Dental Pulp-Derived Mesenchymal Stem Cells for Modeling Genetic Disorders

A subpopulation of mesenchymal stem cells, developmentally derived from multipotent neural crest cells that form multiple facial tissues, resides within the dental pulp of human teeth. These stem cells show high proliferative capacity in vitro and are multipotent, including adipogenic, myogenic, ost...

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Published inInternational journal of molecular sciences Vol. 22; no. 5; p. 2269
Main Authors Masuda, Keiji, Han, Xu, Kato, Hiroki, Sato, Hiroshi, Zhang, Yu, Sun, Xiao, Hirofuji, Yuta, Yamaza, Haruyoshi, Yamada, Aya, Fukumoto, Satoshi
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 25.02.2021
MDPI
Subjects
Apoptosis
Cell Differentiation
Congenital diseases
Dental pulp
Dental Pulp - cytology
Disease
Genetic Diseases, Inborn - pathology
Genetic disorders
Humans
Medical research
Mesenchymal Stem Cells - cytology
Models, Biological
Neurons
Physiology
Review
Stem cells
Teeth
Tissue engineering
stem cells from human exfoliated deciduous teeth
mesenchymal stem cells
dental pulp stem cells
disease model
Online AccessGet full text
ISSN1422-0067
1661-6596
1422-0067
DOI10.3390/ijms22052269

