects modeling for patients with appendicitis and for patients with fractures, there was hospital variation in morphine use after controlling for variables in the model. Based on the data from this analysis, morphine was used in hospitalized children in all age groups, despite the lack of pediatric labeling. Common conditions such as appendicitis and fracture were leading diagnoses associated with morphine use. BACKGROUNDMorphine is among the top 10 medications given to children in the inpatient setting. It is not labeled for any pediatric indication, making it one of the drugs most widely used off-label in pediatrics.OBJECTIVESThe aims of this study were to describe the epidemiology of morphine use in pediatric inpatients in the United States and to describe the characteristics of patients and hospitals in hospitalizations with morphine use.METHODSDeidentified data from the Premier Perspective Database (2008) were analyzed. Morphine use was defined as any morphine administration during the hospital stay and estimated by patient age in years, sex, race, and type of insurance; and hospital bedsize, teaching status, setting (urban or rural), and geographic location. Proportions (95% CI) were calculated for the entire population and for individual strata. The estimate was applied to national data to calculate the number of pediatric hospitalizations with morphine use in the United States in 2008. Logistic mixed-effects modeling was used to calculate the probability of morphine use by hospital after controlling for hospital and patient effects.RESULTSThe database contained records from 877,201 pediatric hospitalizations and 423 hospitals in the United States. Morphine was administered in 54,613 of pediatric hospitalizations (6.2%). Use was higher in boys than girls (6.4% and 6.1%, respectively) and in blacks compared with whites or other racial groups (7.5%, 6.7%, and 5.0%). Use increased from 1.6% in children aged <2 years to 27.4% in those aged 12 to 17 years. Based on these data, morphine may have been administered in 476,205 pediatric hospitalizations in the United States in 2008. The 2 diagnoses most frequently associated with morphine use were appendicitis (14.4%) and fracture (11.1%). On logistic mixed-effects modeling for patients with appendicitis and for patients with fractures, there was hospital variation in morphine use after controlling for variables in the model.CONCLUSIONSBased on the data from this analysis, morphine was used in hospitalized children in all age groups, despite the lack of pediatric labeling. Common conditions such as appendicitis and fracture were leading diagnoses associated with morphine use. |
Author | Lasky, Tamar, PhD Ernst, Frank R., PharmD, MS Gonzalez, Liliana, PhD Greenspan, Jay, MD, MBA |
Author_xml | – sequence: 1 fullname: Lasky, Tamar, PhD – sequence: 2 fullname: Greenspan, Jay, MD, MBA – sequence: 3 fullname: Ernst, Frank R., PharmD, MS – sequence: 4 fullname: Gonzalez, Liliana, PhD |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/22381715$$D View this record in MEDLINE/PubMed |
BookMark | eNqNklFrFDEQx4NU7LX6FTTgg097Zja7m40PwnG1Vqgo1APfQjY7y-XcS65JrnA--snNcrVKn4SBQOY3_2HmP2fkxHmHhLwCNgcGzdvN3IzWpTUGPS8ZlHMGOZonZAatkAVA9f2EzBhUsigltKfkLMYNY4zLunxGTsuStyCgnpFfn33Yra1DuopIraNXPu5s0qP9iT1dru3YB3RTIjejK2dT_r5JOmF8Rxf0AqMJdpfsHdKF0-Mh2kj9QC900vQy-C39ir3VKVjzj7JO1rs4iZaMtc_J00GPEV_cv-dkdfnh2_KquP7y8dNycV2YSrSpqGooBR-glU3XMwGaN6Iuu2YwQy2MbgVKIbpKGwGIVYVcVJ2oZN2znpccOn5O3hx1d8Hf7jEmtbXR4Dhqh34flazaVjJWi0y-fkRu_D7k8aICxjk0rG7qTIkjZYKPMeCgdsFudThkSE0uqY16cElNLikGOZpc-fJef99tsX-o-2NLBhZHAPM-7iwGFY1FZ_IuA5qkem__o8n7RxoTZ40ef-AB49-JVMw16mY6lulWIHvCatny3wXivUA |
