Multiple Modes of Vitamin K Actions in Aging-Related Musculoskeletal Disorders

• Published in: International journal of molecular sciences Vol. 20; no. 11; p. 2844
• Main Authors: Azuma, Kotaro, Inoue, Satoshi
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 11.06.2019; MDPI
• Subjects: Aging; Aging - metabolism; Androgens; Animal research; Animals; Arthritis; Calcification; Calcium-Binding Proteins - metabolism; Enzymes; Extracellular Matrix Proteins - metabolism; Humans; Intercellular Signaling Peptides and Proteins; Intracellular Signaling Peptides and Proteins; Kinases; Ligands; Matrix Gla Protein; Metabolism; Musculoskeletal Diseases - metabolism; Older people; Osteoporosis; Osteoporosis - metabolism; Peptides; Pregnane X Receptor - metabolism; Proteins; Proteins - metabolism; Review; Sarcopenia; Signal transduction; Vitamin K - metabolism; Working groups; Japan; γ-glutamyl carboxylase (GGCX); osteoarthritis; matrix Gla protein (MGP); osteocalcin; steroid and xenobiotic receptor (SXR); osteoporosis; pregnane X receptor (PXR); Gla-rich protein (GRP); sarcopenia

Vitamin K is a fat-soluble vitamin that was originally found as an essential factor for blood coagulation. With the discovery of its role as a co-factor for γ-glutamyl carboxylase (GGCX), its function for blood coagulation was understood as the activation of several blood coagulation factors by thei...