Endotoxin Exposure Is a Risk Factor for Asthma: The National Survey of Endotoxin in United States Housing

• Published in: American journal of respiratory and critical care medicine Vol. 172; no. 11; pp. 1371 - 1377
• Main Authors: Thorne, Peter S, Kulhankova, Katarina, Yin, Ming, Cohn, Richard, Arbes, Samuel J., Jr, Zeldin, Darryl C
• Format: Journal Article
• Language: English
• Published: New York, NY Am Thoracic Soc 01.12.2005; American Lung Association; American Thoracic Society
• Subjects: A. Asthma and Allergy; Adult; Air Pollutants - adverse effects; Air Pollutants - chemistry; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy; Asthma - chemically induced; Asthma - epidemiology; Biological and medical sciences; Blood and lymphatic vessels; Blood. Blood and plasma substitutes. Blood products. Blood cells. Blood typing. Plasmapheresis. Apheresis; Cardiology. Vascular system; Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous; Dust - analysis; Endotoxins - adverse effects; Endotoxins - analysis; Health Surveys; Housing; Humans; Intensive care medicine; Medical sciences; Odds Ratio; Prevalence; Risk Factors; Surveys and Questionnaires; Transfusions. Complications. Transfusion reactions. Cell and gene therapy; United States - epidemiology; United States; North America; America; airway inflammation; Lung disease; Intensive care; Respiratory disease; wheeze; Wheezing; Inflammation; Endotoxin; Asthma; Toxin; house dust; Risk factor; Lipopolysaccharide; Bronchus disease; Obstructive pulmonary disease; Resuscitation

Although research has shown that early life exposure to household endotoxin protects against development of allergies, studies are less clear on the relationship between household endotoxin exposure and prevalence of wheezing and asthma. We assayed 2,552 house dust samples in a representative nation...