CitedBy_id | crossref_primary_10_1055_s_0043_1777741 crossref_primary_10_1007_s40801_015_0049_y crossref_primary_10_1016_j_peptides_2014_09_013 crossref_primary_10_1016_j_jpainsymman_2013_12_241 crossref_primary_10_1016_j_surg_2020_04_060 crossref_primary_10_1016_j_jss_2020_05_022 crossref_primary_10_1038_tpj_2014_56 crossref_primary_10_1111_jpc_12875 |
Cites_doi | 10.1097/00004630-200301000-00007 10.1111/j.1526-4637.2006.00252.x 10.1097/MLR.0b013e318070c07b 10.1353/hpu.0.0236 10.1177/1062860609359934 10.1002/14651858.CD003350.pub2 10.1016/S0140-6736(06)68230-5 10.1053/ajem.2002.33002 10.1016/j.clp.2008.09.007 10.1136/adc.2005.082263 10.1002/pds.2063 10.1001/archpedi.161.3.282 10.1542/peds.110.1.181 |
ContentType | Journal Article |
Copyright | Elsevier HS Journals, Inc. 2012 Elsevier HS Journals, Inc. Copyright © 2012 Elsevier HS Journals, Inc. All rights reserved. |
Copyright_xml | – notice: Elsevier HS Journals, Inc. – notice: 2012 Elsevier HS Journals, Inc. – notice: Copyright © 2012 Elsevier HS Journals, Inc. All rights reserved. |
DBID | CGR CUY CVF ECM EIF NPM AAYXX CITATION 3V. 7RV 7X7 7XB 88C 88E 8AO 8FI 8FJ 8FK 8G5 ABUWG AFKRA AZQEC BENPR CCPQU DWQXO FYUFA GHDGH GNUQQ GUQSH K9. KB0 M0S M0T M1P M2O M7N MBDVC NAPCQ PQEST PQQKQ PQUKI PRINS Q9U 7X8 |
DOI | 10.1016/j.clinthera.2012.01.016 |
DatabaseName | Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed CrossRef ProQuest Central (Corporate) Nursing & Allied Health Database Health & Medical Collection ProQuest Central (purchase pre-March 2016) Healthcare Administration Database (Alumni) Medical Database (Alumni Edition) ProQuest Pharma Collection Hospital Premium Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) Research Library (Alumni Edition) ProQuest Central (Alumni) ProQuest Central ProQuest Central Essentials ProQuest Central ProQuest One Community College ProQuest Central Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Central Student Research Library Prep ProQuest Health & Medical Complete (Alumni) Nursing & Allied Health Database (Alumni Edition) Health & Medical Collection (Alumni Edition) Healthcare Administration Database Medical Database Research Library Algology Mycology and Protozoology Abstracts (Microbiology C) Research Library (Corporate) Nursing & Allied Health Premium ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Academic ProQuest One Academic UKI Edition ProQuest Central China ProQuest Central Basic MEDLINE - Academic |
DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) CrossRef Research Library Prep ProQuest Central Student ProQuest Central Essentials ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) ProQuest One Community College Research Library (Alumni Edition) ProQuest Pharma Collection ProQuest Central China ProQuest Central Health Research Premium Collection Health and Medicine Complete (Alumni Edition) ProQuest Central Korea Algology Mycology and Protozoology Abstracts (Microbiology C) ProQuest Research Library ProQuest Medical Library (Alumni) ProQuest Central Basic ProQuest One Academic Eastern Edition ProQuest Health Management ProQuest Nursing & Allied Health Source ProQuest Hospital Collection Health Research Premium Collection (Alumni) ProQuest Hospital Collection (Alumni) Nursing & Allied Health Premium ProQuest Health & Medical Complete ProQuest Medical Library ProQuest One Academic UKI Edition ProQuest Health Management (Alumni Edition) ProQuest Nursing & Allied Health Source (Alumni) ProQuest One Academic ProQuest Central (Alumni) MEDLINE - Academic |
