Activated Ras requires autophagy to maintain oxidative metabolism and tumorigenesis

• Published in: Genes & development Vol. 25; no. 5; pp. 460 - 470
• Main Authors: Guo, Jessie Yanxiang, Chen, Hsin-Yi, Mathew, Robin, Fan, Jing, Strohecker, Anne M., Karsli-Uzunbas, Gizem, Kamphorst, Jurre J., Chen, Guanghua, Lemons, Johanna M.S., Karantza, Vassiliki, Coller, Hilary A., DiPaola, Robert S., Gelinas, Celine, Rabinowitz, Joshua D., White, Eileen
• Format: Journal Article
• Language: English
• Published: United States Cold Spring Harbor Laboratory Press 01.03.2011
• Subjects: Animals; Autophagy - physiology; Cell Line; Cell Line, Tumor; Cell Proliferation; Cell Survival - genetics; Energy Metabolism; Gene Expression Regulation, Neoplastic; Genes, ras - genetics; HCT116 Cells; Humans; Mice; Mitochondria - metabolism; Oxidation-Reduction; Research Paper; Starvation

Autophagy is a catabolic pathway used by cells to support metabolism in response to starvation and to clear damaged proteins and organelles in response to stress. We report here that expression of a H-ras V12 or K-ras V12 oncogene up-regulates basal autophagy, which is required for tumor cell surviv...