Extracellular matrix abnormalities in schizophrenia

• Published in: Neuropharmacology Vol. 62; no. 3; pp. 1584 - 1597
• Main Author: Berretta, Sabina
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.03.2012
• Subjects: Animals; Astrocytes; Chondroitin sulfate proteoglycans; Extracellular matrix; Extracellular Matrix - metabolism; Extracellular Matrix - pathology; Extracellular Matrix Proteins - metabolism; Humans; Perineuronal nets; Reelin; Reelin Protein; Schizophrenia; Schizophrenia - metabolism; Schizophrenia - pathology; Signal Transduction; Astrocytes; EGF; SZ; Schizophrenia; GAD67; ECM; Chondroitin sulfate proteoglycans; GFAP; PNN; TGF-beta; Reelin; WFA; Extracellular matrix; Perineuronal nets; CSPGs; ECx; PVB
• ISSN: 0028-3908; 1873-7064; 1873-7064
• DOI: 10.1016/j.neuropharm.2011.08.010

Emerging evidence points to the involvement of the brain extracellular matrix (ECM) in the pathophysiology of schizophrenia (SZ). Abnormalities affecting several ECM components, including Reelin and chondroitin sulfate proteoglycans (CSPGs), have been described in subjects with this disease. Solid e...