DatabaseTitleList | Research Library Prep MEDLINE MEDLINE - Academic |
Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database – sequence: 3 dbid: BENPR name: ProQuest Central url: https://www.proquest.com/central sourceTypes: Aggregation Database |
DeliveryMethod | fulltext_linktorsrc |
Discipline | Medicine Pharmacy, Therapeutics, & Pharmacology |
EISSN | 1879-114X |
EndPage | 727 |
ExternalDocumentID | 2734249081 10_1016_j_clinthera_2012_01_016 22381715 S0149291812000598 1_s2_0_S0149291812000598 |
Genre | Research Support, U.S. Gov't, P.H.S Journal Article |
GeographicLocations | United States United States--US Minnesota |
GeographicLocations_xml | – name: United States – name: Minnesota – name: United States--US |
GrantInformation_xml | – fundername: AHRQ HHS grantid: R03 HS017998 |
GroupedDBID | --- --K --M .1- .FO .GJ .~1 0R~ 0SF 123 1B1 1P~ 1~. 1~5 29B 3V. 4.4 457 4G. 53G 5RE 5VS 6J9 6PF 7-5 71M 7RV 7X7 88E 8AO 8FI 8FJ 8G5 8P~ AABNK AACTN AAEDT AAEDW AAIKJ AAKOC AALRI AAOAW AAQFI AAQQT AAQXK AAWTL AAXKI AAXUO AAYOK ABBQC ABFNM ABFRF ABJNI ABMAC ABMZM ABUWG ABXDB ABZDS ACDAQ ACPRK ACRLP ADBBV ADEZE ADFRT ADMUD ADVLN AEBSH AEFWE AEKER AENEX AEVXI AFCTW AFFNX AFJKZ AFKRA AFKWA AFRAH AFRHN AFTJW AFXIZ AGHFR AGUBO AGYEJ AHMBA AIEXJ AIKHN AITUG AJOXV AJRQY AJUYK AKRWK ALCLG ALIPV ALMA_UNASSIGNED_HOLDINGS AMFUW AMRAJ ANZVX AQUVI ASPBG AVWKF AXJTR AZFZN AZQEC BENPR BKEYQ BKOJK BLXMC BNPGV BPHCQ BVXVI CCPQU CS3 DU5 DWQXO EBS EFJIC EJD EMOBN EO8 EO9 EP2 EP3 EX3 F5P FDB FEDTE FGOYB FIRID FNPLU FYGXN FYUFA G-Q GBLVA GNUQQ GUQSH HVGLF HZ~ H~9 IHE J1W KOM M0T M1P M2O M41 MO0 N9A NAPCQ NCXOZ O-L O9- OAUVE OD~ OGGZJ OO0 OZT P-8 P-9 PC. PQQKQ PROAC PSQYO Q38 R2- RIG ROL RPZ SCC SDF SDG SEL SES SEW SPCBC SSH SSP SSZ SV3 T5K UHS WH7 WOW XOL Z5R ZGI ZXP ~G- AAIAV AATCM ABLVK ABYKQ AJBFU EFLBG HMCUK LCYCR UKHRP CGR CUY CVF ECM EIF NPM AAYXX CITATION 7XB 8FK K9. M7N MBDVC PQEST PQUKI PRINS Q9U 7X8 |
ID | FETCH-LOGICAL-c478t-451273f1896bd071a36752b6fcf57ca87e977b4ac71ee44e374b7495d0d3231b3 |
IEDL.DBID | BENPR |
ISSN | 0149-2918 |
IngestDate | Fri Aug 16 08:15:47 EDT 2024 Thu Oct 10 22:52:36 EDT 2024 Thu Sep 26 19:37:32 EDT 2024 Sat Sep 28 08:05:41 EDT 2024 Fri Feb 23 02:23:23 EST 2024 Tue Oct 15 22:54:44 EDT 2024 |
IsPeerReviewed | true |
IsScholarly | true |
Issue | 3 |
Keywords | database hospitalization children morphine pharmacoepidemiology |
Language | English |
License | Copyright © 2012 Elsevier HS Journals, Inc. All rights reserved. |
LinkModel | DirectLink |
MergedId | FETCHMERGED-LOGICAL-c478t-451273f1896bd071a36752b6fcf57ca87e977b4ac71ee44e374b7495d0d3231b3 |
Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
PMID | 22381715 |
PQID | 1033160565 |
PQPubID | 1226358 |
PageCount | 8 |
ParticipantIDs | proquest_miscellaneous_948890057 proquest_journals_1033160565 crossref_primary_10_1016_j_clinthera_2012_01_016 pubmed_primary_22381715 elsevier_sciencedirect_doi_10_1016_j_clinthera_2012_01_016 elsevier_clinicalkeyesjournals_1_s2_0_S0149291812000598 |
PublicationCentury | 2000 |
PublicationDate | 2012-03-01 |
PublicationDateYYYYMMDD | 2012-03-01 |
PublicationDate_xml | – month: 03 year: 2012 text: 2012-03-01 day: 01 |
PublicationDecade | 2010 |
PublicationPlace | United States |
PublicationPlace_xml | – name: United States – name: Bridgewater |
PublicationTitle | Clinical therapeutics |
PublicationTitleAlternate | Clin Ther |
PublicationYear | 2012 |
Publisher | EM Inc USA Elsevier Limited |
