The emerging epitranscriptomics of long noncoding RNAs

• Published in: Biochimica et biophysica acta Vol. 1859; no. 1; pp. 59 - 70
• Main Authors: Shafik, Andrew, Schumann, Ulrike, Evers, Maurits, Sibbritt, Tennille, Preiss, Thomas
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.01.2016
• Subjects: 5-Methylcytidine; Adenosine - genetics; Animals; Cytidine - analogs & derivatives; Cytidine - chemistry; Editing; Epigenomics; Genome; Humans; lncRNA; miRNAs; N6-methyladenosine; Pseudouridine; RNA, Long Noncoding - chemistry; RNA, Long Noncoding - genetics; RNA, Transfer - chemistry; RNA, Transfer - genetics; Transcription, Genetic; Transcriptome - genetics; Aza-IP; hm5C; lncRNA; miRNAs; Ψ; Editing; 5-Methylcytidine; Pseudouridine; miCLIP; m6A; m5C; bsRNA-seq; N6-methyladenosine; NGS; iCLIP

The pervasive transcription of genomes into long noncoding RNAs has been amply demonstrated in recent years and garnered much attention. Similarly, emerging ‘epitranscriptomics’ research has shown that chemically modified nucleosides, thought to be largely the domain of tRNAs and other infrastructur...