Overcoming Shellfish Allergy: How Far Have We Come?

Shellfish allergy caused by undesirable immunological responses upon ingestion of crustaceans and mollusks is a common cause of food allergy, especially in the Asia-Pacific region. While the prevalence of shellfish allergy is increasing, the mainstay of clinical diagnosis for these patients includes...

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Published inInternational journal of molecular sciences Vol. 21; no. 6; p. 2234
Main Authors Wai, Christine Y.Y., Leung, Nicki Y.H., Chu, Ka Hou, Leung, Patrick S.C., Leung, Agnes S.Y., Wong, Gary W.K., Leung, Ting Fan
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 23.03.2020
MDPI
Subjects
Adults
Allergens - immunology
Anaphylaxis
Animals
Cockroaches
Combined Modality Therapy
Cross Reactions - immunology
Crustaceans
Desensitization, Immunologic
Disease Management
Disease Susceptibility
Epidemiology
Food allergies
Humans
Immunoglobulin E - immunology
Molecular weight
Mollusks
Population
Prevalence
Proteins
Quality of life
Review
Seafood - adverse effects
Shellfish
Shellfish - adverse effects
Shellfish Hypersensitivity - diagnosis
Shellfish Hypersensitivity - immunology
Shellfish Hypersensitivity - prevention & control
Shellfish Hypersensitivity - therapy
Vaccines - immunology
Hong Kong China
Singapore
Thailand
Asia
United States > US
China
DNA vaccine
diagnosis
tropomyosin
component-resolved diagnosis
allergen-specific immunotherapy
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Abstract Shellfish allergy caused by undesirable immunological responses upon ingestion of crustaceans and mollusks is a common cause of food allergy, especially in the Asia-Pacific region. While the prevalence of shellfish allergy is increasing, the mainstay of clinical diagnosis for these patients includes extract-based skin prick test and specific IgE measurement while clinical management consists of food avoidance and as-needed use of adrenaline autoinjector should they develop severe allergic reactions. Such a standard of care is unsatisfactory to both patients and healthcare practitioners. There is a pressing need to introduce more specific diagnostic methods, as well as effective and safe therapies for patients with shellfish allergy. Knowledge gained on the identifications and defining the immuno-molecular features of different shellfish allergens over the past two decades have gradually translated into the design of new diagnostic and treatment options for shellfish allergy. In this review, we will discuss the epidemiology, the molecular identification of shellfish allergens, recent progress in various diagnostic methods, as well as current development in immunotherapeutic approaches including the use of unmodified allergens, hypoallergens, immunoregulatory peptides and DNA vaccines for the prevention and treatment of shellfish allergy. The prospect of a “cure “for shellfish allergy is within reach.
AbstractList Shellfish allergy caused by undesirable immunological responses upon ingestion of crustaceans and mollusks is a common cause of food allergy, especially in the Asia-Pacific region. While the prevalence of shellfish allergy is increasing, the mainstay of clinical diagnosis for these patients includes extract-based skin prick test and specific IgE measurement while clinical management consists of food avoidance and as-needed use of adrenaline autoinjector should they develop severe allergic reactions. Such a standard of care is unsatisfactory to both patients and healthcare practitioners. There is a pressing need to introduce more specific diagnostic methods, as well as effective and safe therapies for patients with shellfish allergy. Knowledge gained on the identifications and defining the immuno-molecular features of different shellfish allergens over the past two decades have gradually translated into the design of new diagnostic and treatment options for shellfish allergy. In this review, we will discuss the epidemiology, the molecular identification of shellfish allergens, recent progress in various diagnostic methods, as well as current development in immunotherapeutic approaches including the use of unmodified allergens, hypoallergens, immunoregulatory peptides and DNA vaccines for the prevention and treatment of shellfish allergy. The prospect of a "cure "for shellfish allergy is within reach.
