Dental Pulp-Derived Mesenchymal Stem Cells for Modeling Genetic Disorders

• Published in: International journal of molecular sciences Vol. 22; no. 5; p. 2269
• Main Authors: Masuda, Keiji, Han, Xu, Kato, Hiroki, Sato, Hiroshi, Zhang, Yu, Sun, Xiao, Hirofuji, Yuta, Yamaza, Haruyoshi, Yamada, Aya, Fukumoto, Satoshi
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 25.02.2021; MDPI
• Subjects: Apoptosis; Cell Differentiation; Congenital diseases; Dental pulp; Dental Pulp - cytology; Disease; Genetic Diseases, Inborn - pathology; Genetic disorders; Humans; Medical research; Mesenchymal Stem Cells - cytology; Models, Biological; Neurons; Physiology; Review; Stem cells; Teeth; Tissue engineering; stem cells from human exfoliated deciduous teeth; mesenchymal stem cells; dental pulp stem cells; disease model

A subpopulation of mesenchymal stem cells, developmentally derived from multipotent neural crest cells that form multiple facial tissues, resides within the dental pulp of human teeth. These stem cells show high proliferative capacity in vitro and are multipotent, including adipogenic, myogenic, ost...