Publisher_xml | – name: EM Inc USA – name: Elsevier Limited |
References | Vanchieri, Butler, Knutsen (bib14) 2008 Dai, Li, Rocke (bib19) 2006 Dunlop, Bennett (bib12) 2006; 2 (bib25) 2002; 110 Shah, Hall, Goodman (bib4) 2007; 161 Selvin (bib16) 1996 Li, Alterman, Deddens (bib20) 2006 (bib21) 2009 (bib11) 2006 (bib22) 2009 Lasky, Ernst, Greenspan (bib1) 2011; 20 Anand, Hall (bib6) 2006; 91 (bib15) 2008 Hall, Shbarou (bib7) 2009; 36 Martin-Herz, Patterson, Honari (bib10) 2003; 24 Krauss, Green (bib5) 2006; 367 (bib23) 2006 Hsu, Brazelton (bib3) 2009; 108 Jacob, Mueller (bib9) 2008; 9 Jiminez, Seidel, Martin (bib24) 2010; 21 Horn, Gassaway (bib26) 2007; 45 (bib13) 2005; 70 Schabenberger (bib18) 2005 Lasky, Lawless, Greenspan (bib2) 2010; 25 Hostetler, Auinger, Szilagyi (bib8) 2002; 20 Hughes (bib17) 2008 (10.1016/j.clinthera.2012.01.016_bib21) 2009 (10.1016/j.clinthera.2012.01.016_bib11) 2006 Dunlop (10.1016/j.clinthera.2012.01.016_bib12) 2006; 2 Jiminez (10.1016/j.clinthera.2012.01.016_bib24) 2010; 21 Lasky (10.1016/j.clinthera.2012.01.016_bib2) 2010; 25 Krauss (10.1016/j.clinthera.2012.01.016_bib5) 2006; 367 Shah (10.1016/j.clinthera.2012.01.016_bib4) 2007; 161 Anand (10.1016/j.clinthera.2012.01.016_bib6) 2006; 91 (10.1016/j.clinthera.2012.01.016_bib23) 2006 Hall (10.1016/j.clinthera.2012.01.016_bib7) 2009; 36 Hostetler (10.1016/j.clinthera.2012.01.016_bib8) 2002; 20 Horn (10.1016/j.clinthera.2012.01.016_bib26) 2007; 45 Li (10.1016/j.clinthera.2012.01.016_bib20) 2006 Schabenberger (10.1016/j.clinthera.2012.01.016_bib18) 2005 Jacob (10.1016/j.clinthera.2012.01.016_bib9) 2008; 9 Lasky (10.1016/j.clinthera.2012.01.016_bib1) 2011; 20 Hsu (10.1016/j.clinthera.2012.01.016_bib3) 2009; 108 Martin-Herz (10.1016/j.clinthera.2012.01.016_bib10) 2003; 24 Hughes (10.1016/j.clinthera.2012.01.016_bib17) 2008 (10.1016/j.clinthera.2012.01.016_bib15) 2008 Selvin (10.1016/j.clinthera.2012.01.016_bib16) 1996 (10.1016/j.clinthera.2012.01.016_bib13) 2005; 70 (10.1016/j.clinthera.2012.01.016_bib25) 2002; 110 Dai (10.1016/j.clinthera.2012.01.016_bib19) 2006 Vanchieri (10.1016/j.clinthera.2012.01.016_bib14) 2008 (10.1016/j.clinthera.2012.01.016_bib22) 2009 |
References_xml | – volume: 21 start-page: 229 year: 2010 end-page: 236 ident: bib24 article-title: Perioperative analgesic treatment in Latino and non-Latino pediatric patients publication-title: J Health Care Poor Underserved contributor: fullname: Martin – volume: 161 start-page: 282 year: 2007 end-page: 290 ident: bib4 article-title: Off-label drug use in hospitalized children publication-title: Arch Pediatr Adolesc Med contributor: fullname: Goodman – year: 2009 ident: bib21 article-title: SAS/GRAPH 9.2: StatisticalGraphics Procedures Guide – year: 2006 ident: bib11 article-title: Morphine sulfate – year: 2006 ident: bib23 article-title: HCUP Kids' Inpatient Database (KID) Healthcare Cost and Utilization Project (HCUP) 2000, 2003, 2006 – volume: 110 start-page: 181 year: 2002 end-page: 183 ident: bib25 article-title: Uses of drugs not described in the package insert (off-label uses) publication-title: Pediatrics – volume: 36 start-page: 15 year: 2009 end-page: 26 ident: bib7 article-title: Drugs of choice for sedation and analgesia in the NICU publication-title: Clin Perinatol contributor: fullname: Shbarou – volume: 20 start-page: 139 year: 2002 end-page: 143 ident: bib8 article-title: Parenteral analgesic and sedative use among ED patients in the United States: combined results from the National Hospital Ambulatory Medical Care