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Abstract A subpopulation of mesenchymal stem cells, developmentally derived from multipotent neural crest cells that form multiple facial tissues, resides within the dental pulp of human teeth. These stem cells show high proliferative capacity in vitro and are multipotent, including adipogenic, myogenic, osteogenic, chondrogenic, and neurogenic potential. Teeth containing viable cells are harvested via minimally invasive procedures, based on various clinical diagnoses, but then usually discarded as medical waste, indicating the relatively low ethical considerations to reuse these cells for medical applications. Previous studies have demonstrated that stem cells derived from healthy subjects are an excellent source for cell-based medicine, tissue regeneration, and bioengineering. Furthermore, stem cells donated by patients affected by genetic disorders can serve as in vitro models of disease-specific genetic variants, indicating additional applications of these stem cells with high plasticity. This review discusses the benefits, limitations, and perspectives of patient-derived dental pulp stem cells as alternatives that may complement other excellent, yet incomplete stem cell models, such as induced pluripotent stem cells, together with our recent data.
AbstractList A subpopulation of mesenchymal stem cells, developmentally derived from multipotent neural crest cells that form multiple facial tissues, resides within the dental pulp of human teeth. These stem cells show high proliferative capacity in vitro and are multipotent, including adipogenic, myogenic, osteogenic, chondrogenic, and neurogenic potential. Teeth containing viable cells are harvested via minimally invasive procedures, based on various clinical diagnoses, but then usually discarded as medical waste, indicating the relatively low ethical considerations to reuse these cells for medical applications. Previous studies have demonstrated that stem cells derived from healthy subjects are an excellent source for cell-based medicine, tissue regeneration, and bioengineering. Furthermore, stem cells donated by patients affected by genetic disorders can serve as in vitro models of disease-specific genetic variants, indicating additional applications of these stem cells with high plasticity. This review discusses the benefits, limitations, and perspectives of patient-derived dental pulp stem cells as alternatives that may complement other excellent, yet incomplete stem cell models, such as induced pluripotent stem cells, together with our recent data.
A subpopulation of mesenchymal stem cells, developmentally derived from multipotent neural crest cells that form multiple facial tissues, resides within the dental pulp of human teeth. These stem cells show high proliferative capacity in vitro and are multipotent, including adipogenic, myogenic, osteogenic, chondrogenic, and neurogenic potential. Teeth containing viable cells are harvested via minimally invasive procedures, based on various clinical diagnoses, but then usually discarded as medical waste, indicating the relatively low ethical considerations to reuse these cells for medical applications. Previous studies have demonstrated that stem cells derived from healthy subjects are an excellent source for cell-based medicine, tissue regeneration, and bioengineering. Furthermore, stem cells donated by patients affected by genetic disorders can serve as in vitro models of disease-specific genetic variants, indicating additional applications of these stem cells with high plasticity. This review discusses the benefits, limitations, and perspectives of patient-derived dental pulp stem cells as alternatives that may complement other excellent, yet incomplete stem cell models, such as induced pluripotent stem cells, together with our recent data.A subpopulation of mesenchymal stem cells, developmentally derived from multipotent neural crest cells that form multiple facial tissues, resides within the dental pulp of human teeth. These stem cells show high proliferative capacity in vitro and are multipotent, including adipogenic, myogenic, osteogenic, chondrogenic, and neurogenic potential. Teeth containing viable cells are harvested via minimally invasive procedures, based on various clinical diagnoses, but then usually discarded as medical waste, indicating the relatively low ethical considerations to reuse these cells for medical applications. Previous studies have demonstrated that stem cells derived from healthy subjects are an excellent source for cell-based medicine, tissue regeneration, and bioengineering. Furthermore, stem cells donated by patients affected by genetic disorders can serve as in vitro models of disease-specific genetic variants, indicating additional applications of these stem cells with high plasticity. This review discusses the benefits, limitations, and perspectives of patient-derived dental pulp stem cells as alternatives that may complement other excellent, yet incomplete stem cell models, such as induced pluripotent stem cells, together with our recent data.
Author Yamada, Aya
Hirofuji, Yuta
Fukumoto, Satoshi
Zhang, Yu
Masuda, Keiji
Sun, Xiao
Yamaza, Haruyoshi
Kato, Hiroki
Sato, Hiroshi
Han, Xu
AuthorAffiliation 2 Department of Molecular Cell Biology and Oral Anatomy, Graduate School of Dental Science, Kyushu University, Maidashi 3-1-1, Higashi-Ku, Fukuoka 812-8582, Japan; kato@dent.kyushu-u.ac.jp
3 Division of Pediatric Dentistry, Department of Oral Health and Development Sciences, Graduate School of Dentistry, Tohoku University, 4-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi 980-8577, Japan; yamada-a@dent.tohoku.ac.jp
1 Section of Oral Medicine for Children, Division of Oral Health, Growth and Development, Faculty of Dental Science, Kyushu University, Maidashi 3-1-1, Higashi-Ku, Fukuoka 812-8582, Japan; kan@dent.kyushu-u.ac.jp (X.H.); hisato@dent.kyushu-u.ac.jp (H.S.); zhangyu@dent.kyushu-u.ac.jp (Y.Z.); sunxiao1988@dent.kyushu-u.ac.jp (X.S.); hirofuji@dent.kyushu-u.ac.jp (Y.H.); hyamaza@dent.kyushu-u.ac.jp (H.Y.)
AuthorAffiliation_xml – name: 1 Section of Oral Medicine for Children, Division of Oral Health, Growth and Development, Faculty of Dental Science, Kyushu University, Maidashi 3-1-1, Higashi-Ku, Fukuoka 812-8582, Japan; kan@dent.kyushu-u.ac.jp (X.H.); hisato@dent.kyushu-u.ac.jp (H.S.); zhangyu@dent.kyushu-u.ac.jp (Y.Z.); sunxiao1988@dent.kyushu-u.ac.jp (X.S.); hirofuji@dent.kyushu-u.ac.jp (Y.H.); hyamaza@dent.kyushu-u.ac.jp (H.Y.)
– name: 2 Department of Molecular Cell Biology and Oral Anatomy, Graduate School of Dental Science, Kyushu University, Maidashi 3-1-1, Higashi-Ku, Fukuoka 812-8582, Japan; kato@dent.kyushu-u.ac.jp
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Keywords stem cells from human exfoliated deciduous teeth
mesenchymal stem cells
dental pulp stem cells
disease model
Language English
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Snippet A subpopulation of mesenchymal stem cells, developmentally derived from multipotent neural crest cells that form multiple facial tissues, resides within the...
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StartPage 2269
SubjectTerms Apoptosis
Cell Differentiation
Congenital diseases
Dental pulp
Dental Pulp - cytology
Disease
Genetic Diseases, Inborn - pathology
Genetic disorders
Humans
Medical research
Mesenchymal Stem Cells - cytology
Models, Biological
Neurons
Physiology
Review
Stem cells
Teeth
Tissue engineering
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Title Dental Pulp-Derived Mesenchymal Stem Cells for Modeling Genetic Disorders
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Volume 22
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