Shellfish allergy caused by undesirable immunological responses upon ingestion of crustaceans and mollusks is a common cause of food allergy, especially in the Asia-Pacific region. While the prevalence of shellfish allergy is increasing, the mainstay of clinical diagnosis for these patients includes extract-based skin prick test and specific IgE measurement while clinical management consists of food avoidance and as-needed use of adrenaline autoinjector should they develop severe allergic reactions. Such a standard of care is unsatisfactory to both patients and healthcare practitioners. There is a pressing need to introduce more specific diagnostic methods, as well as effective and safe therapies for patients with shellfish allergy. Knowledge gained on the identifications and defining the immuno-molecular features of different shellfish allergens over the past two decades have gradually translated into the design of new diagnostic and treatment options for shellfish allergy. In this review, we will discuss the epidemiology, the molecular identification of shellfish allergens, recent progress in various diagnostic methods, as well as current development in immunotherapeutic approaches including the use of unmodified allergens, hypoallergens, immunoregulatory peptides and DNA vaccines for the prevention and treatment of shellfish allergy. The prospect of a "cure "for shellfish allergy is within reach.Shellfish allergy caused by undesirable immunological responses upon ingestion of crustaceans and mollusks is a common cause of food allergy, especially in the Asia-Pacific region. While the prevalence of shellfish allergy is increasing, the mainstay of clinical diagnosis for these patients includes extract-based skin prick test and specific IgE measurement while clinical management consists of food avoidance and as-needed use of adrenaline autoinjector should they develop severe allergic reactions. Such a standard of care is unsatisfactory to both patients and healthcare practitioners. There is a pressing need to introduce more specific diagnostic methods, as well as effective and safe therapies for patients with shellfish allergy. Knowledge gained on the identifications and defining the immuno-molecular features of different shellfish allergens over the past two decades have gradually translated into the design of new diagnostic and treatment options for shellfish allergy. In this review, we will discuss the epidemiology, the molecular identification of shellfish allergens, recent progress in various diagnostic methods, as well as current development in immunotherapeutic approaches including the use of unmodified allergens, hypoallergens, immunoregulatory peptides and DNA vaccines for the prevention and treatment of shellfish allergy. The prospect of a "cure "for shellfish allergy is within reach.
Author Leung, Nicki Y.H.
Leung, Agnes S.Y.
Wong, Gary W.K.
Leung, Patrick S.C.
Leung, Ting Fan
Chu, Ka Hou
Wai, Christine Y.Y.
AuthorAffiliation 2 Hong Kong Hub of Paediatric Excellence, The Chinese University of Hong Kong, Shatin, Hong Kong
3 School of Life Sciences, The Chinese University of Hong Kong, Shatin, Hong Kong; kahouchu@cuhk.edu.hk
1 Department of Paediatrics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
4 Division of Rheumatology/Allergy, School of Medicine, University of California, Davis, CA 95616, USA; psleung@ucdavis.edu
AuthorAffiliation_xml – name: 1 Department of Paediatrics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
– name: 2 Hong Kong Hub of Paediatric Excellence, The Chinese University of Hong Kong, Shatin, Hong Kong
– name: 3 School of Life Sciences, The Chinese University of Hong Kong, Shatin, Hong Kong; kahouchu@cuhk.edu.hk
– name: 4 Division of Rheumatology/Allergy, School of Medicine, University of California, Davis, CA 95616, USA; psleung@ucdavis.edu
Author_xml – sequence: 1
  givenname: Christine Y.Y.
  surname: Wai
  fullname: Wai, Christine Y.Y.
– sequence: 2
  givenname: Nicki Y.H.
  surname: Leung
  fullname: Leung, Nicki Y.H.
– sequence: 3
  givenname: Ka Hou
  orcidid: 0000-0001-8107-5415
  surname: Chu
  fullname: Chu, Ka Hou
– sequence: 4
  givenname: Patrick S.C.
  surname: Leung
  fullname: Leung, Patrick S.C.
– sequence: 5
  givenname: Agnes S.Y.
  orcidid: 0000-0001-8249-4478
  surname: Leung
  fullname: Leung, Agnes S.Y.
– sequence: 6
  givenname: Gary W.K.
  surname: Wong
  fullname: Wong, Gary W.K.
– sequence: 7
  givenname: Ting Fan
  orcidid: 0000-0002-6469-1926
  surname: Leung
  fullname: Leung, Ting Fan
BackLink https://www.ncbi.nlm.nih.gov/pubmed/32210187$$D View this record in MEDLINE/PubMed
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Keywords DNA vaccine
diagnosis
tropomyosin
component-resolved diagnosis
allergen-specific immunotherapy
Language English
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Short title: Management of shellfish allergy.
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Snippet Shellfish allergy caused by undesirable immunological responses upon ingestion of crustaceans and mollusks is a common cause of food allergy, especially in the...
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StartPage 2234
SubjectTerms Adults
Allergens - immunology
Anaphylaxis
Animals
Cockroaches
Combined Modality Therapy
Cross Reactions - immunology
Crustaceans
Desensitization, Immunologic
Disease Management
Disease Susceptibility
Epidemiology
Food allergies
Humans
Immunoglobulin E - immunology
Molecular weight
Mollusks
Population
Prevalence
Proteins
Quality of life
Review
Seafood - adverse effects
Shellfish
Shellfish - adverse effects
Shellfish Hypersensitivity - diagnosis
Shellfish Hypersensitivity - immunology
Shellfish Hypersensitivity - prevention & control
Shellfish Hypersensitivity - therapy
Vaccines - immunology
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Title Overcoming Shellfish Allergy: How Far Have We Come?
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