Survey (NHAMCS), 1992–1997 publication-title: Am J Emerg Med contributor: fullname: Szilagyi – year: 2008 ident: bib15 article-title: Premier Perspective Database – year: 2009 ident: bib22 article-title: Base SAS 9.2 Procedures Guide: Statistical Procedures – year: 2006 ident: bib19 article-title: Hierarchical Logistic Regression Modeling with SAS GLIMMIX contributor: fullname: Rocke – year: 2008 ident: bib17 article-title: Development of the 3M All Patient Refined Diagnosis Related Groups (APR DRGs) contributor: fullname: Hughes – year: 2005 ident: bib18 article-title: Introducing the GLIMMIX Procedure for General Linear Mixed Models contributor: fullname: Schabenberger – volume: 45 start-page: S50 year: 2007 end-page: S57 ident: bib26 article-title: Practice-based evidence study design for comparative effectiveness research publication-title: Medical Care contributor: fullname: Gassaway – volume: 2 year: 2006 ident: bib12 article-title: Pain management for sickle cell disease publication-title: Cochrane Database Syst Rev contributor: fullname: Bennett – year: 2006 ident: bib20 article-title: Analysis of Large Hierarchical Data with Multilevel Logistic Modeling Using PROC GLIMMIX contributor: fullname: Deddens – volume: 25 start-page: 225 year: 2010 end-page: 231 ident: bib2 article-title: Quality care for children: inpatient medication use in a mid-Atlantic hospital system 2000–2003 publication-title: Am J Med Qual contributor: fullname: Greenspan – volume: 24 start-page: 26 year: 2003 end-page: 36 ident: bib10 article-title: Pediatric pain control practices of North American burn centers publication-title: J Burn Care Rehabil contributor: fullname: Honari – volume: 9 start-page: 13 year: 2008 end-page: 21 ident: bib9 article-title: Pain experience of children with sickle cell disease who had prolonged hospitalizations for acute painful episodes publication-title: Pain Med contributor: fullname: Mueller – volume: 20 start-page: 76 year: 2011 end-page: 82 ident: bib1 article-title: Estimating pediatric inpatient medication use in the United States publication-title: Pharmacoepidemiol Drug Saf contributor: fullname: Greenspan – volume: 367 start-page: 766 year: 2006 end-page: 780 ident: bib5 article-title: Procedural sedation and analgesia in children publication-title: Lancet contributor: fullname: Green – volume: 108 start-page: 343 year: 2009 end-page: 348 ident: bib3 article-title: Off-label medication use in an academic hospital pediatric critical care unit publication-title: WMJ contributor: fullname: Brazelton – volume: 91 start-page: F448 year: 2006 end-page: F453 ident: bib6 article-title: Pharmacological therapy for analgesia and sedation in the newborn publication-title: Arch Dis Child Fetal Neonatal Ed contributor: fullname: Hall – volume: 70 start-page: 3937 year: 2005 ident: bib13 article-title: List of drugs for which pediatric studies are needed publication-title: Fed Reg – year: 2008 ident: bib14 article-title: Addressing the barriers to pediatric drug development: workshop summary contributor: fullname: Knutsen – year: 1996 ident: bib16 article-title: Statistical Analysis of Epidemiologic Data contributor: fullname: Selvin – volume: 24 start-page: 26 year: 2003 ident: 10.1016/j.clinthera.2012.01.016_bib10 article-title: Pediatric pain control practices of North American burn centers publication-title: J Burn Care Rehabil doi: 10.1097/00004630-200301000-00007 contributor: fullname: Martin-Herz – year: 2006 ident: 10.1016/j.clinthera.2012.01.016_bib20 contributor: fullname: Li – volume: 9 start-page: 13 year: 2008 ident: 10.1016/j.clinthera.2012.01.016_bib9 article-title: Pain experience of children with sickle cell disease who had prolonged hospitalizations for acute painful episodes publication-title: Pain Med doi: 10.1111/j.1526-4637.2006.00252.x contributor: fullname: Jacob – volume: 45 start-page: S50 issue: Suppl year: 2007 ident: 10.1016/j.clinthera.2012.01.016_bib26 article-title: Practice-based evidence study design for comparative effectiveness research publication-title: Medical Care doi: 10.1097/MLR.0b013e318070c07b contributor: fullname: Horn – volume: 21 start-page: 229 year: 2010 ident: 10.1016/j.clinthera.2012.01.016_bib24 article-title: Perioperative analgesic treatment in Latino and non-Latino pediatric patients publication-title: J Health Care Poor Underserved doi: 10.1353/hpu.0.0236 contributor: fullname: Jiminez – year: 2008 ident: 10.1016/j.clinthera.2012.01.016_bib15 – year: 2006 ident: 10.1016/j.clinthera.2012.01.016_bib23 article-title: HCUP Kids' Inpatient Database (KID) Healthcare Cost and Utilization Project (HCUP) 2000, 2003, 2006 – volume: 108 start-page: 343 year: 2009 ident: 10.1016/j.clinthera.2012.01.016_bib3 article-title: Off-label medication use in an academic hospital pediatric critical care unit publication-title: WMJ contributor: fullname: Hsu – year: 2009 ident: 10.1016/j.clinthera.2012.01.016_bib21 – volume: 25 start-page: 225 year: 2010 ident: 10.1016/j.clinthera.2012.01.016_bib2 article-title: Quality care for children: inpatient medication use in a mid-Atlantic hospital system 2000–2003 publication-title: Am J Med Qual doi: 10.1177/1062860609359934 contributor: fullname: Lasky – volume: 2 year: 2006 ident: 10.1016/j.clinthera.2012.01.016_bib12 article-title: Pain management for sickle cell disease publication-title: Cochrane Database Syst Rev doi: 10.1002/14651858.CD003350.pub2 contributor: fullname: Dunlop – volume: 367 start-page: 766 year: 2006 ident: 10.1016/j.clinthera.2012.01.016_bib5 article-title: Procedural sedation and analgesia in children publication-title: Lancet doi: 10.1016/S0140-6736(06)68230-5 contributor: fullname: Krauss – volume: 20 start-page: 139 year: 2002 ident: 10.1016/j.clinthera.2012.01.016_bib8 article-title: Parenteral analgesic and sedative use among ED patients in the United States: combined results from the National Hospital Ambulatory Medical Care Survey (NHAMCS), 1992–1997 publication-title: Am J Emerg Med doi: 10.1053/ajem.2002.33002 contributor: fullname: Hostetler – year: 2008 ident: 10.1016/j.clinthera.2012.01.016_bib14 article-title: Addressing the barriers to pediatric drug development: workshop summary contributor: fullname: Vanchieri – volume: 36 start-page: 15 year: 2009 ident: 10.1016/j.clinthera.2012.01.016_bib7 article-title: Drugs of choice for sedation and analgesia in the NICU publication-title: Clin Perinatol doi: 10.1016/j.clp.2008.09.007 contributor: fullname: Hall – year: 2006 ident: 10.1016/j.clinthera.2012.01.016_bib11 – year: 2009 ident: 10.1016/j.clinthera.2012.01.016_bib22 article-title: Base SAS 9.2 Procedures Guide: Statistical Procedures – volume: 91 start-page: F448 year: 2006 ident: 10.1016/j.clinthera.2012.01.016_bib6 article-title: Pharmacological therapy for analgesia and sedation in the newborn publication-title: Arch Dis Child Fetal Neonatal Ed doi: 10.1136/adc.2005.082263 contributor: fullname: Anand – year: 2006 ident: 10.1016/j.clinthera.2012.01.016_bib19 article-title: Hierarchical Logistic Regression Modeling with SAS GLIMMIX contributor: fullname: Dai – volume: 20 start-page: 76 year: 2011 ident: 10.1016/j.clinthera.2012.01.016_bib1 article-title: Estimating pediatric inpatient medication use in the United States publication-title: Pharmacoepidemiol Drug Saf doi: 10.1002/pds.2063 contributor: fullname: Lasky – year: 1996 ident: 10.1016/j.clinthera.2012.01.016_bib16 contributor: fullname: Selvin – year: 2005 ident: 10.1016/j.clinthera.2012.01.016_bib18 article-title: Introducing the GLIMMIX Procedure for General Linear Mixed Models contributor: fullname: Schabenberger – volume: 70 start-page: 3937 year: 2005 ident: 10.1016/j.clinthera.2012.01.016_bib13 article-title: List of drugs for which pediatric studies are needed publication-title: Fed Reg – volume: 161 start-page: 282 year: 2007 ident: 10.1016/j.clinthera.2012.01.016_bib4 article-title: Off-label drug use in hospitalized children publication-title: Arch Pediatr Adolesc Med doi: 10.1001/archpedi.161.3.282 contributor: fullname: Shah – year: 2008 ident: 10.1016/j.clinthera.2012.01.016_bib17 article-title: Development of the 3M All Patient Refined Diagnosis Related Groups (APR DRGs) contributor: fullname: Hughes – volume: 110 start-page: 181 year: 2002 ident: 10.1016/j.clinthera.2012.01.016_bib25 article-title: Uses of drugs not described in the package insert (off-label uses) publication-title: Pediatrics doi: 10.1542/peds.110.1.181 |
SSID | ssj0003952 |
Score | 2.1008089 |
Snippet | Abstract Background Morphine is among the top 10 medications given to children in the inpatient setting. It is not labeled for any pediatric indication, making... Morphine is among the top 10 medications given to children in the inpatient setting. It is not labeled for any pediatric indication, making it one of the drugs... BACKGROUNDMorphine is among the top 10 medications given to children in the inpatient setting. It is not labeled for any pediatric indication, making it one of... |
SourceID | proquest crossref pubmed elsevier |
SourceType | Aggregation Database Index Database Publisher |
StartPage | 720 |
SubjectTerms | Adolescent Analgesics, Opioid - administration & dosage Analgesics, Opioid - therapeutic use Child Child, Hospitalized - statistics & numerical data Child, Preschool children Children & youth Databases, Factual Drug Utilization - statistics & numerical data Drug Utilization - trends Female Hospitalization Hospitalization - statistics & numerical data Humans Infant Internal Medicine Logistic Models Male Medical Education morphine Morphine - administration & dosage Morphine - therapeutic use Mortality pharmacoepidemiology Studies United States |
SummonAdditionalLinks | – databaseName: ScienceDirect Freedom Collection Journals dbid: AIKHN link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1La9wwEB7SDZReSpq-nCZlDiWnmLVWsmXntmyybFs25JCF3IRsybCF2CHeFNJjfnlHlu1taEsPBV9sPa2RZj5J8wD4pAnlyjgrQy1iE4o4j8KcmTSUvCwyxk2m2wO35UWyWIkv1_H1Dsx6WxinVtnxfs_TW27dfRl3ozm-Xa_HTi2JZLuTUK2XkfQZ7JI4EmIEu9PPXxcXA0PmWRt4x-UPXYEnal7OALE1dXJqXpPWhaeLff5nIfU3ENoKo_kevOxQJE59R1_Bjq324fmyuyffh-NL75H64QSvtgZWzQke4-XWV_XDa3hc1jTQVAZXjcV1hX0ckfUPa3DWWXq7BOo9eoCKHqCe4hRp1-q5zneLvXsTrEs80xuN87v6BodQIL_U7A8JXaVOLeINrObnV7NF2IVlCAsh0w0RlBHmKVmaJbkhhKI5bTomzmiojGWhU2kJU-ZCF5JZK4TlUuSS9mEmMpzQZM7fwqiqK_sesEhMXKSpjfKScgqrZZTm2iTGcsIhTAcQ9XRQt977hurV0r6pgXTKkU5FjJ4kANnTS_XGpcQObdOtzUYx1VBm9dv8CeB0KPlkCiqSLv9u9rCfG2rbUsQ5o_1iEgeAQzKtX3cpoytb3zcqIw6aOZPgAN75KTX86cTBKcnig__p2Ad44d682twhjDZ39_aIcNQm_9itk58H3xuL priority: 102 providerName: Elsevier |
Title | Morphine Use in Hospitalized Children in the United States: A Descriptive Analysis of Data From Pediatric Hospitalizations in 2008 |
URI | https://www.clinicalkey.es/playcontent/1-s2.0-S0149291812000598 https://dx.doi.org/10.1016/j.clinthera.2012.01.016 https://www.ncbi.nlm.nih.gov/pubmed/22381715 https://www.proquest.com/docview/1033160565 https://search.proquest.com/docview/948890057 |
Volume | 34 |
hasFullText | 1 |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwhV1La9wwEB6aLJReSpq-3KSLDiWnuFiWbNm5lG2aZduyy1KysDchWzIkUDuNN4X00EN-eUaW7G2hDzC-6GnPaPRJ8wJ4oxDliiSvQsUTHfKkiMKC6iwUrCpzynSuugu3-SKdrfindbL2F26tN6vsZWInqHVT2jtyXN2MUcTeafLu6ltos0ZZ7apPobEDo5hyq6YdvT9bLL8MspjlXc4dew4I45xmv1l4Wd_DzsvJWnjFXfROm_b8z_vT3_Bntw9N9-CxB5Bk4ij-BB6Yeh8ezr2KfB-Oli4Y9e0xOd_6VrXH5Igst2Gqb5_C3bzBf4xtyKo15KImfQqRix9Gk1Pv5G0LcPbEYVPisOkJmRA8sDqB892QPrIJaSryQW0UmV43X8mQBeSXnt39oO3UWkQ8g9X07Px0FvqMDGHJRbZBWlKEOxXN8rTQCE4Uw_NGbP2FqkSUKhMG4WTBVSmoMZwbJngh8AimI80QSBbsOezWTW1eAilTnZRZZqKiwprcKBFlhdKpNgwhCFUBRD0d5JULvCF7i7RLOZBOWtLJiOKTBiB6esnerxQloWn9smwllS1W7izacssONO4C1GQBnAwtPfJwiELixvL_YQ973pDbkQZ2DYAMxbh0rT5G1aa5aWWOwjO33sABvHAsNXxpbJGUoMmrf_d9AI_sRJxN3CHsbq5vzGsESZtiDDtvf1J8i7UYw2jy8fNsMfar4x6NJRQO |
link.rule.ids | 315,786,790,4521,12083,21416,24144,27955,27956,31752,31753,33777,33778,43343,43838,45618,45712,74100,74657 |
linkProvider | ProQuest |
linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwhV1Lb9QwEB5BkYALgvIKFJgD6qmR4tiJk15QVVgt0K162JX2ZtmxI7USSWm2SOXIL2ccJ1mQeEi5OX4kMx5_M54HwFtNKFdmZR1rkdlYZCaJDbNFLHldlYzbUvcGt8VpPl-JT-tsPRjcusGtcpSJvaC2beVt5LS7OWeEvfPs3eXX2FeN8rerQwmN23BHcC48n8v1pHAlvOwr7ngtIE5LVvzm3-UjD_sYJ-_flfa5O33R8z-fTn9Dn_0pNHsIDwb4iEeB3o_glmt24e5iuCDfhf2zkIr65gCX28iq7gD38WybpPrmMfxYtPSHqQ-uOofnDY4FRM6_O4vHQ4i3b6DVY0CmGJDpIR4hqatB3HxzOOY1wbbG93qjcXbVfsGpBsgvIwfroB_U-0M8gdXsw_J4Hg_1GOJKyGJDlGQEdmpWlLmxBE00J20j9dFCdSYrXUhHYNIIXUnmnBCOS2EkKWA2sZxgpOFPYadpG_ccsMptVhWFS0xNbwqnZVIYbXPrOAEQpiNIRjqoy5B2Q43-aBdqIp3ypFMJoyePQI70UmNUKclB1w2bslNMdfRy789WenZgaZ-epojgcOo54I6AJxQdK_-fdm_kDbWdaWLWCHBqpo3rb2N049rrTpUkOksfCxzBs8BS05emHkdJlr3499hv4N58uThRJx9PP7-E-35RwTtuD3Y2V9fuFcGljXnd74mffmUSIg |
linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwhV1Lb9QwEB5BkSouFZRXSoE5oJ4aEcdJHPeCqpZVeWy1h660N8uJHalIJKXZIpUjv5xx7GRB4iHllsR2Mp7xN_Y3MwCvNaFckcsm1llu4iyvkrhipowFb2rJuJF62HCbnxdny-zDKl8F_lMfaJWjTRwMtelqt0dO2s05I-xd5G-aQItYnM7eXn2NXQUpd9IaymnchXu0SiaujINYTc5XwuVQfcd5BHEqWfkb18tFIQ7xTo7rlQ55PF0B9D-vVH9DosOKNHsAOwFK4rGX_UO4Y9td2J6Hw_JdOFj4tNS3h3ixibLqD_EAF5uE1beP4Me8o79N7-Cyt3jZ4lhM5PK7NXgSwr3dDRo9epSKHqUe4TGS6-pNzzeLY44T7Bo81WuNs-vuC071QH5p2e8UukYdN-IxLGfvLk7O4lCbIa4zUa5JqoyAT8NKWVSGYIrm5HmkLnKoyUWtS2EJWFaZrgWzNsssF1klyBkzieEEKSv-BLbarrXPAOvC5HVZ2qRq6MnMapGUlTaFsZzACNMRJKMc1JVPwaFGbtpnNYlOOdGphNFVRCBGeakxwpRsou2DgvaKqZ4eHrht0k0Hlg6pasoIjqY3Awbx2ELREvP_bvfHuaE2PU0TNwKcbpMSu5MZ3drupleSzKh0ccERPPVTavrS1GEqwfK9f7f9CrZJHdSn9-cfn8N9NyZPlNuHrfX1jX1ByGldvRxU4idSIBZO |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Morphine+use+in+hospitalized+children+in+the+United+States%3A+a+descriptive+analysis+of+data+from+pediatric+hospitalizations+in+2008&rft.jtitle=Clinical+therapeutics&rft.au=Lasky%2C+Tamar&rft.au=Greenspan%2C+Jay&rft.au=Ernst%2C+Frank+R&rft.au=Gonzalez%2C+Liliana&rft.date=2012-03-01&rft.eissn=1879-114X&rft.volume=34&rft.issue=3&rft.spage=720&rft_id=info:doi/10.1016%2Fj.clinthera.2012.01.016&rft_id=info%3Apmid%2F22381715&rft.externalDocID=22381715 |
thumbnail_m | http://utb.summon.serialssolutions.com/2.0.0/image/custom?url=https%3A%2F%2Fcdn.clinicalkey.com%2Fck-thumbnails%2F01492918%2FS0149291811X00188%2Fcov150h.gif |